SCHEMBL7806641

SCHEMBL7806641

CN(C)c1ccccc1.CN(C)c1ccccc1.O=S(=O)([O-])S(=O)(=O)[O-].[Na+].[Na+]

nearest known ligand 0.57

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 known ✓ O43570 4/20 0.57
CA2 known ✓ P00918 3/20 0.57
CA1 known ✓ P00915 2/20 0.43
CA4 known ✓ P22748 2/20 0.43
CA9 Q16790 4/20 0.57
ALDH1A1 P00352 5/20 0.48
ALOX15 P16050 3/20 0.48
TSHR P16473 3/20 0.48
RAB9A P51151 2/20 0.45
HPGD P15428 2/20 0.45
NPC1 O15118 1/20 0.45
KEAP1 Q14145 1/20 0.44
NFE2L2 Q16236 1/20 0.44
HSD17B10 Q99714 3/20 0.44
KDM4E B2RXH2 1/20 0.44
MAPK1 P28482 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
RELA Q04206 1/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1244154 0.84 CA12 (0.50) CA12CA9CA2ALDH1A1ALOX15
SCHEMBL30882073 0.83 ALDH1A1 (0.56) CA12CA9CA2ALDH1A1ALOX15
Sulfuric Acid SCHEMBL4958447 0.81 HPGD (0.54) CA12CA9CA2ALDH1A1ALOX15
SCHEMBL27273951 0.81 RAB9A (0.48) CA12CA9CA2ALDH1A1ALOX15
Water SCHEMBL10540128 0.80 ALDH1A1 (0.59) CA12CA9CA2ALDH1A1ALOX15
SCHEMBL16187039 0.80
SCHEMBL21208167 0.80 ALDH1A1 (0.67) CA12CA9CA2ALDH1A1ALOX15
SCHEMBL7879117 0.80
SCHEMBL8277 0.80
SCHEMBL10557768 0.80 ALDH1A1 (0.67) CA12CA9CA2ALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0576201-B1 Fungicidal 1,2,4-triazoles ROHM & HAAS (US) 2001-08-16 EP disclosed
US-5624916-A Fungicidal 1,2,4-triazoles ROHM AND HAAS COMPANY (US) 1997-04-29 US disclosed
US-5462931-A Controlling phytopathogens ROHM AND HAAS COMPANY (US) 1995-10-31 US disclosed
US-5358939-A For applying to soils, seeds, plants, or for storage of cereal grains ROHM AND HAAS COMPANY (US) 1994-10-25 US disclosed
EP-0576201-A2 Fungicidal 1,2,4-triazoles ROHM AND HAAS COMPANY (US) 1993-12-29 EP disclosed