Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 8/20 | 0.67 |
| ▸ | CES1 | P23141 | 8/20 | 0.67 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30954397 | 1.00 | CES2 (0.67) | CES2CES1BCHEDGAT1MAP2K2 | |
| SCHEMBL19731208 | 0.82 | CES2 (0.61) | CES2CES1BCHEDGAT1MAP2K2 | |
| SCHEMBL382348 | 0.82 | CES2 (0.61) | CES2CES1ALDH1A1KMT2A | |
| SCHEMBL1003016 | 0.81 | CES2 (0.67) | CES2CES1BCHEDGAT1MAP2K2 | |
| SCHEMBL1760850 | 0.80 | CES2 (0.73) | CES2CES1BCHEDGAT1MAP2K2 | |
| SCHEMBL7096567 | 0.79 | CES2 (0.57) | CES2CES1BCHEALDH1A1KMT2A | |
| SCHEMBL241797 | 0.78 | CES2 (0.70) | CES2CES1BCHEMAP2K2MAP2K1 | |
| SCHEMBL7744985 | 0.78 | CES2 (0.70) | CES2CES1BCHEDGAT1MAP2K2 | |
| SCHEMBL4444760 | 0.78 | CES2 (0.70) | CES2CES1BCHEDGAT1MAP2K2 | |
| SCHEMBL16319966 | 0.77 | CES2 (0.55) | CES2CES1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041882-A1 | METHODS FOR SYNTHESIS OF ACYLOXYALKYL COMPOUNDS | XENOPORT, INC. (US) | 2010-02-18 | — | — | US | claimed |
| US-7662987-B2 | Oxidation of 1-acyl alkyl compound under anhydrous condition | XENOPORT, INC. (US) | 2010-02-16 | — | — | US | claimed |
| US-20050070715-A1 | Methods for synthesis of acyloxyalkyl compounds | ARBOR PHARMACEUTICALS, LLC | 2005-03-31 | — | — | US | claimed |
| WO-2005010011-A2 | METHODS OF SYNTHESIS OF ACYLOXYALKYL COMPOUNDS | XENOPORT, INC. (US) | 2005-02-03 | — | — | WO | claimed |
| EP-1501784-B1 | INTEGRATED CHEMICAL PROCESSES FOR INDUSTRIAL UTILIZATION OF SEED OILS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| US-9353057-B2 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| EP-2250143-B1 | METHOD FOR THE ENZYMATIC KINETIC RESOLUTION OF ACYLOXYALKYL THIOCARBONATES USED FOR THE SYNTHESIS OF ACYLOXYALKYL CARBAMATES | XENOPORT INC (US) | 2016-04-20 | — | — | EP | disclosed |
| US-20130131355-A1 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF | XENOPORT, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| EP-1716115-B1 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF | XENOPORT INC (US) | 2013-02-27 | — | — | EP | disclosed |
| US-8378137-B2 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120010425-A1 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF | XENOPORT, INC. (US) | 2012-01-12 | — | — | US | disclosed |
| US-8062870-B2 | Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs | XENOPORT, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-7511158-B2 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20070244331-A1 | Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof | XENOPORT, INC. | 2007-10-18 | — | — | US | disclosed |
| US-7227028-B2 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| US-20070037988-A9 | Formation of a thiocarbamate from a haloformic compound, dehalo-esterification, coupling an N-hydroxysuccinimide or secondary amide-containing drug; prodrugs of gabapentin and baclofen; improved bioavailability | XENOPORT, INC. | 2007-02-15 | — | — | US | disclosed |
| US-20050222431-A1 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. | 2005-10-06 | — | — | US | disclosed |
| US-20050154221-A1 | Integrate chemical processes for industrial utilization of seed oils | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION | 2005-07-14 | — | — | US | disclosed |
| EP-1501784-A1 | INTERGRATED CHEMICAL PROCESSES FOR INDUSTRIAL UTILIZATION OF SEED OILS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093215-A1 | INTERGRATED CHEMICAL PROCESSES FOR INDUSTRIAL UTILIZATION OF SEED OILS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070715-A1 | Methods for synthesis of acyloxyalkyl compounds | AADAC, CYP2D6, CYP3A7 | CES2 14/4885CES1 56/4885BCHE 655/4885 |
| US-20050222431-A1 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | CPS1, ACMSD, NAAA | CES2 17/4885CES1 33/4885BCHE 408/4885 |
| US-20050154221-A1 | Integrate chemical processes for industrial utilization of seed oils | ALOX12, SQLE, ALOX15 | CES2 754/4885CES1 532/4885BCHE 545/4885 |
| US-20130131355-A1 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF | CPS1, ACMSD, NAAA | CES2 17/4885CES1 33/4885BCHE 408/4885 |
| US-20070244331-A1 | Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof | CPS1, ACMSD, NAAA | CES2 17/4885CES1 33/4885BCHE 408/4885 |
| US-20100041882-A1 | METHODS FOR SYNTHESIS OF ACYLOXYALKYL COMPOUNDS | AADAC, CYP2D6, CYP3A7 | CES2 14/4885CES1 56/4885BCHE 655/4885 |
| US-20120010425-A1 | SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF | CPS1, ACMSD, NAAA | CES2 17/4885CES1 33/4885BCHE 408/4885 |
| US-20070037988-A9 | Formation of a thiocarbamate from a haloformic compound, dehalo-esterification, coupling an N-hydroxysuccinimide or secondary amide-containing drug; prodrugs of gabapentin and baclofen; improved bioavailability | SLC6A13, SLC6A11, SLC6A1 | CES2 85/4885CES1 196/4885BCHE 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.