Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 7/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21849234 | 0.78 | ALDH1A1 (0.41) | GAAALDH1A1TDP1TSHRRBP4 | |
| SCHEMBL820508 | 0.77 | CYP3A4 (0.70) | GAAALDH1A1TDP1TSHRMAPK1 | |
| SCHEMBL28045541 | 0.75 | ALDH1A1 (0.44) | GAAKDM4EALDH1A1TDP1TSHR | |
| SCHEMBL2608425 | 0.75 | ALDH1A1 (0.38) | GAAKDM4EALDH1A1TDP1TSHR | |
| SCHEMBL19598923 | 0.75 | RXRA (0.35) | GAAKDM4EALDH1A1TSHRRBP4 | |
| SCHEMBL16188017 | 0.74 | ALDH1A1 (0.45) | GAAKDM4EALDH1A1MAPK1CA2 | |
| SCHEMBL28045653 | 0.74 | CA2 (0.46) | GAAKDM4EALDH1A1TDP1TSHR | |
| SCHEMBL12963296 | 0.73 | RBP4 (0.34) | ALDH1A1TDP1TSHRRBP4MAPK1 | |
| SCHEMBL26259525 | 0.71 | ALDH1A1 (0.34) | GAAKDM4EALDH1A1TDP1TSHR | |
| SCHEMBL26259918 | 0.71 | GRIA1 (0.36) | GAAKDM4EALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218711-B | A kind of double activated component olefin polymerization catalysis and preparation method | 淄博新塑化工有限公司 | 2017-08-25 | — | — | CN | claimed |
| CN-105218711-A | A kind of double activated component olefin polymerization catalysis and preparation method | ZIBO XINSU CHEMICAL CO LTD | 2016-01-06 | — | — | CN | claimed |
| EP-3344997-B1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | UNIV MINNESOTA (US) | 2020-11-18 | — | — | EP | disclosed |
| US-9827228-B2 | Opioid receptor modulators and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2017-11-28 | — | — | US | disclosed |
| CN-105218711-B | A kind of double activated component olefin polymerization catalysis and preparation method | 淄博新塑化工有限公司 | 2017-08-25 | — | — | CN | disclosed |
| US-20170056377-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-02 | — | — | US | disclosed |
| CN-105218711-A | A kind of double activated component olefin polymerization catalysis and preparation method | ZIBO XINSU CHEMICAL CO LTD | 2016-01-06 | — | — | CN | disclosed |
| US-8158825-B2 | Modified malonate derivatives | MERCK SHARP & DOHME CORP. (US) | 2012-04-17 | — | — | US | disclosed |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100160327-A1 | Modified Malonate Derivatives | MERCK SHARP & DOHME LLC | 2010-06-24 | — | — | US | disclosed |
| US-7709647-B2 | Tetrahydroquinoline cannabinoid receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-05-04 | — | — | US | disclosed |
| US-20080312435-A1 | Imine Compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-18 | — | — | US | disclosed |
| US-20080200459-A1 | TETRAHYDROQUINOLINE CANNABINOID RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2008-08-21 | — | — | US | disclosed |
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | ROSKAMP RESEARCH LLC (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | ROSKAMP RESEARCH LLC (US) | 2008-03-06 | — | — | US | disclosed |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-09 | — | — | US | disclosed |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ALZHEIMER'S INSTITUTE OF AMERICA, INC. | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312435-A1 | Imine Compound | CNR1, CNR2, HRH4 | GAA 4866/4885KDM4E 3386/4885ALDH1A1 2674/4885 |
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | APP, PSEN1, PSEN2 | GAA 489/4885KDM4E 4629/4885ALDH1A1 3749/4885 |
| US-20100160327-A1 | Modified Malonate Derivatives | ME2, ME3, ME1 | GAA 713/4885KDM4E 129/4885ALDH1A1 784/4885 |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | GAA 814/4885KDM4E 4759/4885ALDH1A1 3939/4885 |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | GAA 814/4885KDM4E 4759/4885ALDH1A1 3939/4885 |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | GAA 814/4885KDM4E 4759/4885ALDH1A1 3939/4885 |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | GAA 814/4885KDM4E 4759/4885ALDH1A1 3939/4885 |
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | GAA 814/4885KDM4E 4759/4885ALDH1A1 3939/4885 |
| US-20080200459-A1 | TETRAHYDROQUINOLINE CANNABINOID RECEPTOR MODULATORS | CNR1, CNR2, GPR18 | GAA 3880/4885KDM4E 2213/4885ALDH1A1 2247/4885 |
| US-20170056377-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | OPRM1, OPRK1, OPRL1 | GAA 3118/4885KDM4E 3397/4885ALDH1A1 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.