Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 13/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381623 | 0.85 | HTR6 (0.41) | HSD11B1HTR6HTR1AHTR7HTR2C | |
| SCHEMBL1380517 | 0.85 | L3MBTL1 (0.37) | HSD11B1HTR6HTR1AHTR7HTR2C | |
| SCHEMBL1379816 | 0.82 | ALDH1A1 (0.37) | HTR6HTR7RAD52UBE2NL3MBTL1 | |
| SCHEMBL1380174 | 0.81 | RAD52 (0.36) | HTR6HTR1AHTR7HTR2CDRD2 | |
| Trifluoroacetic Acid SCHEMBL1380631 | 0.76 | HTR6 (0.45) | HSD11B1HTR6HTR2BHTR1AHTR7 | |
| SCHEMBL3616367 | 0.72 | HTR6 (0.51) | HSD11B1HTR6HTR2BHTR1AHTR7 | |
| Trifluoroacetic Acid SCHEMBL1381621 | 0.65 | SLC40A1 (0.52) | HSD11B1HTR6RAD52UBE2NL3MBTL1 | |
| SCHEMBL1613542 | 0.64 | ABHD6 (0.38) | HTR6HTR2BHTR1AHTR7HTR2C | |
| Trifluoroacetic Acid SCHEMBL6047104 | 0.63 | SLC40A1 (0.47) | HSD11B1HTR6HTR1AHTR7DRD2 | |
| Trifluoroacetic Acid SCHEMBL1380515 | 0.63 | RAD52 (0.43) | RAD52UBE2NL3MBTL1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4731114-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| EP-1412325-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2004-04-28 | — | — | EP | claimed |
| WO-2002100822-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2002-12-19 | — | — | WO | claimed |