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SCHEMBL12900482

SCHEMBL12900482

COc1ccc(S(=O)(=O)n2cc(F)c(N)nc2=O)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR6 P50406 2/20 0.44
▸ CXCL8 P10145 1/20 0.44
▸ NOD1 Q9Y239 1/20 0.44
▸ DCK P27707 1/20 0.44
▸ MMP2 P08253 1/20 0.43
▸ PKM P14618 3/20 0.43
▸ PKLR P30613 2/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ MAPT P10636 2/20 0.43
▸ POLB P06746 1/20 0.43
▸ RAPGEF4 Q8WZA2 1/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ KDM4E B2RXH2 1/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ LMNA P02545 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ HTT P42858 1/20 0.41
▸ TNF P01375 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12900467 0.85 DCK (0.43) DCKPOLBALDH1A1LMNA
SCHEMBL12900477 0.85 MEN1 (0.45) HTR6CXCL8NOD1DCKMMP2
SCHEMBL12932953 0.85 HTR6 (0.43) HTR6DCKMMP2PKMLMNA
SCHEMBL1271033 0.82 ALDH1A1 (0.48) HTR6CXCL8NOD1DCKMMP2
SCHEMBL1270873 0.82 DCK (0.49) HTR6CXCL8NOD1DCKPKM
SCHEMBL12900461 0.80 NOD1 (0.45) HTR6NOD1DCKALDH1A1
SCHEMBL12900473 0.79 DCK (0.44) HTR6DCKMAPTPOLBMEN1
SCHEMBL12900449 0.77 HTR6 (0.43) HTR6MMP2PKMPKLRNPC1
SCHEMBL12900475 0.76 NOD1 (0.44) HTR6NOD1DCKRAB9A
SCHEMBL12741757 0.75 ADORA3 (0.43) DCKPKMMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2953463-B1 3-ALKYL-5-FLUORO-4-SUBSTITUTED-IMINO-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AS FUNGICIDES ADAMA MAKHTESHIM LTD (IL) 2021-03-17 — — EP disclosed
CN-112094262-A Compounds as fungicides 阿达玛马克西姆股份有限公司 2020-12-18 — — CN disclosed
EP-3689142-A1 1-(SUBSTITUTED-BENZOYL)-5-FLUORO-4-IMINO-3-METHYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES Adama Makhteshim Ltd. (IL) 2020-08-05 — — EP disclosed
EP-3689142-A1 1-(SUBSTITUTED-BENZOYL)-5-FLUORO-4-IMINO-3-METHYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES Adama Makhteshim Ltd. (IL) 2020-08-05 — — EP disclosed
CN-106977462-B 5-fluoro-4-imino-3- (substituted) -3, 4-dihydropyrimidin-2 (1H) one derivatives 阿达玛马克西姆股份有限公司 2020-04-28 — — CN disclosed
US-10059703-B2 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides ADAMA MAKHTESHIM LTD. (IL) 2018-08-28 — — US disclosed
US-9908855-B2 N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxylate derivatives ADAMA MAKHTESHIM LTD. (IL) 2018-03-06 — — US disclosed
US-9908855-B2 N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxylate derivatives ADAMA MAKHTESHIM LTD. (IL) 2018-03-06 — — US disclosed
US-9908855-B2 N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxylate derivatives ADAMA MAKHTESHIM LTD. (IL) 2018-03-06 — — US disclosed
US-9862686-B2 N1-sulfonyl-5-fluoropyrimidinone derivatives ADAMA MAKHTESHIM LTD. (IL) 2018-01-09 — — US disclosed
US-8658660-B2 5-fluoro-4-imino-3,4-dihydropyrimidin-2-(1H)-ones derivatives DOW AGROSCIENCES, LLC. (US) 2014-02-25 — — US disclosed
US-8658660-B2 5-fluoro-4-imino-3,4-dihydropyrimidin-2-(1H)-ones derivatives DOW AGROSCIENCES, LLC. (US) 2014-02-25 — — US disclosed
WO-2013025795-A1 5-FLUORO-4-IMINO-3-(SUBSTITUTED)-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2013-02-21 — — WO disclosed
US-20130045984-A1 5-FLUORO-4-IMINO-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES DERIVATIVES DOW AGROSCIENCES LLC (US) 2013-02-21 — — US disclosed
US-20130045984-A1 5-FLUORO-4-IMINO-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES DERIVATIVES DOW AGROSCIENCES LLC (US) 2013-02-21 — — US disclosed
WO-2013025795-A1 5-FLUORO-4-IMINO-3-(SUBSTITUTED)-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2013-02-21 — — WO disclosed
US-20130045984-A1 5-FLUORO-4-IMINO-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES DERIVATIVES DOW AGROSCIENCES LLC (US) 2013-02-21 — — US disclosed
US-20110034493-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-02-10 — — US disclosed
WO-2011017547-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-02-10 — — WO disclosed
US-20110034493-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-02-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130045984-A1 5-FLUORO-4-IMINO-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES DERIVATIVES DDT, CASP3, CYP4B1 HTR6 2839/4885CXCL8 4440/4885NOD1 2867/4885
US-10059703-B2 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides DPM1, DERL1, DDT HTR6 4072/4885CXCL8 3828/4885NOD1 1649/4885
US-20110034493-A1 N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES DDT, SULT1E1, CYP1A1 HTR6 2599/4885CXCL8 4764/4885NOD1 1986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.