Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 2/20 | 0.59 |
| ▸ | GABRB2 known ✓ | P47870 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.39 |
| ▸ | IAPP | P10997 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11221611 | 0.96 | GABRA1 (0.59) | GABRA1GABRB2KDM4EALDH1A1HPGD | |
| SCHEMBL11412990 | 0.96 | GABRA1 (0.59) | GABRA1GABRB2KDM4EALDH1A1HPGD | |
| SCHEMBL416813 | 0.87 | HMGB1 (0.47) | GABRA1GABRB2KDM4EALDH1A1HPGD | |
| SCHEMBL10976408 | 0.86 | KDM4E (0.50) | GABRA1GABRB2KDM4EALDH1A1HPGD | |
| SCHEMBL1640151 | 0.84 | IAPP (0.48) | GABRA1GABRB2KDM4EALDH1A1HPGD | |
| SCHEMBL11214708 | 0.84 | HMGB1 (0.47) | GABRA1GABRB2KDM4EALDH1A1HPGD | |
| SCHEMBL11215357 | 0.84 | HMGB1 (0.47) | GABRA1GABRB2KDM4EALDH1A1HPGD | |
| SCHEMBL8878178 | 0.82 | KDM4E (0.45) | GABRA1GABRB2KDM4EALDH1A1HPGD | |
| Zinc Ion SCHEMBL10758632 | 0.82 | ALDH1A1 (0.45) | GABRA1GABRB2KDM4EALDH1A1HPGD | |
| SCHEMBL8877744 | 0.82 | ALDH1A1 (0.54) | GABRA1GABRB2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250041216-A1 | Methotrexate Composition | ROSEMONT PHARMACEUTICALS LTD (GB) | 2025-02-06 | — | — | US | claimed |
| CN-116098978-B | Chinese medicinal cream for treating psoriasis and preparation method thereof | 北京斯利安药业有限公司 | 2024-07-19 | — | — | CN | claimed |
| US-11969503-B2 | Methotrexate composition | ROSEMONT PHARMACEUTICALS LTD (GB) | 2024-04-30 | — | — | US | claimed |
| CN-116139067-B | Method for forming gel by zinc hyaluronate and eye drop gel containing zinc hyaluronate and preparation thereof | 华熙生物科技股份有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-117100626-A | Visual toothpaste for dental plaque | 赛铱高(西安)生物科技有限公司 | 2023-11-24 | — | — | CN | claimed |
| US-20230233464-A1 | Methotrexate Composition | ROSEMONT PHARMACEUTICALS LTD (GB) | 2023-07-27 | — | — | US | claimed |
| CN-116098978-A | Chinese medicinal cream for treating psoriasis and preparation method thereof | 北京斯利安药业有限公司 | 2023-05-12 | — | — | CN | claimed |
| CN-115778897-A | Stable methotrexate pharmaceutical preparation and preparation method thereof | 深圳市贝美药业有限公司 | 2023-03-14 | — | — | CN | claimed |
| CN-115721634-A | Tomoxetine hydrochloride composition, preparation method thereof and application thereof in oral solution | 海南卓科制药有限公司 | 2023-03-03 | — | — | CN | claimed |
| CN-115040475-A | N-acetylcysteine oral solution | 杭州浙中医药科技有限公司 | 2022-09-13 | — | — | CN | claimed |
| US-8795635-B2 | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses | FOAMIX LTD. (IL) | 2014-08-05 | — | — | US | claimed |
| EP-2614814-A1 | Methotrexate composition | Rosemont Pharmaceuticals Ltd (GB) | 2013-07-17 | — | — | EP | claimed |
| US-20130178476-A1 | METHOTREXATE COMPOSITION | ROSEMONT PHARMACEUTICALS LTD (GB) | 2013-07-11 | — | — | US | claimed |
| EP-2257276-A2 | SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES | Foamix Ltd. (IL) | 2010-12-08 | — | — | EP | claimed |
| US-20100221195-A1 | SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES | FOAMIX LTD. (IL) | 2010-09-02 | — | — | US | claimed |
| WO-2009098595-A2 | SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES | FOAMIX LTD. (IL) | 2009-08-13 | — | — | WO | claimed |
| EP-2073794-A2 | STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES | Foamix Ltd. (IL) | 2009-07-01 | — | — | EP | claimed |
| WO-2009007785-A2 | STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES | FOAMIX LTD. (US) | 2009-01-15 | — | — | WO | claimed |
| US-20080260655-A1 | stable, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum, foam agent, propellant, | FOAMIX PHARMACEUTICALS LTD. (IL) | 2008-10-23 | — | — | US | claimed |
| US-20080206155-A1 | STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES | FOAMIX LTD. | 2008-08-28 | — | — | US | claimed |