Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 4/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1379816 | 0.87 | ALDH1A1 (0.37) | L3MBTL1RAD52UBE2NSCN9AHTR6 | |
| SCHEMBL1381623 | 0.87 | HTR6 (0.41) | L3MBTL1RAD52UBE2NEPHX2SCN9A | |
| SCHEMBL1380633 | 0.85 | HSD11B1 (0.41) | L3MBTL1RAD52UBE2NBACE1HTR6 | |
| SCHEMBL1380174 | 0.81 | RAD52 (0.36) | L3MBTL1RAD52UBE2NEPHX2PRKD1 | |
| Trifluoroacetic Acid SCHEMBL1380515 | 0.76 | RAD52 (0.43) | L3MBTL1RAD52UBE2NEPHX2BACE1 | |
| SCHEMBL3616470 | 0.71 | MEN1 (0.50) | L3MBTL1PRKD1HTR6HTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL1379813 | 0.66 | HTR6 (0.47) | HTR6KDM4E | |
| Trifluoroacetic Acid SCHEMBL1381621 | 0.65 | SLC40A1 (0.52) | L3MBTL1RAD52UBE2NPRKD1HTR6 | |
| Trifluoroacetic Acid SCHEMBL1380171 | 0.63 | L3MBTL1 (0.43) | L3MBTL1RAD52UBE2NEPHX2PRKD1 | |
| Trifluoroacetic Acid SCHEMBL1380631 | 0.63 | HTR6 (0.45) | L3MBTL1RAD52UBE2NBACE1PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4731114-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| EP-1412325-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2004-04-28 | — | — | EP | claimed |
| WO-2002100822-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2002-12-19 | — | — | WO | claimed |