Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 6/20 | 0.52 |
| ▸ | CA1 known ✓ | P00915 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316535 | 0.79 | CA2 (0.48) | CA2CA1TSHRGPR84MAPK1 | |
| SCHEMBL10627769 | 0.79 | CA2 (0.39) | CA2CA1TSHRGPR84MAPK1 | |
| SCHEMBL16016004 | 0.79 | CA2 (0.39) | CA2CA1TSHRGPR84MAPK1 | |
| SCHEMBL10591035 | 0.79 | — | — | |
| SCHEMBL319447 | 0.78 | CA2 (0.50) | CA2CA1TSHRMAPK1 | |
| SCHEMBL4338848 | 0.78 | CA1 (0.45) | CA2CA1NFKB1TSHRCYP3A4 | |
| SCHEMBL16006551 | 0.78 | ALDH1A1 (0.38) | CA2CA1TSHRGPR84MAPK1 | |
| SCHEMBL10748206 | 0.77 | CA2 (0.42) | CA2CA1NFKB1GPR84 | |
| SCHEMBL10627704 | 0.76 | CA2 (0.36) | CA2CA1TSHRMAPK1CES1 | |
| SCHEMBL9562158 | 0.74 | CA2 (0.40) | CA2CA1TSHRCYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8651185-B2 | Reducing or stopping the uncontrolled flow of fluid such as oil from a well | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2014-02-18 | — | — | US | claimed |
| US-20120285683-A1 | REDUCING OR STOPPING THE UNCONTROLLED FLOW OF FLUID SUCH AS OIL FROM A WELL | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2012-11-15 | — | — | US | claimed |
| US-8651185-B2 | Reducing or stopping the uncontrolled flow of fluid such as oil from a well | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2014-02-18 | — | — | US | disclosed |
| US-20120285683-A1 | REDUCING OR STOPPING THE UNCONTROLLED FLOW OF FLUID SUCH AS OIL FROM A WELL | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2012-11-15 | — | — | US | disclosed |