Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28061468 | 0.85 | CYP2C19 (0.51) | HSD17B10NPC1RAB9ASMN1; SMN2GLA | |
| SCHEMBL9149843 | 0.84 | — | — | |
| SCHEMBL649075 | 0.77 | ALDH1A1 (0.46) | RAB9ASMN1; SMN2ALDH1A1TSHRTDP1 | |
| SCHEMBL7973078 | 0.77 | CYP1A2 (0.55) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1753940 | 0.76 | KCNH2 (0.50) | HSD17B10NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL10824549 | 0.74 | MAPT (0.38) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL24428718 | 0.74 | PPARA (0.32) | HSD17B10NPC1RAB9ASMN1; SMN2GLA | |
| SCHEMBL19830204 | 0.74 | NPC1 (0.32) | HSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20428133 | 0.74 | PPARA (0.32) | HSD17B10NPC1RAB9ASMN1; SMN2GLA | |
| SCHEMBL7974366 | 0.73 | CA2 (0.43) | NPC1RAB9AHPGDCYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3674292-B1 | CLEAVABLE LIPIDS | TRANSLATE BIO INC (US) | 2024-04-10 | — | — | EP | disclosed |
| EP-4212514-A1 | CLEAVABLE LIPIDS | Translate Bio, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| US-20220202718-A1 | Cleavable Lipids | TRANSLATE BIO, INC. | 2022-06-30 | — | — | US | disclosed |
| EP-3998064-A1 | CLEAVABLE LIPIDS | Translate Bio, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |
| US-11234936-B2 | Cleavable lipids | TRANSLATE BIO, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200237671-A1 | Cleavable Lipids | TRANSLATE BIO, INC. | 2020-07-30 | — | — | US | disclosed |
| US-10702478-B2 | Cleavable lipids | TRANSLATE BIO, INC. (US) | 2020-07-07 | — | — | US | disclosed |
| US-10507183-B2 | Cleavable lipids | TRANSLATE BIO, INC. (US) | 2019-12-17 | — | — | US | disclosed |
| US-20190314284-A1 | Cleavable Lipids | TRANSLATE BIO, INC. | 2019-10-17 | — | — | US | disclosed |
| EP-3354644-A1 | CLEAVABLE LIPIDS | Translate Bio, Inc. (US) | 2018-08-01 | — | — | EP | disclosed |
| US-9717690-B2 | Cleavable lipids | RANA THERAPEUTICS, INC. (US) | 2017-08-01 | — | — | US | disclosed |
| US-20140288160-A1 | CLEAVABLE LIPIDS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2014-09-25 | — | — | US | disclosed |
| US-20140288160-A1 | CLEAVABLE LIPIDS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2014-09-25 | — | — | US | disclosed |
| EP-2718269-A1 | CLEAVABLE LIPIDS | Shire Human Genetic Therapies, Inc. (US) | 2014-04-16 | — | — | EP | disclosed |
| WO-2012170889-A9 | CLEAVABLE LIPIDS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2013-12-12 | — | — | WO | disclosed |
| WO-2012170889-A1 | CLEAVABLE LIPIDS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2012-12-13 | — | — | WO | disclosed |
| US-7446120-B2 | Peptidomimetic modulators of cell adhesion | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-11-04 | — | — | US | disclosed |
| US-20080260829-A1 | Bone morphogenic proteins (bmp); cell adhesion modulating agent; peptidomimetics of cyclic peptides comprising classical cadherin cell adhesion recognition (CAR) sequences; modulate cell adhesion and improve drug delivery | NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY (US) | 2008-10-23 | — | — | US | disclosed |
| US-20080081831-A1 | PEPTIDOMIMETIC MODULATORS OF CELL ADHESION | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-04-03 | — | — | US | disclosed |
| US-7268115-B2 | Cyclic peptides; three-dimensional structures; screening; anticancer agents; angiogenesis inhibitors; drug delivery | ADHEREX TECHNOLOGIES, INC. (CA) | 2007-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10507183-B2 | Cleavable lipids | PNLIP, LIPA, SMPD1 | HSD17B10 2962/4885NPC1 31/4885RAB9A 1133/4885 |
| US-10702478-B2 | Cleavable lipids | PNLIP, LIPA, SMPD1 | HSD17B10 3245/4885NPC1 52/4885RAB9A 1270/4885 |
| US-20200237671-A1 | Cleavable Lipids | PTDSS2, ACSS2, SARS1 | HSD17B10 3182/4885NPC1 10/4885RAB9A 1086/4885 |
| US-20220202718-A1 | Cleavable Lipids | PTDSS2, ACSS2, SARS1 | HSD17B10 3182/4885NPC1 10/4885RAB9A 1086/4885 |
| US-20080260829-A1 | Bone morphogenic proteins (bmp); cell adhesion modulating agent; peptidomimetics of cyclic peptides comprising classical cadherin cell adhesion recognition (CAR) sequences; modulate cell adhesion and improve drug delivery | BMP1, BMP2, BMP4 | HSD17B10 4481/4885NPC1 2446/4885RAB9A 248/4885 |
| US-20080081831-A1 | PEPTIDOMIMETIC MODULATORS OF CELL ADHESION | CDH1, EPCAM, VCAM1 | HSD17B10 4125/4885NPC1 4627/4885RAB9A 2023/4885 |
| US-11234936-B2 | Cleavable lipids | PTDSS2, ACSS2, SARS1 | HSD17B10 3182/4885NPC1 10/4885RAB9A 1086/4885 |
| US-20190314284-A1 | Cleavable Lipids | PNLIP, LIPA, SMPD1 | HSD17B10 3245/4885NPC1 52/4885RAB9A 1270/4885 |
| US-20140288160-A1 | CLEAVABLE LIPIDS | PNLIP, LIPA, SMPD1 | HSD17B10 2962/4885NPC1 31/4885RAB9A 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.