Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.44 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.44 |
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.38 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | IAPP | P10997 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11215357 | 0.97 | HMGB1 (0.47) | HMGB1IAPPKDM4EALDH1A1HPGD | |
| SCHEMBL11214708 | 0.97 | HMGB1 (0.47) | HMGB1IAPPKDM4EALDH1A1HPGD | |
| SCHEMBL1640151 | 0.90 | IAPP (0.48) | HMGB1IAPPKDM4EALDH1A1HPGD | |
| SCHEMBL1640146 | 0.87 | GABRA1 (0.59) | HMGB1IAPPKDM4EALDH1A1HPGD | |
| SCHEMBL8625728 | 0.87 | IAPP (0.48) | HMGB1IAPPGABRA1GABRB2ELANE | |
| Zinc Ion SCHEMBL1999540 | 0.87 | IAPP (0.48) | HMGB1IAPPGABRA1GABRB2ELANE | |
| SCHEMBL11123537 | 0.84 | BID (0.52) | IAPPKDM4EELANECTSGALOX5 | |
| SCHEMBL11125907 | 0.84 | BID (0.52) | IAPPKDM4EELANECTSGALOX5 | |
| SCHEMBL3517528 | 0.84 | BID (0.52) | IAPPKDM4EELANECTSGALOX5 | |
| SCHEMBL31372911 | 0.84 | BID (0.52) | IAPPKDM4EELANECTSGALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 674 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250041216-A1 | Methotrexate Composition | ROSEMONT PHARMACEUTICALS LTD (GB) | 2025-02-06 | — | — | US | claimed |
| CN-116098978-B | Chinese medicinal cream for treating psoriasis and preparation method thereof | 北京斯利安药业有限公司 | 2024-07-19 | — | — | CN | claimed |
| US-11969503-B2 | Methotrexate composition | ROSEMONT PHARMACEUTICALS LTD (GB) | 2024-04-30 | — | — | US | claimed |
| CN-114762655-B | Oral cavity efficient nursing composition and preparation method and application thereof | 广州赛葆力医疗器械有限公司 | 2024-04-02 | — | — | CN | claimed |
| CN-116942606-A | Preparation method of lamotrigine suspension and dry suspension | 上海奥科达医药科技股份有限公司 | 2023-10-27 | — | — | CN | claimed |
| US-20230233464-A1 | Methotrexate Composition | ROSEMONT PHARMACEUTICALS LTD (GB) | 2023-07-27 | — | — | US | claimed |
| CN-116098978-A | Chinese medicinal cream for treating psoriasis and preparation method thereof | 北京斯利安药业有限公司 | 2023-05-12 | — | — | CN | claimed |
| CN-114948868-B | Crystal form of lamotrigine hydrate, preparation method thereof and composition containing crystal form | 上海奥科达医药科技股份有限公司 | 2023-04-14 | — | — | CN | claimed |
| CN-115400123-A | Tizanidine liquid preparation and application thereof | 四川科瑞德制药股份有限公司 | 2022-11-29 | — | — | CN | claimed |
| CN-112137940-B | Compound sugarcane leaf toothpaste and preparation method thereof | 广西中医药大学 | 2022-11-15 | — | — | CN | claimed |
| CN-1069520-C | Breviscapine soft capsule and its production method | KUNMING PHARMACEUTICAL CO LTD (CN) | 2001-08-15 | — | — | CN | claimed |
| WO-2000050036-A1 | STORAGE STABLE AMOXYCILLIN AND CLAVULANATE SUSPENSION COMPOSITION | BIOVAIL INTERNATIONAL LTD. (US) | 2000-08-31 | — | — | WO | claimed |
| EP-0793495-B1 | FREEZE-DRIED ONDANSETRON COMPOSITIONS | GLAXO WELLCOME INC (CA) | 2000-05-31 | — | — | EP | claimed |
| US-6066629-A | DRY POWDER; MIXTURE CONTAINING LACTAMASE INHIBITOR | FUISZ TECHNOLOGIES LTD. (US) | 2000-05-23 | — | — | US | claimed |
| US-6063802-A | Ondansetron freeze-dried dosage form compositions for oral administration | GLAXCO WELLCOME INC. (CA) | 2000-05-16 | — | — | US | claimed |
| CN-1228958-A | Bulleyaconitine A soft capsule and its production method | KUNMING PHARMACEUTICAL CO LTD (CN) | 1999-09-22 | — | — | CN | claimed |
| CN-1228959-A | Breviscapine soft capsule and its production method | KUNMING PHARMACEUTICAL CO LTD (CN) | 1999-09-22 | — | — | CN | claimed |
| US-5955488-A | ANTAGONIST OF 5-HYDROXYTRYPTAMINE FOR TREATMENT OF EMESIS | GLAXO WELLCOME INC. (CA) | 1999-09-21 | — | — | US | claimed |
| EP-0793495-A1 | FREEZE-DRIED ONDANSETRON COMPOSITIONS | GLAXO WELLCOME INC. (CA) | 1997-09-10 | — | — | EP | claimed |
| WO-1996015785-A1 | FREEZE-DRIED ONDANSETRON COMPOSITIONS | GLAXO WELLCOME INC. (CA) | 1996-05-30 | — | — | WO | claimed |