Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | ESR1 | P03372 | 1/20 | 0.71 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.71 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.71 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | GGT1 | P19440 | 1/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017487 | 0.85 | PTGS2 (0.74) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL11050544 | 0.85 | KDM4E (0.74) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL189443 | 0.85 | PTGS2 (0.74) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL1939134 | 0.84 | KDM4E (0.67) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL3689374 | 0.84 | KDM4E (0.92) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL10456693 | 0.83 | KDM4E (1.00) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL7580 | 0.83 | KDM4E (1.00) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL1353 | 0.83 | KDM4E (1.00) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL1331740 | 0.83 | KDM4E (1.00) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL29350479 | 0.83 | KDM4E (1.00) | PTGS2KDM4EHSD17B10HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2514739-B1 | Substituted beta-phenyl-alpha-hydroxy propanoic acid, synthesis method and use thereof | UNIV NORTHWEST (CN) | 2016-12-21 | — | — | EP | claimed |
| EP-2514739-A1 | Substituted beta-phenyl-alpha-hydroxy propanoic acid, synthesis method and use thereof | Northwest University (CN) | 2012-10-24 | — | — | EP | claimed |
| US-8017786-B2 | Substituted β-phenyl-α-hydroxy-propanoic acid, synthesis method and use thereof | NORTHWEST UNIVERSITY (CN) | 2011-09-13 | — | — | US | claimed |
| US-20090131677-A1 | SUBSTITUTED BETA-PHENYL-ALPHA-HYDROXY-PROPANOIC ACID, SYNTHESIS METHOD AND USE THEREOF | NORTHWEST UNIVERSITY (CN) | 2009-05-21 | — | — | US | claimed |
| EP-2019090-A1 | SUBSTITUTED BETA-PHENYL-ALPHA-HYDROXY PROPANOIC ACID, SYNTHESIS METHOD AND USE THEREOF | Northwest University (CN) | 2009-01-28 | — | — | EP | claimed |
| WO-2008012603-A1 | POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF DIFLUNISAL AND RELATED COMPOUNDS WITH VERY FAST SKIN PENETRATION RATE | TECHFIELDS BIOCHEM CO. LTD (CN) | 2008-01-31 | — | — | WO | claimed |
| US-20210353579-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | TECHFIELDS PHARMA CO LTD (CN) | 2021-11-18 | — | — | US | disclosed |
| US-20210128561-A1 | MRGX Receptor Antagonists | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2021-05-06 | — | — | US | disclosed |
| US-9872846-B2 | High penetration compositions and uses thereof | TECHFIELDS PHARMA CO., LTD. (CN) | 2018-01-23 | — | — | US | disclosed |
| US-20170209585-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | TECHFIELDS PHARMA CO LTD (CN) | 2017-07-27 | — | — | US | disclosed |
| US-20170209404-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | PREMIER RESEARCH INTERNATIONAL, LLC | 2017-07-27 | — | — | US | disclosed |
| EP-2514739-B1 | Substituted beta-phenyl-alpha-hydroxy propanoic acid, synthesis method and use thereof | UNIV NORTHWEST (CN) | 2016-12-21 | — | — | EP | disclosed |
| EP-2514739-A1 | Substituted beta-phenyl-alpha-hydroxy propanoic acid, synthesis method and use thereof | Northwest University (CN) | 2012-10-24 | — | — | EP | disclosed |
| US-6020426-A | BLOCK OR GRAFT COPOLYMER | FUJI XEROX CO., LTD. (JP) | 2000-02-01 | — | — | US | disclosed |
| US-5973188-A | Acetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-10-26 | — | — | US | disclosed |
| US-5726185-A | BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELET AGGREGATION AND CELL TO CELL ADHESION | HOFFMANN-LA ROCHE INC. (US) | 1998-03-10 | — | — | US | disclosed |
| EP-0379174-A2 | 2,3-Dihydro-3,3-dimethyl-5-trifluoromethanesulfonyloxybenzofurans, process for producing them and herbicides containing them | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-07-25 | — | — | EP | disclosed |
| US-4537856-A | WATER SOLUBLE CHELATE COMPOUND AS STABILIZER | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1985-08-27 | — | — | US | disclosed |
| EP-0094052-A2 | 1-(1,3-Dioxolan-2-yl-methyl)-1H-imidazoles and -1H-1,2,4-triazoles and their salts, process for their preparation, compositions containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-11-16 | — | — | EP | disclosed |
| US-4252738-A | 1,2-Halohydrincarboxylic acid esters and a process for their preparation | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131677-A1 | SUBSTITUTED BETA-PHENYL-ALPHA-HYDROXY-PROPANOIC ACID, SYNTHESIS METHOD AND USE THEREOF | P4HA1, HAO1, PCCA | PTGS2 432/4885KDM4E 3281/4885HSD17B10 115/4885 |
| US-20210128561-A1 | MRGX Receptor Antagonists | MRGPRX2, MRGPRX1, MRGPRX4 | PTGS2 429/4885KDM4E 3530/4885HSD17B10 2366/4885 |
| US-20170209404-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885KDM4E 4795/4885HSD17B10 454/4885 |
| US-20210353579-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885KDM4E 4795/4885HSD17B10 454/4885 |
| US-20170209585-A1 | HIGH PENETRATION COMPOSITIONS AND USES THEREOF | HPGDS, PTGIS, PTGES | PTGS2 7/4885KDM4E 4795/4885HSD17B10 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.