Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 2/20 | 0.59 |
| ▸ | NPC1L1 | Q9UHC9 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1526856 | 0.93 | BDKRB2 (0.56) | BDKRB2NPC1L1HSD17B10OPRM1OPRK1 | |
| SCHEMBL12893390 | 0.90 | BDKRB2 (0.74) | BDKRB2NPC1L1HSD17B10OPRM1OPRK1 | |
| SCHEMBL1640719 | 0.87 | OPRM1 (0.57) | BDKRB2NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL20187220 | 0.87 | OPRL1 (0.63) | BDKRB2NPC1L1HSD17B10OPRM1OPRK1 | |
| SCHEMBL1415422 | 0.86 | HSD17B10 (0.52) | BDKRB2NPC1L1HSD17B10OPRM1OPRK1 | |
| SCHEMBL20822346 | 0.86 | DDR1 (0.58) | BDKRB2NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL18972830 | 0.85 | BDKRB2 (0.55) | BDKRB2NPC1L1HSD17B10OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL20187149 | 0.85 | DDR1 (0.57) | BDKRB2NPC1L1OPRM1OPRK1OPRL1 | |
| SCHEMBL11876831 | 0.84 | OPRL1 (0.64) | BDKRB2NPC1L1HSD17B10OPRM1OPRK1 | |
| SCHEMBL20187099 | 0.84 | DDR1 (0.64) | BDKRB2NPC1L1DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486370-B2 | Heterocyclic ligands for integrin imaging and therapy | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-07-16 | — | — | US | claimed |
| US-8088890-B2 | Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition | FIBREX MEDICAL RESEARCH & DEVELOPMENT GMBH (AT) | 2012-01-03 | — | — | US | claimed |
| US-7922998-B2 | bombesin, derivatives and/or analogues capable of complexing metal ions, radionuclides or optical labels, for use in radiotherapy | BRACCO IMAGING S.P.A. (IT) | 2011-04-12 | — | — | US | claimed |
| EP-2281580-A2 | Labeled gastrin releasing peptides (GRP) | Bracco Imaging S.p.A (IT) | 2011-02-09 | — | — | EP | claimed |
| EP-2274328-A1 | PEPTIDES, PEPTIDOMIMETICS AND DERIVATIVES THEREOF, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION | Fibrex Medical Research & Development GmbH (AT) | 2011-01-19 | — | — | EP | claimed |
| US-7850947-B2 | Gastrin releasing peptide compounds | BRACCO IMAGING S.P.A. (IT) | 2010-12-14 | — | — | US | claimed |
| US-20100310455-A1 | Heterocyclic Ligands for Integrin Imaging and Therapy | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-12-09 | — | — | US | claimed |
| WO-2010043444-A2 | PHARMACEUTICAL PREPARATION FOR THE TREATMENT AND/OR PREVENTION OF ISCHEMIA/REPERFUSION INJURY AND THE SEQUELS THEREOF | FIBREX MEDICAL RESEARCH & DEVELOPMENT GMBH (AT) | 2010-04-22 | — | — | WO | claimed |
| US-20100081787-A1 | PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION | FIBREX MEDICAL RESEARCH & DEVELOPMENT GMBH (AT) | 2010-04-01 | — | — | US | claimed |
| WO-2009137850-A1 | PEPTIDES, PEPTIDOMIMETICS AND DERIVATIVES THEREOF, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION | FIBREX MEDICAL RESEARCH & DEVELOPMENT GMBH (AT) | 2009-11-19 | — | — | WO | claimed |
| US-7226577-B2 | Gastrin releasing peptide compounds | BRACCO IMAGING, S. P. A. (IT) | 2007-06-05 | — | — | US | claimed |
| WO-2007002500-A1 | GASTRIN RELEASING PEPTIDE COMPOUNDS | BRACCO IMAGING S.P.A. (IT) | 2007-01-04 | — | — | WO | claimed |
| US-20060239914-A1 | Gastrin releasing peptide compounds | BRACCO IMAGING S.P.A. (IT) | 2006-10-26 | — | — | US | claimed |
| US-20060239923-A1 | Gastrin releasing peptide compounds | BRACCO IMAGING S.P.A. (IT) | 2006-10-26 | — | — | US | claimed |
| WO-2005122379-A9 | ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY | UNIV CALIFORNIA (US) | 2006-03-09 | — | — | WO | claimed |
| US-20060019900-A1 | Alpha-4 beta-1 integrin ligands for imaging and therapy | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-01-26 | — | — | US | claimed |
| US-20060018830-A1 | Gastrin releasing peptide compounds | BRACCO IMAGING S.P.A. (IT) | 2006-01-26 | — | — | US | claimed |
| WO-2005122379-A2 | ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-12-22 | — | — | WO | claimed |
| US-20040253225-A1 | bombesin, derivatives and/or analogues capable of complexing metal ions, radionuclides or optical labels, for use in radiotherapy | BRACCO IMAGING S.P.A. (IT) | 2004-12-16 | — | — | US | claimed |
| US-20040136906-A1 | Gastrin releasing peptide compounds | BRACCO IMAGING S.P.A. (IT) | 2004-07-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100310455-A1 | Heterocyclic Ligands for Integrin Imaging and Therapy | ITGA1, ITGAL, ITGA4 | BDKRB2 420/4885NPC1L1 4328/4885HSD17B10 4762/4885 |
| US-20060239914-A1 | Gastrin releasing peptide compounds | GRPR, GIPR, CCKBR | BDKRB2 116/4885NPC1L1 2117/4885HSD17B10 4843/4885 |
| US-20040253225-A1 | bombesin, derivatives and/or analogues capable of complexing metal ions, radionuclides or optical labels, for use in radiotherapy | GRPR, MLNR, NPBWR1 | BDKRB2 170/4885NPC1L1 846/4885HSD17B10 4878/4885 |
| US-20060239923-A1 | Gastrin releasing peptide compounds | GRPR, GIPR, CCKBR | BDKRB2 253/4885NPC1L1 1555/4885HSD17B10 4866/4885 |
| US-20060018830-A1 | Gastrin releasing peptide compounds | GRPR, GIPR, CCKBR | BDKRB2 116/4885NPC1L1 2117/4885HSD17B10 4843/4885 |
| US-20060019900-A1 | Alpha-4 beta-1 integrin ligands for imaging and therapy | ITGA4, ITGB4, ITGA1 | BDKRB2 1027/4885NPC1L1 3993/4885HSD17B10 4810/4885 |
| US-20100081787-A1 | PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION | NGLY1, GHRHR, GHSR | BDKRB2 376/4885NPC1L1 4295/4885HSD17B10 955/4885 |
| US-20040136906-A1 | Gastrin releasing peptide compounds | GRPR, GIPR, MLNR | BDKRB2 757/4885NPC1L1 843/4885HSD17B10 4863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.