Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | CTRC | Q99895 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31332406 | 0.85 | EPHX2 (0.57) | EPHX2SIGMAR1GAADDB1CRBN | |
| SCHEMBL9870393 | 0.82 | KDM4E (0.50) | SIGMAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL8024414 | 0.82 | SIGMAR1 (0.58) | EPHX2SIGMAR1GAADDB1CRBN | |
| SCHEMBL2438031 | 0.81 | SIGMAR1 (0.60) | SIGMAR1GAAALDH1A1ACHETDP1 | |
| SCHEMBL4447555 | 0.81 | ALDH1A1 (0.58) | EPHX2SIGMAR1GAADDB1CRBN | |
| SCHEMBL9871055 | 0.79 | ACHE (0.57) | MEN1KMT2AALDH1A1ACHETDP1 | |
| SCHEMBL1011633 | 0.78 | DDB1 (0.69) | EPHX2GAADDB1CRBNMEN1 | |
| SCHEMBL9850086 | 0.78 | DDB1 (0.69) | EPHX2GAADDB1CRBNMEN1 | |
| SCHEMBL220097 | 0.78 | SIGMAR1 (0.62) | SIGMAR1GAADDB1CRBNMEN1 | |
| SCHEMBL10232320 | 0.78 | LMNA (0.48) | EPHX2SIGMAR1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491021-B1 | NOVEL ACYLPIPERAZINONES AND THEIR USE AS PHARMACEUTICALS | FAB PHARMA SAS (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2491021-B1 | NOVEL ACYLPIPERAZINONES AND THEIR USE AS PHARMACEUTICALS | FAB PHARMA SAS (FR) | 2014-04-23 | — | — | EP | disclosed |
| US-8623865-B2 | Acylpiperazinones and their use as pharmaceuticals | FAB PHARMA S.A.S. (FR) | 2014-01-07 | — | — | US | disclosed |
| US-8623865-B2 | Acylpiperazinones and their use as pharmaceuticals | FAB PHARMA S.A.S. (FR) | 2014-01-07 | — | — | US | disclosed |
| US-20130137689-A1 | NOVEL ACYLPIPERAZINONES AND THEIR USE AS PHARMACEUTICALS | FAB PHARMA S.A.S. (FR) | 2013-05-30 | — | — | US | disclosed |
| US-20130137689-A1 | NOVEL ACYLPIPERAZINONES AND THEIR USE AS PHARMACEUTICALS | FAB PHARMA S.A.S. (FR) | 2013-05-30 | — | — | US | disclosed |
| US-8383621-B2 | Acylpiperazinones and their use as pharmaceuticals | FAB PHARMA S.A.S. (FR) | 2013-02-26 | — | — | US | disclosed |
| US-8383621-B2 | Acylpiperazinones and their use as pharmaceuticals | FAB PHARMA S.A.S. (FR) | 2013-02-26 | — | — | US | disclosed |
| US-8268849-B2 | Multifunctional Antioxidants and methods of use thereof | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120232079-A1 | NOVEL ACYLPIPERAZINONES AND THEIR USE AS PHARMACEUTICALS | FAB PHARMA S.A.S. (FR) | 2012-09-13 | — | — | US | disclosed |
| EP-1762568-A1 | PYRAZOLE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-03-14 | — | — | EP | disclosed |
| EP-1423391-B1 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | NOVARTIS AG (CH) | 2006-05-17 | — | — | EP | disclosed |
| US-20050069276-A1 | Deuterated pyrazolopyrimidinones and drugs containing said compounds | BDD BEROLINA DRUG DEVELOPMENT GMBH (DE) | 2005-03-31 | — | — | US | disclosed |
| US-20050054851-A1 | Pyrrolo pyrimidines as agents for the inhibition of cystein proteases | NOVARTIS AG (CH) | 2005-03-10 | — | — | US | disclosed |
| EP-1444234-A2 | DEUTERATED PYRAZOLOPYRIMIDINONES AND DRUGS CONTAINING SAID COMPOUNDS | Turicum Drug Development AG (CH) | 2004-08-11 | — | — | EP | disclosed |
| EP-1423391-A1 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | Novartis AG (CH) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003039439-A2 | DEUTERATED PYRAZOLOPYRIMIDINONES AND DRUGS CONTAINING SAID COMPOUNDS | TURICUM DRUG DEVELOPMENT AG (CH) | 2003-05-15 | — | — | WO | disclosed |
| WO-2003020721-A1 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | NOVARTIS AG (CH) | 2003-03-13 | — | — | WO | disclosed |
| WO-2003020721-A1 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | NOVARTIS AG (CH) | 2003-03-13 | — | — | WO | disclosed |
| US-4820707-A | TREATING PSYCHOLOGICAL DISORDERS | ADIR ET CIE (FR) | 1989-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054851-A1 | Pyrrolo pyrimidines as agents for the inhibition of cystein proteases | CTSK, CTSS, CTSZ | EPHX2 1534/4885SIGMAR1 4770/4885GAA 344/4885 |
| US-20130137689-A1 | NOVEL ACYLPIPERAZINONES AND THEIR USE AS PHARMACEUTICALS | AGPAT5, GNPAT, AADAC | EPHX2 4046/4885SIGMAR1 1469/4885GAA 299/4885 |
| US-20120232079-A1 | NOVEL ACYLPIPERAZINONES AND THEIR USE AS PHARMACEUTICALS | AGPAT5, GNPAT, AADAC | EPHX2 4046/4885SIGMAR1 1469/4885GAA 299/4885 |
| US-20050069276-A1 | Deuterated pyrazolopyrimidinones and drugs containing said compounds | CHRM3, MPL, PFKP | EPHX2 1706/4885SIGMAR1 1140/4885GAA 3610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.