SCHEMBL15044550

SCHEMBL15044550

C=C1NC(=O)C(I)=CN1[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
UMPS P11172 4/20 0.52
DNPH1 O43598 1/20 0.47
ATIC P31939 2/20 0.46
GART P22102 1/20 0.46
FBP1 P09467 2/20 0.45
HPRT1 P00492 1/20 0.44
P2RY6 Q15077 3/20 0.44
P2RY2 P41231 2/20 0.44
LDHA P00338 1/20 0.44
IMPDH2 P12268 1/20 0.43
P2RY14 Q15391 2/20 0.43
TAS1R3 Q7RTX0 1/20 0.43
TAS1R1 Q7RTX1 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15071549 1.00 UMPS (0.52) UMPSDNPH1ATICGARTFBP1
SCHEMBL18118150 1.00 UMPS (0.52) UMPSDNPH1ATICGARTFBP1
SCHEMBL14883270 1.00 UMPS (0.52) UMPSDNPH1ATICGARTFBP1
SCHEMBL17809083 1.00 UMPS (0.52) UMPSDNPH1ATICGARTFBP1
SCHEMBL17789093 1.00 UMPS (0.52) UMPSDNPH1ATICGARTFBP1
SCHEMBL14946101 1.00 UMPS (0.52) UMPSDNPH1ATICGARTFBP1
SCHEMBL15745776 0.87 UMPS (0.47) UMPSDNPH1ATICGARTFBP1
SCHEMBL15249855 0.82 UMPS (0.51) UMPSDNPH1ATICGARTFBP1
SCHEMBL15277191 0.80 UMPS (0.48) UMPSDNPH1ATICGARTFBP1
SCHEMBL15257897 0.80 UMPS (0.48) UMPSDNPH1ATICGARTFBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180170990-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS MODERNATX, INC. 2018-06-21 US disclosed
US-20180125937-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS MODERNATX, INC. (US) 2018-05-10 US disclosed
US-20180086807-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE MODERNATX, INC. 2018-03-29 US disclosed
US-20180002393-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES ARES CAPITAL CORPORATION, AS AGENT 2018-01-04 US disclosed
US-20170368200-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS ARES CAPITAL CORPORATION, AS AGENT 2017-12-28 US disclosed
US-20170348436-A1 IN VIVO PRODUCTION OF PROTEINS ARES CAPITAL CORPORATION, AS AGENT 2017-12-07 US disclosed
US-9827332-B2 Modified polynucleotides for the production of proteins MODERNATX, INC. (US) 2017-11-28 US disclosed
US-9828416-B2 Modified polynucleotides for the production of secreted proteins MODERNATX, INC. (US) 2017-11-28 US disclosed
US-9814760-B2 Modified polynucleotides for the production of biologics and proteins associated with human disease MODERNATX, INC. (US) 2017-11-14 US disclosed
US-9790531-B2 Enzymes and polymerases for the synthesis of RNA MODERNATX, INC. (US) 2017-10-17 US disclosed
US-20140141067-A1 MODIFIED POLYNUCLEOTIDES ENCODING SEPTIN-4 MODERNA THERAPEUTICS, INC. (US) 2014-05-22 US disclosed
US-20140105966-A1 MODIFIED POLYNUCLEOTIDES ENCODING HEPATITIS A VIRUS CELLULAR RECEPTOR 2 MODERNA THERAPEUTICS, INC. (US) 2014-04-17 US disclosed
US-20140105964-A1 MODIFIED POLYNUCLEOTIDES ENCODING AQUAPORIN-5 MODERNA THERAPEUTICS, INC. (US) 2014-04-17 US disclosed
US-20140107189-A1 MODIFIED POLYNUCLEOTIDES ENCODING APOPTOSIS INDUCING FACTOR 1 MODERNA THERAPEUTICS, INC. (US) 2014-04-17 US disclosed
US-20130259924-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE modeRNA Therapeutics (US) 2013-10-03 US disclosed
US-20130252281-A1 FORMULATION AND DELIVERY OF PLGA MICROSPHERES modeRNA Therapeutics (US) 2013-09-26 US disclosed
US-20130245107-A1 DLIN-MC3-DMA LIPID NANOPARTICLE DELIVERY OF MODIFIED POLYNUCLEOTIDES modeRNA Therapeutics (US) 2013-09-19 US disclosed
US-20130244279-A1 FORMULATION AND DELIVERY OF PLGA MICROSPHERES modeRNA Therapeutics (US) 2013-09-19 US disclosed
US-20130236974-A1 METHOD FOR INCREASING THE PRODUCTION OF A PROTEIN OF INTEREST modeRNA Therapeutics (US) 2013-09-12 US disclosed
US-20130156849-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS modeRNA Therapeutics (US) 2013-06-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140141067-A1 MODIFIED POLYNUCLEOTIDES ENCODING SEPTIN-4 SEPTIN7, SEPTIN9, SEPTIN8 UMPS 1697/4885DNPH1 2995/4885ATIC 2703/4885
US-20140105964-A1 MODIFIED POLYNUCLEOTIDES ENCODING AQUAPORIN-5 AQP1, AQP3, AQP4 UMPS 504/4885DNPH1 2715/4885ATIC 1049/4885
US-20180170990-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS POLN, POLRMT, MSH2 UMPS 309/4885DNPH1 2509/4885ATIC 712/4885
US-20130236974-A1 METHOD FOR INCREASING THE PRODUCTION OF A PROTEIN OF INTEREST IGF2BP1, PHAX, IGF2BP2 UMPS 1599/4885DNPH1 3597/4885ATIC 235/4885
US-20180125937-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS NSUN2, RNMT, NSUN3 UMPS 175/4885DNPH1 1229/4885ATIC 114/4885
US-20170368200-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS POLRMT, POLN, PHAX UMPS 1052/4885DNPH1 3443/4885ATIC 1192/4885
US-20130156849-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS NSUN2, RNMT, NSUN3 UMPS 175/4885DNPH1 1229/4885ATIC 114/4885
US-20170348436-A1 IN VIVO PRODUCTION OF PROTEINS MSH2, POLRMT, POLN UMPS 492/4885DNPH1 2771/4885ATIC 298/4885
US-20130245107-A1 DLIN-MC3-DMA LIPID NANOPARTICLE DELIVERY OF MODIFIED POLYNUCLEOTIDES NSUN3, PLIN3, MCOLN3 UMPS 2052/4885DNPH1 2646/4885ATIC 1307/4885
US-20180086807-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE POLRMT, POLM, POLN UMPS 357/4885DNPH1 2948/4885ATIC 835/4885
US-20140107189-A1 MODIFIED POLYNUCLEOTIDES ENCODING APOPTOSIS INDUCING FACTOR 1 MSH2, APAF1, MCL1 UMPS 927/4885DNPH1 3739/4885ATIC 2177/4885
US-20180002393-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES MSH2, POLN, MSH6 UMPS 799/4885DNPH1 3073/4885ATIC 1428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.