Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.50 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28198139 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 | |
| Water SCHEMBL1607914 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 | |
| Water SCHEMBL6438704 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 | |
| Water SCHEMBL28934855 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 | |
| Water SCHEMBL16990187 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 | |
| Water SCHEMBL29431675 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 | |
| Water SCHEMBL28698751 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 | |
| Water SCHEMBL28789165 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 | |
| Water SCHEMBL10958651 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 | |
| Water SCHEMBL27914845 | 1.00 | DNM1 (0.94) | DNM1TSHRALDH1A1THRBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957670-A | Highly-branched cross-linked polysiloxane and waterproof agent | 佛山市顺德区德美瓦克有机硅有限公司 | 2022-08-30 | — | — | CN | claimed |
| US-5620787-A | ALSO CONTAINING AN ALKOXY-GROUP CONTAINING ORGANOSILICON COMPOUND, A SURFACTANT AND WATER | DOW CORNING TORAY SILICONE CO., LTD. (JP) | 1997-04-15 | — | — | US | claimed |
| US-5521238-A | WITH AN ALKOXY-GROUP CONTAINING ORGANOSILICON COMPOUND, SURFACTANT AND WATER; LACK OF OFFENSIVE ODOR; GOOD STORAGE STABILITY; IMPROVES FEEL OF TREATED FIBERS | DOW CORNING TORAY SILICONE CO., LTD. (JP) | 1996-05-28 | — | — | US | claimed |
| US-12583876-B2 | Branched organosilicon compound, method of preparing same, and related compositions | DOW SILICONES CORPORATION (US) | 2026-03-24 | — | — | US | disclosed |
| US-12558299-B2 | Hygiene product pod and methods of using same | CMC Group, Inc. (US) | 2026-02-24 | — | — | US | disclosed |
| US-12539259-B2 | Hygiene product pod and methods of using same | CMC Group, Inc. (US) | 2026-02-03 | — | — | US | disclosed |
| US-12497549-B2 | Composition for preparing a release coating | DOW SILICONES CORPORATION (US) | 2025-12-16 | — | — | US | disclosed |
| US-12398270-B2 | Acrylate-functional branched organosilicon compound, method of preparing same, and copolymer formed therewith | DOW SILICONES CORPORATION (US) | 2025-08-26 | — | — | US | disclosed |
| US-12371535-B2 | Branched organosilicon compound, method of preparing same, and copolymer formed therewith | DOW SILICONES CORPORATION (US) | 2025-07-29 | — | — | US | disclosed |
| US-12365818-B2 | Composition for preparing a release coating | DOW SILICONES CORPORATION (US) | 2025-07-22 | — | — | US | disclosed |
| US-12338259-B2 | Branched organosilicon compound, method of preparing same, and copolymer formed therewith | DOW SILICONES CORPORATION (US) | 2025-06-24 | — | — | US | disclosed |
| US-6153569-A | IN MIXTURE WITH SURFACTANT | DOW CORNING CORPORATION (US) | 2000-11-28 | — | — | US | disclosed |
| US-6147038-A | MIXTURE CONTAINING DIALKYLQUATERNARY AMINE SALT; HAIR CONDITIONER | DOW CORNING CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |
| US-6136896-A | Graft copolymers containing polydiorganosiloxane and polybutylene grafts | DOW CORNING CORPORATION (US) | 2000-10-24 | — | — | US | disclosed |
| EP-1013682-A1 | Graft copolymers containing polydiorganosiloxane and polybutylene grafts | DOW CORNING CORPORATION (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-0995771-A2 | High purity oxyalkylene-modified organopolysiloxanes | DOW CORNING CORPORATION (US) | 2000-04-26 | — | — | EP | disclosed |
| US-5837425-A | PRESENSITIZATION OF PLATES, SUPPORTS, MULTILAYER, EXPOSURE TO ACTINIC RADIATION OF FILMS, DEVELOPMENT OF PLATES WITH ALKALI | FUJI PHOTO FILM CO., LTD. (JP) | 1998-11-17 | — | — | US | disclosed |
| EP-0837104-A2 | Ammonium siloxane emulsions and their use as fiber treatment agents | DOW CORNING CORPORATION (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5707435-A | SOFTENING AGENTS | DOW CORNING CORPORATION (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0716347-A1 | Developer for photosensitive lithographic printing plate | FUJI PHOTO FILM CO., LTD. (JP) | 1996-06-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12539259-B2 | Hygiene product pod and methods of using same | DAGLA, ABHD12, CUTA | THRB 3183/4885SIGMAR1 717/4885DNM1 2369/4885 |
| US-12583876-B2 | Branched organosilicon compound, method of preparing same, and related compositions | OXSR1, BRS3, NPSR1 | THRB 696/4885SIGMAR1 134/4885DNM1 4099/4885 |
| US-12558299-B2 | Hygiene product pod and methods of using same | PLOD2, PLOD1, DDOST | THRB 4036/4885SIGMAR1 1962/4885DNM1 2659/4885 |
| US-12338259-B2 | Branched organosilicon compound, method of preparing same, and copolymer formed therewith | OXSR1, BRS3, ORC3 | THRB 1710/4885SIGMAR1 278/4885DNM1 4287/4885 |
| US-12371535-B2 | Branched organosilicon compound, method of preparing same, and copolymer formed therewith | OXSR1, BRS3, OXER1 | THRB 603/4885SIGMAR1 178/4885DNM1 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.