SCHEMBL14946181

SCHEMBL14946181

Nc1ccnc2c1ccn2C1OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C1O

nearest known ligand 0.65

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
P2RY2 P41231 18/20 0.65
P2RY4 P51582 5/20 0.60
P2RX3 P56373 1/20 0.60
P2RX2 Q9UBL9 1/20 0.60
P2RY6 Q15077 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14945947 0.91 TAS1R3 (0.56) P2RY2P2RY4P2RY6
SCHEMBL15071507 0.91 TAS1R3 (0.56) P2RY2P2RY4P2RY6
SCHEMBL15248815 0.91 TAS1R3 (0.56) P2RY2P2RY4P2RY6
Tubercidin Triphosphate SCHEMBL12932266 0.87 P2RY1 (0.67) P2RY2P2RY4P2RX3P2RX2
Tubercidin Triphosphate SCHEMBL29357683 0.87 P2RY1 (0.67) P2RY2P2RY4P2RX3P2RX2
SCHEMBL30558659 0.86 P2RY1 (0.66) P2RY2P2RX3P2RX2
SCHEMBL18269535 0.85 P2RX3 (0.73) P2RY2P2RX3P2RX2P2RY6
SCHEMBL16406148 0.84 P2RX3 (0.71) P2RY2P2RX3P2RX2P2RY6
SCHEMBL16406149 0.84 P2RX3 (0.71) P2RY2P2RX3P2RX2P2RY6
SCHEMBL12932260 0.84 P2RY2 (0.66) P2RY2P2RY4P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170252461-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA MODERNATX, INC. 2017-09-07 US disclosed
US-20170175129-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2017-06-22 US disclosed
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Modema Therapeutics, Inc. (US) 2017-05-18 US disclosed
US-20170136132-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2017-05-18 US disclosed
US-20170056528-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF MODERNATX, INC. 2017-03-02 US disclosed
US-20160354493-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX, INC. 2016-12-08 US disclosed
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160354492-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160304552-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. 2016-10-20 US disclosed
US-20160256573-A1 MODIFIED NUCLEIC ACIDS, AND ACUTE CARE USES THEREOF MODERNATX, INC. 2016-09-08 US disclosed
US-20160022840-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA MODERNATX, INC. 2016-01-28 US disclosed
US-20160022774-A1 DIAGNOSIS AND TREATMENT OF FIBROSIS MODERNATX, INC. 2016-01-28 US disclosed
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX, INC. 2015-10-29 US disclosed
US-20150167017-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. 2015-06-18 US disclosed
US-20140378538-A1 METHODS OF RESPONDING TO A BIOTHREAT MODERNATX, INC. 2014-12-25 US disclosed
US-20140371302-A1 MODIFIED MRNAS ENCODING CELL-PENETRATING POLYPEPTIDES MODERNATX, INC. 2014-12-18 US disclosed
US-20140343129-A1 MODIFIED NUCLEIC ACIDS, AND ACUTE CARE USES THEREOF MODERNATX, INC. 2014-11-20 US disclosed
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160354492-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RY2 2899/4885P2RY4 2901/4885P2RX3 3314/4885
US-20160304552-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RY2 2899/4885P2RY4 2901/4885P2RX3 3314/4885
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 P2RY2 558/4885P2RY4 427/4885P2RX3 736/4885
US-20170056528-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 P2RY2 558/4885P2RY4 427/4885P2RX3 736/4885
US-20160022774-A1 DIAGNOSIS AND TREATMENT OF FIBROSIS MMP1, COL2A1, COL1A1 P2RY2 2517/4885P2RY4 2318/4885P2RX3 2167/4885
US-20170136132-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 P2RY2 2786/4885P2RY4 2985/4885P2RX3 2081/4885
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RY2 2899/4885P2RY4 2901/4885P2RX3 3314/4885
US-20160256573-A1 MODIFIED NUCLEIC ACIDS, AND ACUTE CARE USES THEREOF RNMT, NSUN2, NSUN3 P2RY2 1548/4885P2RY4 1471/4885P2RX3 1510/4885
US-20170175129-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 P2RY2 2786/4885P2RY4 2985/4885P2RX3 2081/4885
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 P2RY2 2786/4885P2RY4 2985/4885P2RX3 2081/4885
US-20160354493-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RY2 2899/4885P2RY4 2901/4885P2RX3 3314/4885
US-20160022840-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA RNGTT, NSUN3, CPSF6 P2RY2 3990/4885P2RY4 4549/4885P2RX3 3487/4885
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RY2 2899/4885P2RY4 2901/4885P2RX3 3314/4885
US-20170252461-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA RNGTT, NSUN3, CPSF6 P2RY2 3990/4885P2RY4 4549/4885P2RX3 3487/4885
US-20140378538-A1 METHODS OF RESPONDING TO A BIOTHREAT POLRMT, RNMT, RNGTT P2RY2 2414/4885P2RY4 1610/4885P2RX3 3056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.