SCHEMBL1248258

SCHEMBL1248258

CC1CCC(C(C)C)C(OC(=O)CC([NH])=O)C1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.56
EPHX1 P07099 3/20 0.56
ALDH1A1 P00352 8/20 0.50
TSHR P16473 2/20 0.49
MAPT P10636 2/20 0.49
LMNA P02545 2/20 0.49
NPSR1 Q6W5P4 2/20 0.49
USP2 O75604 1/20 0.49
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
HPGD P15428 2/20 0.48
MAPK1 P28482 2/20 0.47
KDM4E B2RXH2 1/20 0.47
GAA P10253 1/20 0.47
NPC1 O15118 1/20 0.44
MITF O75030 1/20 0.44
TP53 P04637 1/20 0.44
HTT P42858 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5010580 0.91 CYP19A1 (0.61) CYP19A1EPHX1ALDH1A1TSHRMAPT
SCHEMBL5010581 0.87 CYP19A1 (0.57) CYP19A1EPHX1ALDH1A1TSHRMAPT
SCHEMBL12994248 0.87 CYP19A1 (0.57) CYP19A1EPHX1ALDH1A1TSHRMAPT
SCHEMBL18832114 0.87 CYP19A1 (0.57) CYP19A1EPHX1ALDH1A1TSHRMAPT
SCHEMBL10064065 0.87 CYP19A1 (0.57) CYP19A1EPHX1ALDH1A1TSHRMAPT
SCHEMBL15914460 0.87 CYP19A1 (0.57) CYP19A1EPHX1ALDH1A1TSHRMAPT
SCHEMBL119559 0.87 CYP19A1 (0.57) CYP19A1EPHX1ALDH1A1TSHRMAPT
SCHEMBL13953844 0.85 CYP19A1 (0.56) CYP19A1EPHX1ALDH1A1TSHRMAPT
SCHEMBL23255563 0.84 CYP19A1 (0.61) CYP19A1EPHX1ALDH1A1TSHRMAPT
SCHEMBL7991612 0.84 CYP19A1 (0.61) CYP19A1EPHX1ALDH1A1TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10584134-B2 Use of physiological cooling active ingredients, and agents containing such active ingredients SYMRISE AG (DE) 2020-03-10 US claimed
EP-3142499-B1 HOMOVANILLIC ACID ESTERS, IN PARTICULAR FOR ACHIEVING AN IMPRESSION OF HEAT AND/OR SPICINESS SYMRISE AG (DE) 2019-10-30 EP claimed
US-10392371-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2019-08-27 US claimed
US-20180093997-A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS SYMRISE AG (DE) 2018-04-05 US claimed
US-9718839-B2 Use of physiological cooling active ingredients, and agents containing such active ingredients SYMRISE AG (DE) 2017-08-01 US claimed
US-20150086491-A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS SYMRISE AG (DE) 2015-03-26 US claimed
US-8927605-B2 Use of physiological cooling active ingredients, and agents containing such active ingredients SYMRISE AG (DE) 2015-01-06 US claimed
US-20120263659-A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS BASF SE (DE) 2012-10-18 US claimed
EP-4192614-B1 PROCESS FOR THE PREPARATION OF MICROCAPSULES SYMRISE AG (DE) 2026-05-06 EP disclosed
US-20250387310-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT FIRMENICH INCORPORATED (US) 2025-12-25 US disclosed
EP-4525821-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT Firmenich Incorporated (US) 2025-03-26 EP disclosed
US-20240293790-A1 Biodegradable Polyurea/Polyurethane Microcapsules SYMRISE AG (DE) 2024-09-05 US disclosed
US-20240238183-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT FIRMENICH INCORPORATED (US) 2024-07-18 US disclosed
US-20240033703-A1 Method for Producing Microcapsules AG, SYMRISE (DE) 2024-02-01 US disclosed
US-20120263659-A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS BASF SE (DE) 2012-10-18 US disclosed
US-20110305657-A1 Cooling Mixtures with an enhanced cooling effect of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate SYMRISE AG (DE) 2011-12-15 US disclosed
EP-2389922-A1 Cyclohexyl carbamate compounds as anti-ageing actives Symrise AG (DE) 2011-11-30 EP disclosed
US-20110081303-A1 TEETH CLEANING COMPOUND CONTAINING MENTHOL WITH REDUCED BITTER SENSATION SYMRISE AG (DE) 2011-04-07 US disclosed
US-20110034486-A1 USE OF PTEROCARPANS AS ACTIVE ANTI-CELLULITE INGREDIENTS SYMRISE GMBH & CO., KG (DE) 2011-02-10 US disclosed
WO-2010149798-A2 USE OF POLYOLS FOR ENHANCING THE COOLING EFFECT OF A COOLING SUBSTANCE AND COOLING MIXTURES HAVING AN ENHANCED COOLING EFFECT SYMRISE AG (DE) 2010-12-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110305657-A1 Cooling Mixtures with an enhanced cooling effect of 5-methyl-2-(propane-2-yl)cyclohexyl-N-ethyloxamate NT5C, SUCLG1, CUTA CYP19A1 1286/4885EPHX1 1512/4885ALDH1A1 2344/4885
US-10392371-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM4, TRPM6 CYP19A1 4071/4885EPHX1 4010/4885ALDH1A1 3726/4885
US-20110081303-A1 TEETH CLEANING COMPOUND CONTAINING MENTHOL WITH REDUCED BITTER SENSATION TAS2R10, TAS2R30, TAS2R14 CYP19A1 4858/4885EPHX1 294/4885ALDH1A1 3012/4885
US-20110034486-A1 USE OF PTEROCARPANS AS ACTIVE ANTI-CELLULITE INGREDIENTS FABP4, PLIN1, CPT1B CYP19A1 64/4885EPHX1 2934/4885ALDH1A1 2907/4885
US-20250387310-A1 COMPOSITIONS THAT ENHANCE THE COOLING EFFECT TAS2R30, TAS2R1, TAS2R20 CYP19A1 3458/4885EPHX1 2205/4885ALDH1A1 540/4885
US-20150086491-A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS TRPM8, TRPM7, TRPM2 CYP19A1 2794/4885EPHX1 2725/4885ALDH1A1 2466/4885
US-10584134-B2 Use of physiological cooling active ingredients, and agents containing such active ingredients TRPM8, TRPM7, TRPM2 CYP19A1 2794/4885EPHX1 2725/4885ALDH1A1 2466/4885
US-20180093997-A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS TRPM8, TRPM7, TRPM2 CYP19A1 2794/4885EPHX1 2725/4885ALDH1A1 2466/4885
US-20120263659-A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS TRPM8, TRPM7, TRPM2 CYP19A1 2794/4885EPHX1 2725/4885ALDH1A1 2466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.