Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847451 | 0.80 | GSK3A (0.46) | KDM4EALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL15055778 | 0.75 | MEN1 (0.44) | CHRNB2CHRNA4ATMLMNAMAPT | |
| SCHEMBL2687303 | 0.72 | HTT (0.46) | CHRNB2CHRNA4KDM4EUBE2NATM | |
| SCHEMBL15055948 | 0.71 | ALDH1A1 (0.47) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL40506 | 0.69 | LMNA (0.61) | CHRNB2CHRNA4KDM4EUBE2NATM | |
| SCHEMBL2687300 | 0.69 | SIRT2 (0.49) | CHRNB2CHRNA4KDM4EALDH1A1HTT | |
| SCHEMBL16026435 | 0.68 | CHRNB2 (0.85) | CHRNB2CHRNA4KDM4EALDH1A1TDP1 | |
| SCHEMBL8099601 | 0.67 | CHRNB2 (0.70) | CHRNB2CHRNA4KDM4EALDH1A1TDP1 | |
| SCHEMBL9678558 | 0.67 | POLB (0.56) | CHRNB2CHRNA4KDM4EALDH1A1HTT | |
| SCHEMBL15054583 | 0.67 | TSHR (0.45) | KDM4EALDH1A1HTTLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473584-B | Thiophene-or furan-substituted isothiazoline compounds | 勃林格殷格翰动物保健美国公司 | 2020-01-31 | — | — | CN | disclosed |
| US-10407383-B2 | Cyclopentene and cyclopentadiene compounds for controlling invertebrate pests | BASF SE (DE) | 2019-09-10 | — | — | US | disclosed |
| EP-3102563-B1 | CYCLOPENTENE AND CYCLOPENTADIENE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | BASF SE (DE) | 2019-04-10 | — | — | EP | disclosed |
| EP-3013822-B1 | THIOPHENE- OR FURAN-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS AS PESTICIDES | MERIAL INC (US) | 2017-11-01 | — | — | EP | disclosed |
| US-9732051-B2 | Isothiazoline compounds for combating invertebrate pests | BASF SE (DE) | 2017-08-15 | — | — | US | disclosed |
| EP-3102563-A1 | CYCLOPENTENE AND CYCLOPENTADIENE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | BASF SE (DE) | 2016-12-14 | — | — | EP | disclosed |
| US-20160355466-A1 | CYCLOPENTENE AND CYCLOPENTADIENE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | BASF SE (DE) | 2016-12-08 | — | — | US | disclosed |
| US-20160297808-A1 | Thiophene- or furan-substituted isothiazoline Compounds as Pesticides | MERIAL, INC. (US) | 2016-10-13 | — | — | US | disclosed |
| US-20160145223-A1 | Bicyclyl-Substituted Isothiazoline Compounds | BASF SE (DE) | 2016-05-26 | — | — | US | disclosed |
| EP-3013822-A1 | THIOPHENE- OR FURAN-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS AS PESTICIDES | Merial, Inc. (US) | 2016-05-04 | — | — | EP | disclosed |
| EP-3013820-A1 | BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS | BASF SE (DE) | 2016-05-04 | — | — | EP | disclosed |
| WO-2015114157-A1 | CYCLOPENTENE AND CYCLOPENTADIENE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | BASF SE (DE) | 2015-08-06 | — | — | WO | disclosed |
| WO-2014206909-A1 | THIOPHENE- OR FURAN-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS AS PESTICIDES | BASF SE (DE) | 2014-12-31 | — | — | WO | disclosed |
| WO-2014206910-A1 | BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS | BASF SE (DE) | 2014-12-31 | — | — | WO | disclosed |
| US-20140364466-A1 | Isothiazoline compounds for combating invertebrate pests | BASF SE (DE) | 2014-12-11 | — | — | US | disclosed |
| EP-2794601-A1 | ISOTHIAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013092943-A1 | ISOTHIAZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145223-A1 | Bicyclyl-Substituted Isothiazoline Compounds | BROX, TUBA3C, SYMPK | CHRNB2 4489/4885CHRNA4 3617/4885KDM4E 2113/4885 |
| US-20160297808-A1 | Thiophene- or furan-substituted isothiazoline Compounds as Pesticides | PTMS, DDT, PIR | CHRNB2 4534/4885CHRNA4 4041/4885KDM4E 1719/4885 |
| US-10407383-B2 | Cyclopentene and cyclopentadiene compounds for controlling invertebrate pests | PPIE, ECI1, PPID | CHRNB2 3734/4885CHRNA4 3697/4885KDM4E 1216/4885 |
| US-20140364466-A1 | Isothiazoline compounds for combating invertebrate pests | PIR, ACHE, INMT | CHRNB2 4391/4885CHRNA4 3967/4885KDM4E 2046/4885 |
| US-20160355466-A1 | CYCLOPENTENE AND CYCLOPENTADIENE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | PPIE, ECI1, PPID | CHRNB2 3734/4885CHRNA4 3697/4885KDM4E 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.