Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Rebamipide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.54 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.47 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.46 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.46 |
| ▸ | UBASH3B | Q8TF42 | 1/20 | 0.96 |
| ▸ | ITGB2 | P05107 | 6/20 | 0.53 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.53 |
| ▸ | ITGAL | P20701 | 6/20 | 0.53 |
| ▸ | F11 | P03951 | 2/20 | 0.53 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rebamipide SCHEMBL23346201 | 0.98 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL5794018 | 0.98 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL21623658 | 0.98 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL29560992 | 0.98 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL221527 | 0.98 | UBASH3B (1.00) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL2292009 | 0.97 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL9114879 | 0.97 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL27858766 | 0.97 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL28798513 | 0.97 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL | |
| Rebamipide SCHEMBL26607915 | 0.97 | UBASH3B (0.98) | UBASH3BPPARGITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688552-A1 | A PHARMACEUTICAL COMPOSITION FOR TREATING A DISEASE IN THE ORAL CAVITY COMPRISING REBAMIPIDE | Otsuka Pharmaceutical Co., Ltd. (JP) | 2014-01-29 | — | — | EP | disclosed |
| WO-2012128394-A1 | A PHARMACEUTICAL COMPOSITION FOR TREATING A DISEASE IN THE ORAL CAVITY COMPRISING REBAMIPIDE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-09-27 | — | — | WO | disclosed |