Nifurpirinol

Nifurpirinol

SCHEMBL1650816

O=[N+]([O-])c1ccc(/C=C/c2cccc(CO)n2)o1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 12/20 0.48
▸ POLB P06746 8/20 0.48
▸ L3MBTL1 Q9Y468 5/20 0.48
▸ TDP1 Q9NUW8 4/20 0.48
▸ MEN1 O00255 10/20 0.45
▸ ALDH1A1 P00352 8/20 0.45
▸ LMNA P02545 7/20 0.45
▸ SMN1; SMN2 Q16637 7/20 0.45
▸ NPC1 O15118 5/20 0.45
▸ RAB9A P51151 5/20 0.45
▸ NPSR1 Q6W5P4 5/20 0.45
▸ RXFP1 Q9HBX9 1/20 0.45
▸ GLO1 Q04760 1/20 0.44
▸ MAPT P10636 7/20 0.43
▸ HTT P42858 7/20 0.43
▸ CYP3A4 P08684 3/20 0.43
▸ CYP1A2 P05177 2/20 0.43
▸ CYP2D6 P10635 2/20 0.43
▸ HSP90AA1 P07900 1/20 0.43
▸ CYP2C9 P11712 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nifurpirinol SCHEMBL148540 1.00 KMT2A (0.48) KMT2APOLBL3MBTL1TDP1MEN1
Nifurpirinol SCHEMBL28198718 0.80 MITF (0.45) KMT2APOLBTDP1MEN1ALDH1A1
Nifurquinazol SCHEMBL28198699 0.79 KMT2A (0.44) KMT2APOLBL3MBTL1TDP1MEN1
SCHEMBL28433359 0.75 KMT2A (0.61) KMT2APOLBL3MBTL1TDP1MEN1
SCHEMBL28433360 0.75 KMT2A (0.61) KMT2APOLBL3MBTL1TDP1MEN1
SCHEMBL31649237 0.74 NPC1 (0.58) KMT2APOLBL3MBTL1TDP1MEN1
Acetic Acid SCHEMBL4458658 0.71 KMT2A (0.56) KMT2APOLBL3MBTL1TDP1MEN1
Acetic Acid SCHEMBL4458652 0.71 KMT2A (0.56) KMT2APOLBL3MBTL1TDP1MEN1
Acetic Acid SCHEMBL4458660 0.71 KMT2A (0.56) KMT2APOLBL3MBTL1TDP1MEN1
SCHEMBL10643025 0.70 KMT2A (0.55) KMT2APOLBL3MBTL1TDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124192-A1 COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING RNA VIRAL INFECTIONS MODEL MEDICINES INC (US) 2026-05-07 — — US disclosed
US-20260102384-A1 USE OF PIPENDOXIFENE FOR TREATING INFECTIONS OF DNA VIRUSES MODEL MEDICINES INC (US) 2026-04-16 — — US disclosed
EP-4706650-A1 COMPOUNDS FOR USE IN THE TREATMENT OF KIDNEY DISEASES Universitätsmedizin Greifswald (DE) 2026-03-11 — — EP disclosed
US-12551475-B2 Methods and compositions for treating RNA viral infections MODEL MEDICINES, INC. (US) 2026-02-17 — — US disclosed
EP-4667008-A2 METHODS AND COMPOSITIONS FOR TREATING RNA VIRAL INFECTIONS Model Medicines, Inc. (US) 2025-12-24 — — EP disclosed
US-20250221388-A1 SYSTEMS AND PROCESSES FOR AQUACULTURE CROP ROTATION NESTE OYJ (FI) 2025-07-10 — — US disclosed
US-20250152703-A1 COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-05-15 — — US disclosed
CN-115379759-B Method for controlling pests, pest control agent composition, and pest control agent set 日本曹达株式会社 2025-03-14 — — CN disclosed
US-20250066712-A1 PROCESSES AND SYSTEMS FOR CULTURING ALGAE OR REDUCING PATHOGENIC MICROBES FROM AN AQUEOUS MEDIUM, AS WELL AS CONCENTRATES AND USES RELATED THERETO NESTE OYJ (FI) 2025-02-27 — — US disclosed
US-20250025454-A1 USE OF PIPENDOXIFENE TO TREAT SARS-COV-2 INFECTION MODEL MEDICINES INC (US) 2025-01-23 — — US disclosed
WO-2023218707-A1 EXHAUST GAS TREATMENT SYSTEM, POWER GENERATION FACILITY COMPRISING SAME, AND EXHAUST GAS TREATMENT METHOD 三菱重工業株式会社 2023-11-16 — — WO disclosed
US-20230346792-A1 COMPOSITIONS AND METHODS FOR TREATING LUNG INFLAMMATION HOTH THERAPEUTICS, INC. 2023-11-02 — — US disclosed
US-20230248712-A1 METHODS AND COMPOSITIONS FOR TREATING RNA VIRAL INFECTIONS MODEL MEDICINES, INC. 2023-08-10 — — US disclosed
US-11672818-B2 Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2023-06-13 — — US disclosed
EP-4157448-A1 METHODS AND COMPOSITIONS FOR TREATING RNA VIRAL INFECTIONS Model Medicines, Inc. (US) 2023-04-05 — — EP disclosed
US-11529312-B2 Francisella lipids as broad anti-inflammatory therapeutics and associated methods of use THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-12-20 — — US disclosed
WO-2022159763-A1 SARS-COV-2 THERAPEUTICS MODEL MEDICINES, INC. (US) 2022-07-28 — — WO disclosed
WO-2017133517-A1 PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF 四川海思科制药有限公司 2017-08-10 — — WO disclosed
US-7927613-B2 Pharmaceutical co-crystal compositions UNIVERSITY OF SOUTH FLORIDA (US) 2011-04-19 — — US disclosed
US-7790905-B2 Pharmaceutical propylene glycol solvate compositions MCNEIL-PPC, INC. (US) 2010-09-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12551475-B2 Methods and compositions for treating RNA viral infections SARS1, EIF2AK2, SNRPE KMT2A 1780/4885POLB 149/4885L3MBTL1 2685/4885
US-20260102384-A1 USE OF PIPENDOXIFENE FOR TREATING INFECTIONS OF DNA VIRUSES ESR1, VDR, POLL KMT2A 1831/4885POLB 29/4885L3MBTL1 3666/4885
US-11672818-B2 Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto NOS1, NOS2, NOS3 KMT2A 4709/4885POLB 4533/4885L3MBTL1 3969/4885
US-20260124192-A1 COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING RNA VIRAL INFECTIONS SARS1, NSUN2, NSUN3 KMT2A 1708/4885POLB 306/4885L3MBTL1 3449/4885
US-20250025454-A1 USE OF PIPENDOXIFENE TO TREAT SARS-COV-2 INFECTION EIF2AK2, ACE2, SARS1 KMT2A 1615/4885POLB 45/4885L3MBTL1 4271/4885
US-11529312-B2 Francisella lipids as broad anti-inflammatory therapeutics and associated methods of use FPR2, FPR1, PLA2G4C KMT2A 4324/4885POLB 3111/4885L3MBTL1 2248/4885
US-20230346792-A1 COMPOSITIONS AND METHODS FOR TREATING LUNG INFLAMMATION ACE2, TMPRSS2, VIPR1 KMT2A 2320/4885POLB 2300/4885L3MBTL1 4238/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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