SCHEMBL1668130

SCHEMBL1668130

N#Cc1cccc(F)c1B(O)O

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 2/20 0.37
BCAT1 P54687 1/20 0.36
TSHR P16473 1/20 0.34
TRPV4 Q9HBA0 2/20 0.34
MCL1 Q07820 1/20 0.34
KAT6A Q92794 1/20 0.34
PDK2 Q15119 1/20 0.33
CUL4A Q13619 1/20 0.33
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
ESR2 Q92731 1/20 0.32
LMNA P02545 1/20 0.32
CES2 O00748 1/20 0.31
CES1 P23141 1/20 0.31
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29950793 1.00 ENPP2 (0.37) ENPP2BCAT1TSHRTRPV4MCL1
SCHEMBL5784673 0.85 ENPP2 (0.43) ENPP2TSHRMCL1PDK2CA1
SCHEMBL146988 0.78 CES2 (0.42) ENPP2CES2CES1
SCHEMBL25493988 0.78 ENPP2 (0.38) ENPP2TSHRCA1CA2ESR2
Boric Acid SCHEMBL29090056 0.77 TSHR (0.43) BCAT1TSHRTRPV4KAT6APDK2
SCHEMBL29950680 0.76 DYRK1A (0.41) ENPP2TSHRTRPV4CA1CA2
SCHEMBL30581690 0.76 TRPV4 (0.38) ENPP2TRPV4ESR2CYP11B1CYP11B2
SCHEMBL26129679 0.76 TRPV4 (0.38) ENPP2TRPV4ESR2CYP11B1CYP11B2
SCHEMBL29741613 0.76 TSHR (0.54) ENPP2TSHRCA1CA2ESR2
SCHEMBL15873452 0.73 AR (0.34) PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109715-A1 IMIDAZOPYRIDINE DERIVATIVES WITH BICYCLIC STRUCTURE PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (JP) 2026-04-23 US disclosed
EP-4720044-A1 AROMATIC AMIDES AND CONJUGATES THEREOF AS BINDERS TO TEAD Beactica Therapeutics AB (SE) 2026-04-08 EP disclosed
US-12552804-B2 Tricyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2026-02-17 US disclosed
EP-4600246-A1 IMIDAZOPYRIDINE DERIVATIVES WITH BICYCLIC STRUCTURE Public University Corporation Yokohama City University (JP) 2025-08-13 EP disclosed
US-12264159-B2 Functionalized heterocycles as antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2025-04-01 US disclosed
WO-2024240840-A1 AROMATIC AMIDES AND CONJUGATES THEREOF AS BINDERS TO TEAD BEACTICA THERAPEUTICS AB (SE) 2024-11-28 WO disclosed
US-20240287086-A1 TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2024-08-29 US disclosed
US-20240262828-A1 Functionalized Heterocycles as Antiviral Agents ENANTA PHARM INC (US) 2024-08-08 US disclosed
CN-117946080-A Organic molecules, in particular for organic optoelectronic devices 三星显示有限公司 2024-04-30 CN disclosed
WO-2024075696-A1 IMIDAZOPYRIDINE DERIVATIVES WITH BICYCLIC STRUCTURE 公立大学法人横浜市立大学 2024-04-11 WO disclosed
EP-2970313-A1 SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS Janssen Pharmaceutica N.V. (BE) 2016-01-20 EP disclosed
EP-2970314-A1 SUBSTITUTED 2-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS Janssen Pharmaceutica, N.V. (BE) 2016-01-20 EP disclosed
WO-2014165070-A1 SUBSTITUTED 2-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-10-09 WO disclosed
WO-2014165065-A1 SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-10-09 WO disclosed
WO-2014159591-A1 SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-10-02 WO disclosed
US-8278460-B2 Substituted benzimidazoles CONCERT PHARMACEUTICALS, INC. (US) 2012-10-02 US disclosed
US-20110172280-A1 Substituted Benzimidazoles CONCERT PHARMACEUTICALS, INC. (US) 2011-07-14 US disclosed
WO-2011047315-A1 SUBSITITUTED BENZIMIDAZOLES CONCERT PHARMACEUTICALS, INC. (US) 2011-04-21 WO disclosed
US-20110082147-A1 SUBSTITUTED IMIDAZOTRIAZINES CONCERT PHARMACEUTICALS, INC. (US) 2011-04-07 US disclosed
US-20110082147-A1 SUBSTITUTED IMIDAZOTRIAZINES CONCERT PHARMACEUTICALS, INC. (US) 2011-04-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240262828-A1 Functionalized Heterocycles as Antiviral Agents HCCS, HAVCR2, HDGF ENPP2 3296/4885BCAT1 35/4885TSHR 3380/4885
US-20110082147-A1 SUBSTITUTED IMIDAZOTRIAZINES GABRA5, GABRA3, GABRA2 ENPP2 1580/4885BCAT1 733/4885TSHR 340/4885
US-20260109715-A1 IMIDAZOPYRIDINE DERIVATIVES WITH BICYCLIC STRUCTURE SMG1, RACK1, TIA1 ENPP2 4665/4885BCAT1 1453/4885TSHR 2185/4885
US-20240287086-A1 TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR3, FGFR1, FGFR2 ENPP2 3169/4885BCAT1 945/4885TSHR 2116/4885
US-12552804-B2 Tricyclic heterocycles as FGFR inhibitors FGFR3, FGFR1, FGFR2 ENPP2 4179/4885BCAT1 939/4885TSHR 750/4885
US-20110172280-A1 Substituted Benzimidazoles GABRA5, GABRB1, GABRA4 ENPP2 2824/4885BCAT1 247/4885TSHR 1444/4885
US-12264159-B2 Functionalized heterocycles as antiviral agents HCCS, HAVCR2, HDGF ENPP2 3296/4885BCAT1 35/4885TSHR 3380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.