Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HNF4A | P41235 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1882002 | 0.85 | PIK3CA (0.59) | ALDH1A1KDM4ELMNASMN1; SMN2HPGD | |
| SCHEMBL1787541 | 0.84 | USP2 (0.69) | ALDH1A1KDM4ELMNASMN1; SMN2USP2 | |
| SCHEMBL9061917 | 0.82 | PIK3CA (0.53) | ALDH1A1KDM4ELMNASMN1; SMN2HPGD | |
| SCHEMBL5176495 | 0.82 | CYP1A1 (0.60) | ALDH1A1KDM4ELMNASMN1; SMN2HNF4A | |
| SCHEMBL7129795 | 0.82 | MEN1 (0.62) | ALDH1A1LMNAUSP2TP53MEN1 | |
| SCHEMBL1272896 | 0.80 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNASMN1; SMN2HNF4A | |
| SCHEMBL10954405 | 0.80 | G6PD (0.52) | ALDH1A1KDM4ELMNASMN1; SMN2USP2 | |
| SCHEMBL110532 | 0.79 | ALDH1A1 (0.70) | ALDH1A1KDM4ELMNASMN1; SMN2HNF4A | |
| SCHEMBL29457583 | 0.79 | PIK3CA (0.69) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| SCHEMBL3459589 | 0.79 | PIK3CA (0.69) | ALDH1A1KDM4ELMNAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822532-B1 | AQUEOUS POLYURETHANE DISPERSION IN THE TREATMENT OF ACNE | COVESTRO DEUTSCHLAND AG (DE) | 2018-09-19 | — | — | EP | claimed |
| EP-2196469-A1 | Conjugates with anti-inflammatory activity | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2010-06-16 | — | — | EP | claimed |
| EP-1261347-B1 | THERAPEUTIC COMPOSITIONS AND METHODS FOR TREATING PERIODONTITIS WITH ANTIINFLAMATORY COMPOUNDS | UNIV RUTGERS (US) | 2009-09-30 | — | — | EP | claimed |
| EP-1633771-B1 | MACROLIDE-CONJUGATES WITH ANTI-INFLAMMATORY ACTIVITY | GLAXOSMITHKLINE ZAGREB (HR) | 2009-07-15 | — | — | EP | claimed |
| EP-2070940-A1 | Compounds with anti-inflammatory activity | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2009-06-17 | — | — | EP | claimed |
| EP-1617816-B1 | NANOPARTICULATE MELOXICAN FORMULATIONS | ELAN PHARMA INT LTD (IE) | 2009-05-13 | — | — | EP | claimed |
| EP-1551865-B1 | HYBRID MOLECULES OF MACROLIDES WITH STEROIDAL/NON-STEROIDAL ANTI-INFLAMMATORY MOLECULES | GLAXOSMITHKLINE ZAGREB (HR) | 2009-04-22 | — | — | EP | claimed |
| US-20090048221-A1 | Conjugates with Anti-Inflammatory Activity | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2009-02-19 | — | — | US | claimed |
| EP-1805202-A2 | CONJUGATES WITH ANTI-INFLAMMATORY ACTIVITY | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2007-07-11 | — | — | EP | claimed |
| EP-1778292-A2 | USE OF CELL-SPECIFIC CONJUGATES FOR TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-05-02 | — | — | EP | claimed |
| WO-2006018698-A2 | USE OF CELL-SPECIFIC CONJUGATES FOR TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (US) | 2006-02-23 | — | — | WO | claimed |
| US-20060035845-A1 | Use of immune cell specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. | 2006-02-16 | — | — | US | claimed |
| EP-1551865-A2 | HYBRID MOLCULES OF MACROLIDES WITH STEROID/NON-STEROID ANTI-INFLAMMATORY, ANTINEOPLASTIC AND ANTIVIRAL ACTIVE MOLECULES | Pliva - Istrazivacki Institut d.o.o. (HR) | 2005-07-13 | — | — | EP | claimed |
| US-20050080003-A1 | Compounds with anti-inflammatory activity | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2005-04-14 | — | — | US | claimed |
| EP-1521763-A2 | NOVEL NONSTEROIDAL ANTI-INFLAMMATORY SUBSTANCES, COMPOSITIONS AND METHODS FOR THEIR USE | Pliva - Istrazivacki Institut d.o.o. (HR) | 2005-04-13 | — | — | EP | claimed |
| WO-2004094449-A1 | MACROLIDE-CONJUGATES WITH ANTI-INFLAMMATORY ACTIVITY | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (US) | 2004-11-04 | — | — | WO | claimed |
| US-20040097434-A1 | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use | PLIVA PHARMACEUTICAL INDUSTRY, INCORPORATED | 2004-05-20 | — | — | US | claimed |
| US-20040077612-A1 | Novel compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules | PLIVA DD (HR) | 2004-04-22 | — | — | US | claimed |
| WO-2004005313-A2 | HYBRID MOLECULES OF MACROLIDES WITH STEROID/NON-STEROID ANTI-INFLAMMATORY, ANTINEOPLASTIC AND ANTIVIRAL ACTIVE MOLECULES | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (US) | 2004-01-15 | — | — | WO | claimed |
| WO-2004005309-A2 | NOVEL NONSTEROIDAL ANTI-INFLAMMATORY SUBSTANCES, COMPOSITIONS AND METHODS FOR THEIR USE | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (US) | 2004-01-15 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080003-A1 | Compounds with anti-inflammatory activity | NOD1, NOD2, TNF | ALDH1A1 3203/4885KDM4E 3272/4885LMNA 202/4885 |
| US-20060035845-A1 | Use of immune cell specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract | SI, MALT1, CD4 | ALDH1A1 1354/4885KDM4E 1989/4885LMNA 2549/4885 |
| US-20090048221-A1 | Conjugates with Anti-Inflammatory Activity | MPO, EPX, NOD1 | ALDH1A1 2901/4885KDM4E 2438/4885LMNA 190/4885 |
| US-20040097434-A1 | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use | PTGS1, IL1B, LTB4R2 | ALDH1A1 505/4885KDM4E 3705/4885LMNA 802/4885 |
| US-20040077612-A1 | Novel compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules | MALT1, TNF, IL1B | ALDH1A1 2316/4885KDM4E 2444/4885LMNA 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.