Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 8/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20747115 | 0.85 | MAOB (0.50) | MAOBMAOAGRM5NPC1ALDH1A1 | |
| SCHEMBL4501302 | 0.81 | MAOB (0.41) | MAOBMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25278245 | 0.78 | CYP11B1 (0.33) | CYP11B1CYP11B2SLC22A12 | |
| Chromanone SCHEMBL29384996 | 0.72 | MAOB (0.56) | MAOBMAOAGRM5NPC1ALDH1A1 | |
| SCHEMBL125109 | 0.72 | — | — | |
| SCHEMBL31033492 | 0.72 | — | — | |
| Chromanone SCHEMBL28794 | 0.72 | MAOB (0.56) | MAOBMAOAGRM5NPC1ALDH1A1 | |
| Chromanone SCHEMBL28205525 | 0.72 | MAOB (0.56) | MAOBMAOAGRM5NPC1ALDH1A1 | |
| Chromanone SCHEMBL28463260 | 0.71 | MAOB (0.55) | MAOBMAOAGRM5NPC1ALDH1A1 | |
| Chromanone SCHEMBL29349977 | 0.71 | MAOB (0.55) | MAOBMAOAGRM5NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025021062-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2025-01-30 | — | — | WO | disclosed |
| EP-4426699-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | Boehringer Ingelheim Vetmedica GmbH (DE) | 2024-09-11 | — | — | EP | disclosed |
| US-20240254133-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2024-08-01 | — | — | US | disclosed |
| CN-118339164-A | Insect repellent pyrrolopyridazine compounds | 勃林格殷格翰动物保健有限公司 | 2024-07-12 | — | — | CN | disclosed |
| US-11999742-B2 | Substituted pyrrolo[1,2-b]pyridazines as anthelmintics | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2024-06-04 | — | — | US | disclosed |
| WO-2023073641-A9 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2024-02-29 | — | — | WO | disclosed |
| WO-2023073641-A9 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2024-02-29 | — | — | WO | disclosed |
| US-20230159543-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2023-05-25 | — | — | US | disclosed |
| US-20230159543-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2023-05-25 | — | — | US | disclosed |
| US-20230159543-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2023-05-25 | — | — | US | disclosed |
| WO-2023073641-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2023-05-04 | — | — | WO | disclosed |
| US-8853196-B2 | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-10-07 | — | — | US | disclosed |
| US-20130035323-A1 | AMINOCHROMANE, AMINOTHIOCHROMANE AND AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBOTT GMBH & CO. KG (DE) | 2013-02-07 | — | — | US | disclosed |
| US-7595337-B2 | 2-Carbonyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole derivatives such as 2-acetyl-8-fluoro-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole and 3S,3aS)-2-acetyl-8-chloro-7-methyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole that are useful for treating cancer | MERCK & CO. INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595337-B2 | 2-Carbonyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole derivatives such as 2-acetyl-8-fluoro-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole and 3S,3aS)-2-acetyl-8-chloro-7-methyl-3-phenyl-2,3,3a,4-tetrahydrochromeno[4,3-c]pyrazole that are useful for treating cancer | MERCK & CO. INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-20080182843-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-07-31 | — | — | US | disclosed |
| US-20080182843-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035323-A1 | AMINOCHROMANE, AMINOTHIOCHROMANE AND AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | SLC7A1, BCAT1, AADAT | MAOB 2162/4885MAOA 2749/4885GRM5 1253/4885 |
| US-20080182843-A1 | Mitotic Kinesin Inhibitors | KIF2C, KIF5B, KIF18B | MAOB 4075/4885MAOA 4351/4885GRM5 3530/4885 |
| US-20230159543-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | IL5, EPX, MPO | MAOB 2539/4885MAOA 2702/4885GRM5 802/4885 |
| US-20240254133-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | IL5, EPX, MPO | MAOB 2539/4885MAOA 2702/4885GRM5 802/4885 |
| US-11999742-B2 | Substituted pyrrolo[1,2-b]pyridazines as anthelmintics | IL5, PLPBP, PNPO | MAOB 473/4885MAOA 1647/4885GRM5 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.