SCHEMBL14224894

SCHEMBL14224894

CCC(=O)C(COC(C)(C)C)OCCC(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.35
GRN P28799 1/20 0.30
SORT1 Q99523 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16708419 0.87 MAPK1 (0.33) MAPK1
SCHEMBL26160014 0.80
SCHEMBL25492990 0.73 MAPK1 (0.33) MAPK1
SCHEMBL25795538 0.69 MAPK1 (0.39) MAPK1
SCHEMBL27269211 0.69 MAPK1 (0.36) MAPK1
SCHEMBL1709280 0.68 MAPK1 (0.41) MAPK1GRNSORT1
SCHEMBL1709291 0.68 MAPK1 (0.41) MAPK1GRNSORT1
SCHEMBL14374875 0.64 MAPK1 (0.38) MAPK1GRNSORT1
SCHEMBL179208 0.62 MAPK1 (0.33) MAPK1
SCHEMBL13632327 0.62 MAPK1 (0.39) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240240182-A1 HUMAN CHROMOSOME 9 OPEN READING FRAME 72 (C9ORF72) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2024-07-18 US disclosed
US-20240209339-A1 REDIRECTING RISC FOR RNA EDITING ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240209374-A1 iRNA COMPOSITIONS AND METHODS FOR SILENCING CHITINASE 3-LIKE PROTEIN 1/YKL-40 (CHI3L1/YKL-40) PROTEIN ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240209369-A1 COMPLEMENT COMPONENT C3 IRNA COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2024-06-27 US disclosed
US-20240209373-A1 ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 1 (ELOVL1) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-12018260-B2 Tunable Reversir™ compounds ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-25 US disclosed
US-20240067972-A1 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF BANK OF AMERICA, N.A. 2024-02-29 US disclosed
US-20230332147-A1 IRNA COMPOSITIONS AND METHODS FOR SILENCING GROWTH FACTOR RECEPTOR BOUND PROTEIN 10 (GRB10) OR GROWTH FACTOR RECEPTOR BOUND PROTEIN 14 (GRB14) IN THE LIVER ALNYLAM PHARMACEUTICALS, INC. (US) 2023-10-19 US disclosed
US-20230287424-A1 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION BANK OF AMERICA, N.A. 2023-09-14 US disclosed
US-20230272382-A1 COMPLEMENT COMPONENT C3 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING COMPLEMENT COMPONENT C3-ASSOCIATED DISEASES BANK OF AMERICA, N.A. 2023-08-31 US disclosed
US-20230126233-A1 LEUCINE-RICH REPEAT KINASE 2 (LRRK2) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2023-04-27 US disclosed
US-20230126881-A1 Fc FRAGMENT OF IgG RECEPTOR AND TRANSPORTER (FCGRT) iRNA COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2023-04-27 US disclosed
US-20230125933-A1 MANNAN BINDING LECTIN SERINE PEPTIDASE 2 (MASP2) IRNA COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2023-04-27 US disclosed
US-20180208927-A1 MULTI-TARGETED SINGLE ENTITY CONJUGATES ALNYLAM PHARMACEUTICALS, INC. (US) 2018-07-26 US disclosed
US-20170369872-A1 REVERSIR TM COMPOUNDS ALNYLAM PHARMACEUTICALS, INC. (US) 2017-12-28 US disclosed
US-20170275626-A1 MODIFIED DOUBLE-STRANDED RNA AGENTS BANK OF AMERICA, N.A. 2017-09-28 US disclosed
US-20170226507-A1 COORDINATE CONTROL OF PATHOGENIC SIGNALING BY THE MIR-130/301 FAMILY IN PULMONARY HYPERTENSION AND FIBROPROLIFERATIVE DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2017-08-10 US disclosed
US-20170204411-A1 METHODS AND COMPOSITIONS FOR TREATING INSECTS ALNYLAM PHARMACEUTICALS, INC. (US) 2017-07-20 US disclosed
US-20150011614-A1 METHODS AND COMPOSITIONS FOR TREATING INSECTS ALNYLAM PHARMACEUTICALS, INC. 2015-01-08 US disclosed
US-20120316220-A1 METHODS AND COMPOSITIONS FOR TREATING INSECTS ALNYLAM PHARMACEUTICALS, INC. (US) 2012-12-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230287424-A1 RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION MTREX, RNASEH1, RNASE1 MAPK1 4811/4885GRN 1807/4885SORT1 2134/4885
US-20120316220-A1 METHODS AND COMPOSITIONS FOR TREATING INSECTS MTREX, STING1, AGO2 MAPK1 2836/4885GRN 1834/4885SORT1 3128/4885
US-20240067972-A1 DIPEPTIDYL PEPTIDASE 4 (DPP4) IRNA COMPOSITIONS AND METHODS OF USE THEREOF DPP4, DPP3, DPP7 MAPK1 4702/4885GRN 2509/4885SORT1 1266/4885
US-12018260-B2 Tunable Reversir™ compounds SNRPE, PLK1, LDLR MAPK1 3310/4885GRN 119/4885SORT1 1512/4885
US-20230126233-A1 LEUCINE-RICH REPEAT KINASE 2 (LRRK2) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF LRRK2, EIF2AK2, HIPK2 MAPK1 1593/4885GRN 254/4885SORT1 3457/4885
US-20240209339-A1 REDIRECTING RISC FOR RNA EDITING ADAR, AGO2, METTL16 MAPK1 4476/4885GRN 3266/4885SORT1 1391/4885
US-20240209374-A1 iRNA COMPOSITIONS AND METHODS FOR SILENCING CHITINASE 3-LIKE PROTEIN 1/YKL-40 (CHI3L1/YKL-40) PROTEIN CHI3L1, CHIA, CHI3L2 MAPK1 4097/4885GRN 101/4885SORT1 1063/4885
US-20170204411-A1 METHODS AND COMPOSITIONS FOR TREATING INSECTS MTREX, STING1, AGO2 MAPK1 2836/4885GRN 1834/4885SORT1 3128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.