Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ampyrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.56 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | CASP6 | P55212 | 2/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ampyrone SCHEMBL4648040 | 0.88 | BCHE (0.60) | BCHEPTGS2ALDH1A1ALOX15PTGS1 | |
| Ampyrone SCHEMBL8822010 | 0.82 | BCHE (0.68) | BCHEPTGS2ALDH1A1ALOX15PTGS1 | |
| Ampyrone SCHEMBL28606780 | 0.79 | BCHE (0.84) | BCHEPTGS2ALDH1A1ALOX15PTGS1 | |
| SCHEMBL396148 | 0.78 | BCHE (0.60) | BCHEPTGS2ALDH1A1ALOX15PTGS1 | |
| SCHEMBL395394 | 0.78 | BCHE (0.62) | BCHEPTGS2ALDH1A1ALOX15PTGS1 | |
| SCHEMBL396551 | 0.75 | BCHE (0.54) | BCHEPTGS2ALDH1A1ALOX15PTGS1 | |
| Ampyrone SCHEMBL128544 | 0.75 | BCHE (1.00) | BCHEPTGS2ALDH1A1ALOX15MAPT | |
| Ampyrone SCHEMBL11674586 | 0.75 | BCHE (1.00) | BCHEPTGS2ALDH1A1ALOX15MAPT | |
| Ampyrone SCHEMBL18159502 | 0.75 | BCHE (1.00) | BCHEPTGS2ALDH1A1ALOX15MAPT | |
| Ampyrone SCHEMBL3092850 | 0.74 | BCHE (0.84) | BCHEPTGS2ALDH1A1ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012163361-A1 | METHOD AND SYSTEM FOR IDENTIFICATION OF PHYSIOLOGICAL IMBALANCE IN AN ANIMAL | AARHUS UNIVERSITET (DK) | 2012-12-06 | — | — | WO | disclosed |
| US-8206944-B2 | Dry stick device construction and method for determining an analyte in a sample using said dry stick device | LATTEC I/S (DK) | 2012-06-26 | — | — | US | disclosed |
| EP-1982182-B1 | A NOVEL DRY STICK DEVICE CONSTRUCTION AND METHOD FOR DETERMINING AN ANALYTE IN A SAMPLE USING SAID DRY STICK DEVICE | LATTEC I S (DK) | 2012-03-07 | — | — | EP | disclosed |
| US-20110039290-A1 | NOVEL DRY STICK DEVICE CONSTRUCTION AND METHOD FOR DETERMINING AN ANALYTE IN A SAMPLE USING SAID DRY STICK DEVICE | LATTEC I/S (DK) | 2011-02-17 | — | — | US | disclosed |
| EP-1982182-A1 | A NOVEL DRY STICK DEVICE CONSTRUCTION AND METHOD FOR DETERMINING AN ANALYTE IN A SAMPLE USING SAID DRY STICK DEVICE | Lattec I/S (DK) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007082544-A1 | A NOVEL DRY STICK DEVICE CONSTRUCTION AND METHOD FOR DETERMINING AN ANALYTE IN A SAMPLE USING SAID DRY STICK DEVICE | LATTEC I/S (DK) | 2007-07-26 | — | — | WO | disclosed |