Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PTGIR | P43119 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720449 | 0.85 | CHRM3 (0.52) | CHRM3LMNAACHECYP3A4CYP2D6 | |
| SCHEMBL14720297 | 0.77 | LIMK2 (0.48) | CHRM3ACHECHRM2OPRD1KMT2A | |
| SCHEMBL14720344 | 0.75 | OPRM1 (0.42) | OPRD1KDM4E | |
| SCHEMBL14720668 | 0.74 | OPRD1 (0.39) | CHRM3HRH3THRBCHRM2OPRD1 | |
| SCHEMBL14720494 | 0.74 | LMNA (0.33) | CHRM3LMNAPTGIR | |
| SCHEMBL14720201 | 0.73 | HDAC1 (0.52) | CHRM3CHRM2KMT2A | |
| SCHEMBL14731355 | 0.73 | FASN (0.58) | — | |
| SCHEMBL14720130 | 0.67 | CHIT1 (0.52) | LMNAKMT2AKDM4E | |
| SCHEMBL20549605 | 0.67 | RAB9A (0.42) | LMNAKMT2A | |
| SCHEMBL20893533 | 0.67 | POLB (0.53) | CYP3A4CYP2D6CYP2C9KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028445-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |