Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrocoumarin SCHEMBL28524035 | 0.88 | MAOB (0.46) | MAOBMAOACYP2A6TSHRMAPT | |
| Dihydrocoumarin SCHEMBL29350292 | 0.87 | MAOB (0.50) | MAOBMAOACYP2A6TSHRCYP1A2 | |
| Dihydrocoumarin SCHEMBL28795 | 0.87 | MAOB (0.50) | MAOBMAOACYP2A6TSHRCYP1A2 | |
| Dihydrocoumarin SCHEMBL17629427 | 0.87 | MAOB (0.50) | MAOBMAOACYP2A6TSHRCYP1A2 | |
| SCHEMBL27593934 | 0.87 | KDM4E (0.46) | MAOBMAOACYP2A6TSHRMAPT | |
| Dihydrocoumarin SCHEMBL28721518 | 0.85 | MAOB (0.48) | MAOBMAOACYP2A6TSHRCYP1A2 | |
| Dihydrocoumarin SCHEMBL8888209 | 0.85 | MAOB (0.48) | MAOBMAOACYP2A6TSHRCYP1A2 | |
| Dihydrocoumarin SCHEMBL7617919 | 0.85 | MAOB (0.48) | MAOBMAOACYP2A6TSHRCYP1A2 | |
| SCHEMBL4500547 | 0.84 | MAOA (0.64) | MAOBMAOACYP2A6TSHRMAPT | |
| Dihydrocoumarin SCHEMBL27348538 | 0.83 | MAOB (0.46) | MAOBMAOACYP2A6TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10640481-B2 | Methods for producing Beraprost and its derivatives | LUNG BIOTECHNOLOGY PBC (US) | 2020-05-05 | — | — | US | disclosed |
| US-20190202797-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | LUNG BIOTECHNOLOGY PBC (US) | 2019-07-04 | — | — | US | disclosed |
| US-10246430-B2 | Methods for producing Beraprost and its derivatives | LUNG BIOTECHNOLOGY PBC (US) | 2019-04-02 | — | — | US | disclosed |
| US-10005753-B2 | Methods for producing beraprost and its derivatives | LUNG BIOTECHNOLOGY PBC (US) | 2018-06-26 | — | — | US | disclosed |
| US-10005753-B2 | Methods for producing beraprost and its derivatives | LUNG BIOTECHNOLOGY PBC (US) | 2018-06-26 | — | — | US | disclosed |
| US-20170166545-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | LUNG BIOTECHNOLOGY PBC (US) | 2017-06-15 | — | — | US | disclosed |
| US-20170166545-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | LUNG BIOTECHNOLOGY PBC (US) | 2017-06-15 | — | — | US | disclosed |
| WO-2015179427-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | LUNG BIOTECHNOLOGY PBC (US) | 2015-11-26 | — | — | WO | disclosed |
| EP-2502918-B1 | Pyridazinone Derivatives | CEPHALON INC (US) | 2015-03-25 | — | — | EP | disclosed |
| US-20140142088-A1 | PYRIDAZINONE DERIVATIVES | CEPHALON, INC. (US) | 2014-05-22 | — | — | US | disclosed |
| US-20090012055-A1 | Organic compounds | HEROLD PETER | 2009-01-08 | — | — | US | disclosed |
| EP-1961752-A2 | Piperidine Compounds | Speedel Experimenta AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| US-20080027041-A1 | Pyridizinone derivatives | CEPHALON, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| EP-1851190-A1 | COMPOSITIONS AND METHODS FOR INHIBITING PAIN | University of Florida (US) | 2007-11-07 | — | — | EP | disclosed |
| US-20070010511-A1 | Organic compounds | NOVARTIS PHARMA AG (CH) | 2007-01-11 | — | — | US | disclosed |
| WO-2006078239-A1 | COMPOSITIONS AND METHODS FOR INHIBITING PAIN | UNIVERSITY OF FLORIDA (US) | 2006-07-27 | — | — | WO | disclosed |
| US-20060160905-A1 | Compositions and methods for inhibiting pain | UNIVERSITY OF FLORIDA | 2006-07-20 | — | — | US | disclosed |
| EP-1670760-A1 | ORGANIC COMPOUNDS | Speedel Experimenta AG (CH) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005061457-A1 | ORGANIC COMPOUNDS | SPEEDEL EXPERIMENTA AG (CH) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166545-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | CYP51A1, COASY, BLVRB | MAOB 485/4885MAOA 676/4885CYP2A6 42/4885 |
| US-20090012055-A1 | Organic compounds | REN, ACE, ACE2 | MAOB 43/4885MAOA 85/4885CYP2A6 95/4885 |
| US-20070010511-A1 | Organic compounds | REN, ACE, ACE2 | MAOB 43/4885MAOA 85/4885CYP2A6 95/4885 |
| US-10246430-B2 | Methods for producing Beraprost and its derivatives | UMPS, GGPS1, DHPS | MAOB 971/4885MAOA 1104/4885CYP2A6 458/4885 |
| US-20080027041-A1 | Pyridizinone derivatives | H1-5, H1-3, H1-4 | MAOB 318/4885MAOA 471/4885CYP2A6 640/4885 |
| US-10005753-B2 | Methods for producing beraprost and its derivatives | CYP51A1, COASY, BLVRB | MAOB 485/4885MAOA 676/4885CYP2A6 42/4885 |
| US-10640481-B2 | Methods for producing Beraprost and its derivatives | UMPS, GGPS1, DHPS | MAOB 971/4885MAOA 1104/4885CYP2A6 458/4885 |
| US-20140142088-A1 | PYRIDAZINONE DERIVATIVES | HRH3, HNMT, HRH4 | MAOB 36/4885MAOA 38/4885CYP2A6 328/4885 |
| US-20060160905-A1 | Compositions and methods for inhibiting pain | OPRM1, OPRL1, OPRK1 | MAOB 826/4885MAOA 539/4885CYP2A6 584/4885 |
| US-20190202797-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | UMPS, GGPS1, DHPS | MAOB 971/4885MAOA 1104/4885CYP2A6 458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.