Sugi Predict

Sugi Predict / Compounds / SCHEMBL127091

SCHEMBL127091

SCHEMBL127091

Fc1cccc(CBr)c1F

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TAAR1 Q96RJ0 3/20 0.39
▸ CES2 O00748 1/20 0.38
▸ BCHE P06276 1/20 0.38
▸ CES1 P23141 1/20 0.38
▸ RIPK1 Q13546 1/20 0.38
▸ IDO1 P14902 2/20 0.37
▸ AKR1B1 P15121 1/20 0.37
▸ HTR2C P28335 1/20 0.36
▸ HTR2B P41595 1/20 0.36
▸ MPO P05164 1/20 0.35
▸ LMNA P02545 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ CXCR2 P25025 1/20 0.33
▸ MEP1B Q16820 1/20 0.33
▸ MAOB P27338 1/20 0.32
▸ GPR84 Q9NQS5 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5734027 1.00 TAAR1 (0.39) TAAR1CES2BCHECES1RIPK1
SCHEMBL960397 0.87 GABRA1 (0.36) TAAR1IDO1MEP1BALDH1A1
SCHEMBL10733339 0.84 IDO1 (0.42) IDO1HTR2CHTR2BALDH1A1
SCHEMBL29447871 0.81 TAAR1 (0.41) TAAR1CES2BCHECES1RIPK1
SCHEMBL3121976 0.81 TAAR1 (0.41) TAAR1CES2BCHECES1RIPK1
SCHEMBL20465742 0.79 — —
SCHEMBL30765100 0.79 — —
SCHEMBL489658 0.79 CES2 (0.37) CES2CES1RIPK1MEP1BGPR84
SCHEMBL5054 0.79 — —
SCHEMBL7052559 0.79 TAAR1 (0.48) TAAR1CES2BCHECES1RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1081 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119798216-A Synthesis method of Marbalol Sha Wei intermediate impurity 重庆圣华曦药业股份有限公司 2025-04-11 — — CN claimed
CN-116640106-B Phenylpiperazine compound and preparation method and application thereof 郑州大学 2024-03-08 — — CN claimed
CN-116640106-A Phenylpiperazine compound and preparation method and application thereof 郑州大学 2023-08-25 — — CN claimed
US-20080177077-A1 PROCESSES FOR THE PREPARATION OF 3-(4-(2,4-DIFLUOROBENZYLOXY)-3-BROMO-6-METHYL-2-OXOPYRIDIN-1(2H)-YL)-N,4-DIMETHYLBENZAMIDE PFIZER, INC. 2008-07-24 — — US claimed
US-12570675-B2 Boronic acid compounds LG CHEM, LTD. (KR) 2026-03-10 — — US disclosed
US-20260007672-A1 INHIBITORS OF MPTP NRG THERAPEUTICS LTD (GB) 2026-01-08 — — US disclosed
US-12491185-B2 Inhibitors of mPTP NRG THERAPEUTICS LTD (GB) 2025-12-09 — — US disclosed
EP-4652162-A1 INHIBITORS OF MPTP NRG Therapeutics LTD (GB) 2025-11-26 — — EP disclosed
US-20250340557-A1 PYRIMIDINE DERIVATIVE ASKA PHARMACEUTICAL CO., LTD. (JP) 2025-11-06 — — US disclosed
EP-4601471-A1 SUBSTITUTED 5-MEMBERED RINGS AND THEIR USE AS PESTICIDES Corteva Agriscience LLC (US) 2025-08-20 — — EP disclosed
US-20250243177-A1 sGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2025-07-31 — — US disclosed
US-20250177397-A1 INHIBITORS OF MPTP NRG THERAPEUTICS LTD (GB) 2025-06-05 — — US disclosed
US-4695579-A Antifungal 2-azolylmethyl-3-difluorobenzyloxy-2,3-dihydrofluoro-benzo(B) thiophens SCHERING CORPORATION (US) 1987-09-22 — — US disclosed
EP-0185381-A2 2-Azolylmethyl-3-difluorobenzyloxy-2,3-dihydrofluorobenzo(b)thiophenes, process for their preparation and compositions containing them SCHERING CORPORATION (US) 1986-06-25 — — EP disclosed
EP-0092628-B1 PROCESS FOR THE PREPARATION OF PHENYL KETONES STARTING FROM HALOGEN OR TRIHALOGEN METHYL BENZENES AND ALIPHATIC OR AROMATIC TRIHALOGEN-METHYL COMPOUNDS RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1985-05-29 — — EP disclosed
EP-0084742-B1 PROCESS FOR THE ACYLATION OF HALOGEN OR TRIHALOGEN METHYL BENZENES RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1985-05-22 — — EP disclosed
US-4454350-A Process for the acylation of halo- or trihalomethylbenzenes RHONE-POULENC SPECIALITIES CHIMIQUES (FR) 1984-06-12 — — US disclosed
US-4453012-A REACTION OF A HALO OR TRIHALOMETHYL BENZENE WITH A TRIHALOMETHYLATED ALIPHATIC OR AROMATIC COMPOUND RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-06-05 — — US disclosed
EP-0092628-A1 Process for the preparation of phenyl ketones starting from halogen or trihalogen methyl benzenes and aliphatic or aromatic trihalogen-methyl compounds RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1983-11-02 — — EP disclosed
EP-0084742-A1 Process for the acylation of halogen or trihalogen methyl benzenes RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1983-08-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570675-B2 Boronic acid compounds PSMB6, PSMB3, PSMB2 TAAR1 1770/4885CES2 712/4885BCHE 308/4885
US-12491185-B2 Inhibitors of mPTP PARK7, PINK1, SNCA TAAR1 728/4885CES2 1079/4885BCHE 1518/4885
US-20250340557-A1 PYRIMIDINE DERIVATIVE PTGES, PTGS1, PTGIS TAAR1 1687/4885CES2 3014/4885BCHE 3193/4885
US-20250177397-A1 INHIBITORS OF MPTP PARK7, PINK1, SNCA TAAR1 728/4885CES2 1079/4885BCHE 1518/4885
US-20260007672-A1 INHIBITORS OF MPTP PARK7, SNCA, CYC1 TAAR1 195/4885CES2 1005/4885BCHE 1603/4885
US-20250243177-A1 sGC STIMULATORS GUCY1A1, PTGIS, GUCY1B1 TAAR1 1623/4885CES2 2825/4885BCHE 2557/4885
US-20080177077-A1 PROCESSES FOR THE PREPARATION OF 3-(4-(2,4-DIFLUOROBENZYLOXY)-3-BROMO-6-METHYL-2-OXOPYRIDIN-1(2H)-YL)-N,4-DIMETHYLBENZAMIDE CYP4X1, CYP4B1, KDM4B TAAR1 2674/4885CES2 861/4885BCHE 2171/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.