SCHEMBL1458403

SCHEMBL1458403

CC(C)c1cc(Oc2c(Br)cc(OCP(=O)(O)O)cc2Br)ccc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRA P10827 15/20 1.00
THRB P10828 15/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3153545 0.92 THRA (0.85) THRATHRB
SCHEMBL4201863 0.90 THRA (0.81) THRATHRB
SCHEMBL3151602 0.88 THRA (0.79) THRATHRB
SCHEMBL18781782 0.87 THRA (0.77) THRATHRB
SCHEMBL12825218 0.87 THRA (0.78) THRATHRB
SCHEMBL283081 0.87 THRA (1.00) THRATHRB
SCHEMBL21565780 0.86 THRA (0.76) THRATHRB
SCHEMBL282588 0.86 THRB (1.00) THRATHRB
SCHEMBL10274239 0.86 THRA (0.77) THRATHRB
SCHEMBL4212995 0.85 THRA (0.74) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11707472-B2 Compositions for the treatment of fibrosis VIKING THERAPEUTICS, INC. (US) 2023-07-25 US disclosed
US-11707472-B2 Compositions for the treatment of fibrosis VIKING THERAPEUTICS, INC. (US) 2023-07-25 US disclosed
US-20230226038-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISORDERS VIKING THERAPEUTICS, INC. 2023-07-20 US disclosed
US-20230226038-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISORDERS VIKING THERAPEUTICS, INC. 2023-07-20 US disclosed
US-20220016137-A1 COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND INFLAMMATION VIKING THERAPEUTICS, INC. 2022-01-20 US disclosed
US-20220016136-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISORDERS VIKING THERAPEUTICS, INC. 2022-01-20 US disclosed
US-11202789-B2 Method of treating glycogen storage disease VIKING THERAPEUTICS, INC. (US) 2021-12-21 US disclosed
US-20200179412-A1 COMPOSITIONS FOR THE TREATMENT OF FIBROSIS VIKING THERAPEUTICS, INC. 2020-06-11 US disclosed
US-20190343850-A1 METHOD OF TREATING GLYCOGEN STORAGE DISEASE VIKING THERAPEUTICS, INC. (US) 2019-11-14 US disclosed
US-20170112864-A1 Thyromimetics for the Treatment of Fatty Liver Diseases METABASIS THERAPEUTICS, INC. (US) 2017-04-27 US disclosed
US-7514419-B2 Phosphorus-containing thyromimetics METABASIS THERAPEUTICS, INC. (US) 2009-04-07 US disclosed
US-7514419-B2 Phosphorus-containing thyromimetics METABASIS THERAPEUTICS, INC. (US) 2009-04-07 US disclosed
US-20090028925-A1 Novel Phosphinic Acid-Containing Thyromimetics METABASIS THERAPEUTICS, INC. 2009-01-29 US disclosed
US-20090028925-A1 Novel Phosphinic Acid-Containing Thyromimetics METABASIS THERAPEUTICS, INC. 2009-01-29 US disclosed
US-20090028925-A1 Novel Phosphinic Acid-Containing Thyromimetics METABASIS THERAPEUTICS, INC. 2009-01-29 US disclosed
EP-1891080-A2 NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS Metabasis Therapeutics, Inc. (US) 2008-02-27 EP disclosed
EP-1890768-A2 NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS Metabasis Therapeutics, Inc. (US) 2008-02-27 EP disclosed
WO-2006128056-A2 NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS METABASIS THERAPEUTICS, INC. (US) 2006-11-30 WO disclosed
WO-2006128055-A2 NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS METABASIS THERAPEUTICS, INC. (US) 2006-11-30 WO disclosed
US-20060046980-A1 Novel phosphorus-containing thyromimetics METABASIS THERAPEUTICS, INC. 2006-03-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170112864-A1 Thyromimetics for the Treatment of Fatty Liver Diseases TSHR, THRA, FABP1 THRA 2/4885THRB 4/4885
US-20220016136-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISORDERS FABP1, SLC10A1, TSHR THRA 8/4885THRB 7/4885
US-20220016137-A1 COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND INFLAMMATION COL2A1, COL1A1, TGFBR2 THRA 187/4885THRB 30/4885
US-11707472-B2 Compositions for the treatment of fibrosis COL2A1, TGFBR2, COL1A1 THRA 251/4885THRB 33/4885
US-20200179412-A1 COMPOSITIONS FOR THE TREATMENT OF FIBROSIS COL2A1, TGFBR2, COL1A1 THRA 251/4885THRB 33/4885
US-20060046980-A1 Novel phosphorus-containing thyromimetics PYGL, THRA, THOP1 THRA 2/4885THRB 6/4885
US-11202789-B2 Method of treating glycogen storage disease GYS2, GYS1, PYGL THRA 9/4885THRB 7/4885
US-20230226038-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISORDERS FABP1, SLC10A1, LIPC THRA 25/4885THRB 19/4885
US-20190343850-A1 METHOD OF TREATING GLYCOGEN STORAGE DISEASE GYS2, GYS1, PYGL THRA 9/4885THRB 7/4885
US-20090028925-A1 Novel Phosphinic Acid-Containing Thyromimetics PYGL, PHOSPHO1, LIPE THRA 14/4885THRB 41/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.