SCHEMBL166716

SCHEMBL166716

Fc1cccc(C2CCCN2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.53
CHRNA7 P36544 2/20 0.53
CHRNA4 P43681 2/20 0.53
L3MBTL1 Q9Y468 1/20 0.47
MEN1 O00255 2/20 0.47
CYP2D6 P10635 2/20 0.47
CYP2C19 P33261 2/20 0.47
KMT2A Q03164 2/20 0.47
POLB P06746 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2A6 P11509 1/20 0.47
CYP2C9 P11712 1/20 0.47
KCNH2 Q12809 1/20 0.45
CHRM5 P08912 3/20 0.42
CHRM3 P20309 3/20 0.42
CHRM1 P11229 2/20 0.42
CHRM2 P08172 2/20 0.42
CHRM4 P08173 2/20 0.42
HCRTR2 O43614 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29450150 1.00 CHRNB2 (0.53) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
SCHEMBL3503155 1.00 CHRNB2 (0.53) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
SCHEMBL433220 1.00 CHRNB2 (0.53) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
Hydrochloric Acid SCHEMBL450686 0.98 CHRNB2 (0.51) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
Hydrochloric Acid SCHEMBL450685 0.98 CHRNB2 (0.51) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
SCHEMBL433482 0.95 MEN1 (0.54) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
SCHEMBL21523837 0.87 CHRNB2 (0.48) CHRNB2CHRNA4CYP2D6CA1
SCHEMBL29891721 0.87 CHRNB2 (0.41) CHRNB2CHRNA7CHRNA4L3MBTL1MEN1
SCHEMBL30459488 0.83 CA1 (0.42) CHRNB2CHRNA7CHRNA4KMT2ASMN1; SMN2
SCHEMBL432589 0.83 CA1 (0.39) CHRNB2CHRNA7CHRNA4MEN1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4736882-A2 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE Cullgen (Shanghai), Inc. (CN) 2026-05-06 EP disclosed
EP-3841098-B1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2026-01-14 EP disclosed
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2025-12-25 US disclosed
US-20240400570-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2024-12-05 US disclosed
US-12065442-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use CULLGEN (SHANGHAI), INC. (CN) 2024-08-20 US disclosed
CN-115605463-B Inhibitors of receptor-interacting protein kinase I for the treatment of diseases 德州大学系统董事会 2024-08-09 CN disclosed
WO-2024140971-A1 BICYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF 广州市联瑞制药有限公司 2024-07-04 WO disclosed
US-20240174634-A1 Aldehyde Dehydrogenase Inhibitors and Their Therapeutic Use CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-30 US disclosed
US-11969472-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use CULLGEN (SHANGHAI), INC. (CN) 2024-04-30 US disclosed
US-20240132500-A1 METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS ARRAY BIOPHARMA INC (US) 2024-04-25 US disclosed
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS, INC. 2007-07-05 US disclosed
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS, INC. 2007-07-05 US disclosed
WO-2007006547-A1 AMIDE DERIVATIVES AS KINASE INHIBITORS DEVGEN N.V. (BE) 2007-01-18 WO disclosed
WO-2006067589-A1 MACROLIDES PFIZER PRODUCTS INC. (US) 2006-06-29 WO disclosed
WO-2006068594-A1 HETEROCYCLIC MCHr1 ANTAGONISTS AND THEIR USE IN THERAPY ASTRAZENECA AB (SE) 2006-06-29 WO disclosed
US-20060135447-A1 Macrolides CHUPAK LOUIS S 2006-06-22 US disclosed
EP-1165510-B1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS HOFFMANN LA ROCHE (CH) 2005-09-28 EP disclosed
EP-1165510-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2002-01-02 EP disclosed
US-6284785-B1 HAVING ACTIVITY AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS HOFFMANN- LA ROCHE INC. 2001-09-04 US disclosed
WO-2000058285-A1 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2000-10-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11969472-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use MUSK, ERBB2, NTRK1 CHRNB2 311/4885CHRNA7 833/4885CHRNA4 1126/4885
US-20240132500-A1 METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS TYMP, TYMS, P2RX7 CHRNB2 1219/4885CHRNA7 346/4885CHRNA4 979/4885
US-20060135447-A1 Macrolides LCAT, NOP2, HDAC6 CHRNB2 4818/4885CHRNA7 4558/4885CHRNA4 4647/4885
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE ERBB2, MUSK, ERBB3 CHRNB2 126/4885CHRNA7 363/4885CHRNA4 259/4885
US-20240400570-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 CHRNB2 311/4885CHRNA7 833/4885CHRNA4 1126/4885
US-12065442-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use MUSK, NTRK1, ERBB2 CHRNB2 238/4885CHRNA7 538/4885CHRNA4 879/4885
US-20240174634-A1 Aldehyde Dehydrogenase Inhibitors and Their Therapeutic Use ALDH2, ALDH1A1, ALDH3A1 CHRNB2 4668/4885CHRNA7 4394/4885CHRNA4 4226/4885
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 CHRNB2 4856/4885CHRNA7 4876/4885CHRNA4 4862/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.