SCHEMBL137387

SCHEMBL137387

Cc1ccc2oc(Cl)nc2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.58
NPC1 O15118 8/20 0.58
HPGD P15428 8/20 0.58
KDM4E B2RXH2 8/20 0.58
ALDH1A1 P00352 8/20 0.58
SMN1; SMN2 Q16637 7/20 0.58
HSD17B10 Q99714 5/20 0.58
TP53 P04637 3/20 0.58
CASP3 P42574 3/20 0.54
SENP7 Q9BQF6 3/20 0.54
SENP6 Q9GZR1 3/20 0.54
SENP8 Q96LD8 2/20 0.54
POLB P06746 1/20 0.54
NFKB1 P19838 4/20 0.51
NFKB2 Q00653 4/20 0.51
RELA Q04206 4/20 0.51
LMNA P02545 1/20 0.51
MAPT P10636 5/20 0.50
L3MBTL1 Q9Y468 2/20 0.49
ALOX5 P09917 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2541637 0.84 KDM4E (0.59) RAB9ANPC1HPGDKDM4EALDH1A1
SCHEMBL903255 0.79 NPC1 (0.61) RAB9ANPC1HPGDKDM4EALDH1A1
SCHEMBL29442076 0.79 NPC1 (0.61) RAB9ANPC1HPGDKDM4EALDH1A1
SCHEMBL1672481 0.79 LMNA (0.66) RAB9ANPC1HPGDKDM4EALDH1A1
SCHEMBL9105844 0.79 NPC1 (0.61) RAB9ANPC1HPGDKDM4EALDH1A1
SCHEMBL10829070 0.78 GAA (0.52) RAB9ANPC1HPGDKDM4EALDH1A1
Iodide SCHEMBL8417295 0.78 NPC1 (0.59) RAB9ANPC1HPGDKDM4EALDH1A1
SCHEMBL24133264 0.76 RAB9A (0.58) RAB9ANPC1HPGDKDM4EALDH1A1
SCHEMBL8346086 0.76 NPC1 (0.58) RAB9ANPC1HPGDKDM4EALDH1A1
SCHEMBL9306872 0.76 RAB9A (0.58) RAB9ANPC1HPGDKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-05-13 US disclosed
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-04-08 US disclosed
CN-119264193-A Strong coordination PNN tridentate chiral ligand based on inversion effect and application thereof in free radical asymmetric functionalization and related reaction 武汉大学 2025-01-07 CN disclosed
CN-113382767-B Urea compounds having substituents 第一三共株式会社 2024-12-24 CN disclosed
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors ENANTA PHARM INC (US) 2024-10-31 US disclosed
US-11981686-B2 Urea compound having substituent DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-05-14 US disclosed
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2024-04-09 US disclosed
EP-3687543-B1 COMBINATIONS OF PHARMACEUTICAL AGENTS AS RSV INHIBITORS ENANTA PHARM INC (US) 2024-03-20 EP disclosed
US-20240025906-A1 KINASE MODULATORS AND METHODS OF USE THEREOF SUNDANCE BIOSCIENCES, INC. 2024-01-25 US disclosed
US-20240025906-A1 KINASE MODULATORS AND METHODS OF USE THEREOF SUNDANCE BIOSCIENCES, INC. 2024-01-25 US disclosed
EP-0087701-B1 PROCESS FOR THE PREPARATION OF 2-CHLOROBENZOXAZOLS CASSELLA Aktiengesellschaft (DE) 1986-08-20 EP disclosed
EP-0060426-B1 N-(2,2,2-TRIFLUOROETHYL)-N-ALKYL-AZOLYLOXYACETIC-ACID AMIDES, THEIR PREPARATION AND USE AS HERBICIDES AND INTERMEDIATES FOR THEIR PREPARATION BAYER AG (DE) 1986-04-23 EP disclosed
US-4517370-A Process for preparing 2-chlorobenzoxazoles CASSELLA AKTIENGESELLSCHAFT (DE) 1985-05-14 US disclosed
US-4465504-A Herbicidally active novel N-(2,2,2-trifluoroethyl)-N-alkyl-azolyloxyacetic acid amides and intermediates therefor BAYER AKTIENGESELLSCHAFT (DE) 1984-08-14 US disclosed
US-4455428-A HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1984-06-19 US disclosed
EP-0029171-B1 AZOLYLOXY-CARBOXYLIC ACID N-OXY-AMIDES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE, HERBICIDES CONTAINING THEM AND THEIR PREPARATION BAYER AG (DE) 1984-03-21 EP disclosed
US-4408055-A HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1983-10-04 US disclosed
EP-0087701-A2 Process for the preparation of 2-chlorobenzoxazols CASSELLA Aktiengesellschaft (DE) 1983-09-07 EP disclosed
EP-0081730-A1 Process for the preparation of hetaryloxyacetamides BAYER AG (DE) 1983-06-22 EP disclosed
EP-0060426-A2 N-(2,2,2-trifluoroethyl)-N-alkyl-azolyloxyacetic-acid amides, their preparation and use as herbicides and intermediates for their preparation BAYER AG (DE) 1982-09-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11981686-B2 Urea compound having substituent SIRT6, SIRT1, SIRT2 RAB9A 3232/4885NPC1 1240/4885HPGD 1718/4885
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors GABRA5, GABRA1, GABBR2 RAB9A 1384/4885NPC1 224/4885HPGD 869/4885
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 RAB9A 1384/4885NPC1 224/4885HPGD 869/4885
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 RAB9A 1384/4885NPC1 224/4885HPGD 869/4885
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ACE, ACE2, SPCS3 RAB9A 384/4885NPC1 399/4885HPGD 2245/4885
US-20240025906-A1 KINASE MODULATORS AND METHODS OF USE THEREOF TYK2, JAK1, JAK3 RAB9A 3465/4885NPC1 4600/4885HPGD 3842/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.