Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.67 |
| ▸ | PRNP | P04156 | 2/20 | 0.67 |
| ▸ | MTOR | P42345 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.67 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.67 |
| ▸ | NQO2 | P16083 | 1/20 | 0.67 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16261298 | 0.86 | SLC2A1 (0.63) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL18292453 | 0.83 | LMNA (0.71) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL21982991 | 0.83 | LMNA (0.71) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL18292600 | 0.83 | LMNA (0.71) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL2520992 | 0.82 | CDK1 (0.56) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL21983282 | 0.82 | LMNA (0.68) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| Chloroquine SCHEMBL8934 | 0.80 | CHRM2 (1.00) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| Chloroquine SCHEMBL8474661 | 0.80 | CHRM2 (1.00) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| (R)-Chloroquine SCHEMBL134500 | 0.80 | CHRM2 (1.00) | CYP2D6CHRM2CHRM4CHRM5ADRA2A | |
| Chloroquine SCHEMBL8933 | 0.80 | CHRM2 (1.00) | CYP2D6CHRM2CHRM4CHRM5ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| EP-1558254-B1 | USE OF 4-AMINOQUINOLINES COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS OF THE EYE | RAUT RAJEEV (IN) | 2010-12-15 | — | — | EP | claimed |
| US-20060014786-A1 | Opthalmic pharmaceutical compositions and methods for treating ocular inflammation | RAUT RAJEEV | 2006-01-19 | — | — | US | claimed |
| US-20030216431-A1 | Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation | RAUT RAJEEV (IN) | 2003-11-20 | — | — | US | claimed |
| US-20260055116-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | KARUNA THERAPEUTICS INC (US) | 2026-02-26 | — | — | US | disclosed |
| EP-4634194-A1 | SUBSTITUTED DIHYDROPYRROLO [3, 4-D] PYRIMIDINE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Karuna Therapeutics, Inc. (US) | 2025-10-22 | — | — | EP | disclosed |
| EP-4634193-A1 | SUBSTITUTED DIHYDROPYRROLO[3, 4-D]PYRIMIDINE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Karuna Therapeutics, Inc. (US) | 2025-10-22 | — | — | EP | disclosed |
| US-12421242-B2 | Substituted tetrahydropyrrolo-pyridinone compounds and their use in treating medical conditions | Karuna Therapeutics, Inc. (US) | 2025-09-23 | — | — | US | disclosed |
| US-12398119-B2 | Piperazine azaspiro derivatives | PFIZER INC. (US) | 2025-08-26 | — | — | US | disclosed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | disclosed |
| US-12144815-B2 | Use of aprepitant for treating Alzheimer's disease | HOTH THERAPEUTICS, INC. (US) | 2024-11-19 | — | — | US | disclosed |
| US-20240336619-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Karuna Therapeutics, Inc. | 2024-10-10 | — | — | US | disclosed |
| WO-2010059633-A2 | COMPOUNDS FOR TREATING PARASITIC DISEASE | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2010-05-27 | — | — | WO | disclosed |
| WO-2009102570-A2 | TREATMENTS FOR NEUROPATHY | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2009-08-20 | — | — | WO | disclosed |
| US-20090203735-A1 | TREATMENTS FOR NEUROPATHY | NIH-DEITR | 2009-08-13 | — | — | US | disclosed |
| US-7084157-B2 | Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation | RAUT RAJEEV | 2006-08-01 | — | — | US | disclosed |
| US-20060014786-A1 | Opthalmic pharmaceutical compositions and methods for treating ocular inflammation | RAUT RAJEEV | 2006-01-19 | — | — | US | disclosed |
| EP-1558254-A2 | A PROCESS FOR PREPARING PHARMACEUTICAL COMPOSITIONS CONTAINING 4-AMINOQUINOLINES COMPOUNDS FOR TREATMENT OF INFLAMMATORY DISORDERS OF THE EYE, COMPOSITIONS RESULTING THEREFROM | Raut, Rajeev (IN) | 2005-08-03 | — | — | EP | disclosed |
| WO-2003097025-A2 | A PROCESS FOR PREPARING PHARMACEUTICAL COMPOSITIONS CONTAINING 4-AMINOQUINOLINES COMPOUNDS FOR TREATMENT OF INFLAMMATORY DISORDERS OF THE EYE AND COMPOSITIONS RESULTING THEREFROM | RAUT RAJEEV (IN) | 2003-11-27 | — | — | WO | disclosed |
| US-20030216431-A1 | Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation | RAUT RAJEEV (IN) | 2003-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12144815-B2 | Use of aprepitant for treating Alzheimer's disease | TACR1, ACHE, TACR2 | CYP2D6 2294/4885CHRM2 158/4885CHRM4 236/4885 |
| US-12398119-B2 | Piperazine azaspiro derivatives | CHRM1, CHRM2, CHRM5 | CYP2D6 360/4885CHRM2 2/4885CHRM4 5/4885 |
| US-20090203735-A1 | TREATMENTS FOR NEUROPATHY | NGF, BDNF, NTRK2 | CYP2D6 3450/4885CHRM2 866/4885CHRM4 1044/4885 |
| US-20060014786-A1 | Opthalmic pharmaceutical compositions and methods for treating ocular inflammation | AQP4, IL5, CCL11 | CYP2D6 1677/4885CHRM2 653/4885CHRM4 369/4885 |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | TACR1, ACHE, TACR2 | CYP2D6 2294/4885CHRM2 158/4885CHRM4 236/4885 |
| US-20030216431-A1 | Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation | IL5, IL1B, IL4 | CYP2D6 1765/4885CHRM2 1162/4885CHRM4 799/4885 |
| US-20240336619-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | CHRM3, CHRM4, CHRM2 | CYP2D6 164/4885CHRM2 3/4885CHRM4 2/4885 |
| US-12421242-B2 | Substituted tetrahydropyrrolo-pyridinone compounds and their use in treating medical conditions | CHRM3, CHRM4, CHRM2 | CYP2D6 164/4885CHRM2 3/4885CHRM4 2/4885 |
| US-20260055116-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | CHRM3, CHRM2, CHRM1 | CYP2D6 99/4885CHRM2 2/4885CHRM4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.