Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.66 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.66 |
| ▸ | P2RY6 known ✓ | Q15077 | 3/20 | 0.47 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.36 |
| ▸ | RAD51 | Q06609 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | LTA | P01374 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.56 |
| ▸ | MIF | P14174 | 2/20 | 0.46 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | RAD1 | O60671 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL3903041 | 0.98 | CA1 (0.63) | CA1CA2RAD51TDP1HSD17B10 | |
| SCHEMBL483832 | 0.83 | CA1 (0.70) | CA1CA2RAD51TDP1HSD17B10 | |
| SCHEMBL4350712 | 0.82 | RAD51 (0.55) | CA1CA2RAD51TDP1HSD17B10 | |
| SCHEMBL3895085 | 0.82 | RAD51 (0.50) | CA1CA2RAD51TDP1HSD17B10 | |
| SCHEMBL31148855 | 0.81 | CYP3A4 (0.48) | CA1CA2RAD51TDP1HSD17B10 | |
| SCHEMBL10907354 | 0.80 | RAD51 (0.53) | CA1CA2RAD51TDP1HSD17B10 | |
| SCHEMBL668791 | 0.79 | CA1 (0.66) | CA1CA2RAD51TDP1HSD17B10 | |
| SCHEMBL31315339 | 0.79 | CA1 (0.66) | CA1CA2RAD51TDP1HSD17B10 | |
| SCHEMBL2891113 | 0.79 | CA1 (0.66) | CA1CA2RAD51TDP1HSD17B10 | |
| SCHEMBL6196292 | 0.79 | CA1 (0.66) | CA1CA2RAD51TDP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543226-B1 | NOVEL IMAGING COMPOSITION AND USES THEREOF | UNIV MELBOURNE (AU) | 2024-03-06 | — | — | EP | disclosed |
| US-11123316-B2 | Imaging composition and uses thereof | THE UNIVERSITY OF MELBOURNE (AU) | 2021-09-21 | — | — | US | disclosed |
| US-20200246286-A1 | NOVEL IMAGING COMPOSITION AND USES THEREOF | THE UNIVERSITY OF MELBOURNE (AU) | 2020-08-06 | — | — | US | disclosed |
| US-10653649-B2 | Imaging composition and uses thereof | THE UNIVERSITY OF MELBOURNE (AU) | 2020-05-19 | — | — | US | disclosed |
| EP-3543226-A1 | NOVEL IMAGING COMPOSITION AND USES THEREOF | The University of Melbourne (AU) | 2019-09-25 | — | — | EP | disclosed |
| US-10398660-B2 | Imaging composition and uses thereof | THE UNIVERSITY OF MELBOURNE (AU) | 2019-09-03 | — | — | US | disclosed |
| EP-3207027-B1 | NOVEL IMAGING COMPOSITION AND USES THEREOF | UNIV MELBOURNE (AU) | 2019-06-19 | — | — | EP | disclosed |
| US-20190099392-A1 | NOVEL IMAGING COMPOSITION AND USES THEREOF | THE UNIVERSITY OF MELBOURNE (AU) | 2019-04-04 | — | — | US | disclosed |
| US-9994444-B2 | Bridged polycyclic compound based compositions for the inhibition and amelioration of disease | ALLACCEM, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-9980930-B2 | Imaging composition and uses thereof | THE UNIVERSITY OF MELBOURNE (AU) | 2018-05-29 | — | — | US | disclosed |
| US-6528528-B2 | Inhibitors of 15-lipoxygenase, inhibiting chemotaxis of monocytes | WARNER-LAMBERT COMPANY | 2003-03-04 | — | — | US | disclosed |
| WO-2002049413-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-27 | — | — | WO | disclosed |
| US-20010031874-A1 | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis | CONNOR DAVID THOMAS (US) | 2001-10-18 | — | — | US | disclosed |
| US-6268387-B1 | INHIBITORS OF THE ENZYME 15-LIPOXYGENASE AND ARE INHIBITORS OF MONOCYTE CHEMOTAXIS. | WARNER-LAMBERT COMPANY | 2001-07-31 | — | — | US | disclosed |
| EP-1042276-A1 | THIOUREA COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY LLC (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032433-A1 | THIOUREA AND BENZAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1999-07-01 | — | — | WO | disclosed |
| US-5280015-A | 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-01-18 | — | — | US | disclosed |
| US-5045478-A | Vesicles and use thereof in an assay | BECTON DICKINSON AND COMPANY (US) | 1991-09-03 | — | — | US | disclosed |
| US-4717676-A | Vesicles and use thereof in an assay | BECTON DICKINSON AND COMPANY (US) | 1988-01-05 | — | — | US | disclosed |
| US-4610954-A | ANTIFOGGING AGENTS | FUJI PHOTO FILM CO., LTD. (JP) | 1986-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200246286-A1 | NOVEL IMAGING COMPOSITION AND USES THEREOF | CA13, CA14, CA12 | CA1 4/4885CA2 33/4885P2RY6 4665/4885 |
| US-20010031874-A1 | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis | TPMT, CTH, CBS | CA1 4089/4885CA2 2286/4885P2RY6 311/4885 |
| US-10653649-B2 | Imaging composition and uses thereof | CA13, CA14, CA12 | CA1 4/4885CA2 30/4885P2RY6 4489/4885 |
| US-10398660-B2 | Imaging composition and uses thereof | CA13, CA14, CA12 | CA1 4/4885CA2 37/4885P2RY6 4437/4885 |
| US-20190099392-A1 | NOVEL IMAGING COMPOSITION AND USES THEREOF | CA13, CA14, CA12 | CA1 4/4885CA2 33/4885P2RY6 4665/4885 |
| US-11123316-B2 | Imaging composition and uses thereof | CA13, CA14, CA12 | CA1 4/4885CA2 30/4885P2RY6 4489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.