SCHEMBL1448035

SCHEMBL1448035

CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ACE P12821 2/20 0.59
CTSS P25774 9/20 0.57
CTSK P43235 7/20 0.57
PTPN1 P18031 1/20 0.53
ITGB3 P05106 2/20 0.53
ITGA2B P08514 2/20 0.53
CTSB P07858 2/20 0.49
CTSL P07711 1/20 0.49
PPARA Q07869 5/20 0.48
PPARG P37231 4/20 0.48
ITGB1 P05556 1/20 0.47
ITGAV P06756 1/20 0.47
ITGB5 P18084 1/20 0.47
PPARD Q03181 2/20 0.46
ITGA4 P13612 1/20 0.46
ITGB7 P26010 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14250214 1.00 ACE (0.59) ACECTSSCTSKPTPN1ITGB3
SCHEMBL1202421 1.00 ACE (0.59) ACECTSSCTSKPTPN1ITGB3
SCHEMBL27153880 0.92 ACE (0.55) ACECTSSCTSKPTPN1ITGB3
SCHEMBL27152900 0.92 ACE (0.55) ACECTSSCTSKPTPN1ITGB3
SCHEMBL25186509 0.91 ACE (0.54) ACECTSSCTSKPTPN1ITGB3
SCHEMBL17580003 0.91 ACE (0.54) ACECTSSCTSKPTPN1ITGB3
SCHEMBL20551144 0.88 CTSS (0.54) ACECTSSCTSKPTPN1ITGB3
SCHEMBL20551147 0.88 CTSS (0.54) ACECTSSCTSKPTPN1ITGB3
SCHEMBL21643078 0.88 CTSS (0.57) ACECTSSCTSKPTPN1ITGB3
SCHEMBL21643081 0.88 CTSS (0.57) ACECTSSCTSKPTPN1ITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 407 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116444499-B Phenylalanine derivative containing 4-quinazolinone and preparation method and application thereof 山东大学 2024-09-06 CN claimed
CN-117658990-A 4-quinazolinone derivative containing benzenesulfonamide piperazinone, and preparation method and application thereof 山东大学 2024-03-08 CN claimed
CN-117384240-A HIV-1 capsid protein degradation agent based on hydrophobic tag technology and preparation method and application thereof 山东大学 2024-01-12 CN claimed
CN-116444499-A Phenylalanine derivative containing 4-quinazolinone and preparation method and application thereof 山东大学 2023-07-18 CN claimed
WO-2026107097-A1 SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF ENLAZA THERAPEUTICS, INC. (US) 2026-05-21 WO disclosed
US-12630808-B2 Modified archaeal family b polymerases Singular Genomics Systems, Inc. (US) 2026-05-19 US disclosed
US-20260125660-A1 MODIFIED ARCHAEAL FAMILY B POLYMERASES SINGULAR GENOMICS SYSTEMS INC (US) 2026-05-07 US disclosed
US-12594276-B2 Inhibitors of human immunodeficiency virus replication VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) 2026-04-07 US disclosed
US-20260091017-A1 TREATMENTS FOR INFLAMMATION AUCKLAND UNISERVICES LTD (NZ) 2026-04-02 US disclosed
US-20260085299-A1 ENGINEERED PYROCOCCUS ENZYMES AND USES THEREOF SINGULAR GENOMICS SYSTEMS INC (US) 2026-03-26 US disclosed
US-12564644-B2 Cyclodextrin complexes of specialized proresolving mediators THETIS PHARMACEUTICALS LLC (US) 2026-03-03 US disclosed
EP-4677087-A1 NOVEL TREATMENTS FOR OCULAR DISORDERS Glaukos Corporation (US) 2026-01-14 EP disclosed
US-20030013881-A1 Compounds to treat Alzheimer's disease ELAN PHARMACEUTICALS, INC. 2003-01-16 US disclosed
US-20030004360-A1 Processes and intermediates for preparing benzyl epoxides PHARMACIA & UPJOHN COMPANY 2003-01-02 US disclosed
WO-2002100818-A2 AMINEDIOLS AS AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE ELAN PHARMACEUTICALS, INC. (US) 2002-12-19 WO disclosed
WO-2002100820-A1 SUBSTITUTED AMINOALCOHOLS USEFUL IN TREATMENT OF ALZHEIMER'S DISEASE ELAN PHARMACEUTICALS, INC. (US) 2002-12-19 WO disclosed
EP-1265849-A2 COMPOUNDS AND METHODS TO TREAT ALZHEIMER'S DISEASE Elan Pharmaceuticals, Inc. (US) 2002-12-18 EP disclosed
US-20020022623-A1 Compounds to treat alzheimer's disease ELAN PHARMACEUTICALS, INC. 2002-02-21 US disclosed
US-20020019403-A1 Methods to treat alzheimer's disease ELAN PHARMACEUTICALS, INC. 2002-02-14 US disclosed
WO-2001070672-A2 COMPOUNDS AND METHODS TO TREAT ALZHEIMER'S DISEASE ELAN PHARMACEUTICALS, INC. (US) 2001-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260091017-A1 TREATMENTS FOR INFLAMMATION P2RX7, NLRP3, PYCARD ACE 3545/4885CTSS 614/4885CTSK 583/4885
US-12630808-B2 Modified archaeal family b polymerases SSU72, POLB, POLQ ACE 1258/4885CTSS 3439/4885CTSK 3867/4885
US-12594276-B2 Inhibitors of human immunodeficiency virus replication SAMHD1, IRF3, SLC34A1 ACE 7/4885CTSS 70/4885CTSK 790/4885
US-20030004360-A1 Processes and intermediates for preparing benzyl epoxides CYP2F1, VKORC1, VKORC1L1 ACE 3720/4885CTSS 2132/4885CTSK 2148/4885
US-20020019403-A1 Methods to treat alzheimer's disease PSEN1, PSEN2, BACE1 ACE 181/4885CTSS 1957/4885CTSK 1577/4885
US-20030013881-A1 Compounds to treat Alzheimer's disease PSEN2, PSEN1, BACE1 ACE 164/4885CTSS 2237/4885CTSK 1613/4885
US-20260085299-A1 ENGINEERED PYROCOCCUS ENZYMES AND USES THEREOF POLB, POLM, POLRMT ACE 565/4885CTSS 1137/4885CTSK 2422/4885
US-20020022623-A1 Compounds to treat alzheimer's disease PSEN1, PSEN2, BACE1 ACE 269/4885CTSS 2221/4885CTSK 1785/4885
US-20260125660-A1 MODIFIED ARCHAEAL FAMILY B POLYMERASES DNMT3A, POLB, POLM ACE 663/4885CTSS 2859/4885CTSK 3873/4885
US-12564644-B2 Cyclodextrin complexes of specialized proresolving mediators ALOX15, ALOX12, PTGES ACE 3413/4885CTSS 823/4885CTSK 2120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.