Sugi Predict

Sugi Predict / Compounds / SCHEMBL1270873

SCHEMBL1270873

SCHEMBL1270873

Nc1nc(=O)n(S(=O)(=O)c2ccccc2)cc1F

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ DCK P27707 8/20 0.49
▸ HTR6 P50406 7/20 0.41
▸ MEN1 O00255 2/20 0.41
▸ HTT P42858 2/20 0.41
▸ KMT2A Q03164 2/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ HPGD P15428 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ PARL Q9H300 1/20 0.40
▸ CXCL8 P10145 1/20 0.40
▸ NOD1 Q9Y239 1/20 0.40
▸ CYP2C19 P33261 1/20 0.39
▸ DRD2 P14416 2/20 0.38
▸ HTR2A P28223 1/20 0.38
▸ HTR7 P34969 1/20 0.38
▸ PKM P14618 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12932953 0.88 HTR6 (0.43) DCKHTR6LMNATSHRPKM
SCHEMBL1271033 0.85 ALDH1A1 (0.48) DCKHTR6MEN1KMT2AALDH1A1
SCHEMBL12900467 0.85 DCK (0.43) DCKALDH1A1LMNA
SCHEMBL12900477 0.85 MEN1 (0.45) DCKHTR6MEN1HTTKMT2A
SCHEMBL12900461 0.83 NOD1 (0.45) DCKHTR6ALDH1A1NOD1
SCHEMBL12900482 0.82 HTR6 (0.44) DCKHTR6MEN1HTTKMT2A
SCHEMBL12900473 0.82 DCK (0.44) DCKHTR6MEN1HTTKMT2A
Benzene SCHEMBL28349605 0.80 DCK (0.41) DCK
SCHEMBL12900475 0.79 NOD1 (0.44) DCKHTR6NOD1
SCHEMBL12900476 0.78 MET (0.40) DCKPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3862347-A1 PROCESSES FOR THEIR PREPARATION OF 5-FLUORO-4-IMINO-3-(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)- 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE ADAMA MAKHTESHIM LTD. (IL) 2021-08-11 — — EP disclosed
EP-3862346-A1 PROCESSES FOR THE PREPARATION OF 5-FLUORO-4-IMINO-3-(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)- 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE ADAMA MAKHTESHIM LTD. (IL) 2021-08-11 — — EP disclosed
EP-3862346-A1 PROCESSES FOR THE PREPARATION OF 5-FLUORO-4-IMINO-3-(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)- 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE ADAMA MAKHTESHIM LTD. (IL) 2021-08-11 — — EP disclosed
EP-3862347-A1 PROCESSES FOR THEIR PREPARATION OF 5-FLUORO-4-IMINO-3-(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)- 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE ADAMA MAKHTESHIM LTD. (IL) 2021-08-11 — — EP disclosed
EP-2953463-B1 3-ALKYL-5-FLUORO-4-SUBSTITUTED-IMINO-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AS FUNGICIDES ADAMA MAKHTESHIM LTD (IL) 2021-03-17 — — EP disclosed
US-10919864-B2 5-fluoro-4-imino-3(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1H)-one and processes for their preparation ADAMA MAKHTESHIM LTD. (IL) 2021-02-16 — — US disclosed
US-10919864-B2 5-fluoro-4-imino-3(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1H)-one and processes for their preparation ADAMA MAKHTESHIM LTD. (IL) 2021-02-16 — — US disclosed
CN-112094262-A Compounds as fungicides 阿达玛马克西姆股份有限公司 2020-12-18 — — CN disclosed
US-20200148649-A1 5-FLUORO-4-IMINO-3(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE AND PROCESSES FOR THEIR PREPARATION ADAMA MAKHTESHIM LTD. (IL) 2020-05-14 — — US disclosed
US-20200148649-A1 5-FLUORO-4-IMINO-3(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE AND PROCESSES FOR THEIR PREPARATION ADAMA MAKHTESHIM LTD. (IL) 2020-05-14 — — US disclosed
US-20130045984-A1 5-FLUORO-4-IMINO-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES DERIVATIVES DOW AGROSCIENCES LLC (US) 2013-02-21 — — US disclosed
US-8263603-B2 N3-substituted-N1-sulfonyl-5-fluoropyrimidinone derivatives DOW AGROSCIENCES, LLC (US) 2012-09-11 — — US disclosed
EP-2462134-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES Dow AgroSciences LLC (US) 2012-06-13 — — EP disclosed
WO-2011137002-A1 N3-SUBSTITUTED-N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-11-03 — — WO disclosed
US-20110263627-A1 N3-SUBSTITUTED-N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-10-27 — — US disclosed
WO-2011017547-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-02-10 — — WO disclosed
WO-2011017547-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-02-10 — — WO disclosed
US-20110034493-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-02-10 — — US disclosed
US-20110034493-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-02-10 — — US disclosed
US-20110034493-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-02-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10919864-B2 5-fluoro-4-imino-3(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1H)-one and processes for their preparation FLI1, PAICS, MCL1 DCK 18/4885HTR6 4244/4885MEN1 387/4885
US-20200148649-A1 5-FLUORO-4-IMINO-3(ALKYL/SUBSTITUTED ALKYL)-1-(ARYLSULFONYL)-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE AND PROCESSES FOR THEIR PREPARATION FLI1, PAICS, MCL1 DCK 18/4885HTR6 4244/4885MEN1 387/4885
US-20130045984-A1 5-FLUORO-4-IMINO-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES DERIVATIVES DDT, CASP3, CYP4B1 DCK 1161/4885HTR6 2839/4885MEN1 1527/4885
US-20110263627-A1 N3-SUBSTITUTED-N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DDT, FOXO3, NANP DCK 3056/4885HTR6 2224/4885MEN1 496/4885
US-20110034493-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DDT, SULT1E1, CYP1A1 DCK 3154/4885HTR6 2599/4885MEN1 741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.