Sugi Predict

Sugi Predict / Compounds / SCHEMBL150957

SCHEMBL150957

SCHEMBL150957

[CH2]OC(=O)CNc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.45
▸ KMT2A Q03164 4/20 0.45
▸ LMNA P02545 3/20 0.45
▸ MAPT P10636 3/20 0.45
▸ RAB9A P51151 2/20 0.45
▸ MEN1 O00255 2/20 0.45
▸ ERCC1 P07992 3/20 0.44
▸ ERCC4 Q92889 3/20 0.44
▸ SMN1; SMN2 Q16637 2/20 0.44
▸ NPC1 O15118 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ AGTR1 P30556 1/20 0.44
▸ GAA P10253 2/20 0.42
▸ PKM P14618 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.42
▸ AKR1C3 P42330 1/20 0.42
▸ PTPN7 P35236 1/20 0.41
▸ PTPN12 Q05209 1/20 0.41
▸ TP53 P04637 1/20 0.40
▸ EPHX1 P07099 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26135537 0.83 ALDH1A1 (0.47) ALDH1A1KMT2ALMNAMAPTRAB9A
SCHEMBL20594029 0.83 ALDH1A1 (0.47) ALDH1A1KMT2ALMNAMAPTRAB9A
SCHEMBL11884077 0.82 CA1 (0.42) ALDH1A1KMT2AMAPTMEN1HPGD
SCHEMBL658053 0.82 LMNA (0.54) ALDH1A1KMT2ALMNAMAPTRAB9A
SCHEMBL8840792 0.82 ALDH1A1 (0.46) ALDH1A1KMT2ALMNAMAPTRAB9A
SCHEMBL2238017 0.80 ALDH1A1 (0.46) ALDH1A1KMT2ALMNAMAPTRAB9A
SCHEMBL17527568 0.80 ALDH1A1 (0.45) ALDH1A1KMT2ALMNAMAPTRAB9A
SCHEMBL11416059 0.80 ALDH1A1 (0.45) ALDH1A1KMT2ALMNAMAPTRAB9A
Benzene SCHEMBL28330086 0.80 LMNA (0.53) ALDH1A1KMT2ALMNAMAPTRAB9A
Hydrochloric Acid SCHEMBL76327 0.80 LMNA (0.53) ALDH1A1KMT2ALMNAMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1945 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973780-B1 ANTIBACTERIAL SUBSTITUTED 7-ACYLAMINO -3-(METHYLHYDRAZONO) METHYL-CEPHALOSPORINS AND INTERMEDIATES BIOCHEMIE GMBH (AT) 2003-07-02 — — EP claimed
US-6531465-B1 7-acylamino-3-(imino)methyl cephalosporins; 7-[[(5-Amino-1,2,4-thiadiazol-3-yl)-(Z)-(fluormethoxyimino)acetyl]amino]-3-[[(piperazinoiminomethyl)hydrazono]methyl]-3-cephem-4-carboxylic acid; imination of 3-methyl derivative; acylation at the 7-amino; 1-[hydrazino(methylimino)methyl]piperazine intermediate BIOCHEMIE GESELLSCHAFT M.B.H. (AT) 2003-03-11 — — US claimed
US-5055463-A Bactericides MERCK & CO., INC. (US) 1991-10-08 — — US claimed
US-4937253-A LEUKOTRIENE ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1990-06-26 — — US claimed
EP-0365149-A2 Leukotriene antagonist prodrugs SMITHKLINE BEECHAM CORPORATION (US) 1990-04-25 — — EP claimed
EP-0148883-B1 ALLOPURINOL PRODRUGS A/S GEA Farmaceutisk Fabrik (DK) 1990-02-14 — — EP claimed
US-4694006-A Acyl- or acyloxymethyl-allopurinol prodrugs A/S GEA (DK) 1987-09-15 — — US claimed
EP-0148883-A1 ALLOPURINOL PRODRUGS. GEA AS (DK) 1985-07-24 — — EP claimed
WO-1985000368-A1 ALLOPURINOL PRODRUGS A/S GEA (DK) 1985-01-31 — — WO claimed
US-4155912-A 2-Methylpenem-3-carboxylic acid antibiotics BRISTOL-MYERS COMPANY (US) 1979-05-22 — — US claimed
CN-112055711-B Cyclohexylic acid triazolazine as LPA antagonist 百时美施贵宝公司 2024-07-23 — — CN disclosed
US-12037324-B2 Biarylmethyl heterocycles BRISTOL-MYERS SQUIBB COMPANY (US) 2024-07-16 — — US disclosed
US-12037323-B2 Uracil derivatives as Mer-AXL inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2024-07-16 — — US disclosed
US-20240228444-A1 HETEROCYCLIC COMPOUNDS AND RELATED METHODS RECURSION PHARMACEUTICALS, INC. 2024-07-11 — — US disclosed
US-12012374-B2 Agonists of ROR GAMMAt BRISTOL-MYERS SQUIBB COMPANY (US) 2024-06-18 — — US disclosed
US-4041162-A ANTIBIOTICS, BACTERICIDES SMITHKLINE CORPORATION (US) 1977-08-09 — — US disclosed
US-4034092-A ANTIBACTERIAL SMITHKLINE CORPORATION (US) 1977-07-05 — — US disclosed
US-4025626-A ANTIBACTERIAL SMITHKLINE CORPORATION (US) 1977-05-24 — — US disclosed
US-4020057-A 7β-Acyloxy cephalosporins SMITHKLINE CORPORATION (US) 1977-04-26 — — US disclosed
US-3965099-A Cephalosporin esters with antibacterial activity SMITHKLINE CORPORATION (US) 1976-06-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240228444-A1 HETEROCYCLIC COMPOUNDS AND RELATED METHODS CYP11B2, CYP11B1, MAPT ALDH1A1 1053/4885KMT2A 4355/4885LMNA 435/4885
US-12037323-B2 Uracil derivatives as Mer-AXL inhibitors MERTK, DAPK1, AXL ALDH1A1 1072/4885KMT2A 3563/4885LMNA 1982/4885
US-12012374-B2 Agonists of ROR GAMMAt RORB, RORA, RORC ALDH1A1 422/4885KMT2A 1258/4885LMNA 3526/4885
US-12037324-B2 Biarylmethyl heterocycles ARRB1, ADRB2, ADRB1 ALDH1A1 919/4885KMT2A 3170/4885LMNA 3031/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.