Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | KDM1A | O60341 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CDK9 | P50750 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1689206 | 0.90 | EPHX2 (0.68) | EPHX2L3MBTL1KDM1AMAPTHTT | |
| SCHEMBL9001575 | 0.89 | EPHX2 (0.57) | EPHX2L3MBTL1KDM1AMAPTHTT | |
| SCHEMBL70039 | 0.87 | ALDH1A1 (0.70) | MAPTHTTTP53SMN1; SMN2HDAC4 | |
| SCHEMBL27538195 | 0.86 | EPHX2 (0.63) | EPHX2L3MBTL1KDM1AMAPTHTT | |
| SCHEMBL9235727 | 0.84 | HDAC4 (0.61) | EPHX2L3MBTL1KDM1AMAPTHTT | |
| SCHEMBL3342586 | 0.83 | L3MBTL1 (0.80) | EPHX2L3MBTL1MAPTHTTSMN1; SMN2 | |
| SCHEMBL13476524 | 0.82 | MGLL (0.68) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL3021545 | 0.82 | MAPT (0.67) | EPHX2L3MBTL1KDM1AMAPTHTT | |
| SCHEMBL6832724 | 0.82 | CYP1A1 (0.71) | L3MBTL1MAPTTP53TSHRMAOB | |
| SCHEMBL14964154 | 0.82 | EPHX2 (0.59) | EPHX2L3MBTL1KDM1AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114044742-B | Chiral primary amine malonamide compound and preparation method and application thereof | 河北工业大学 | 2023-02-10 | — | — | CN | claimed |
| CN-114044742-A | Chiral primary amine malonamide compound and preparation method and application thereof | 河北工业大学 | 2022-02-15 | — | — | CN | claimed |
| US-10364208-B2 | Oxidative coupling of aryl boron reagents with SP3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2019-07-30 | — | — | US | claimed |
| US-20180186721-A1 | OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2018-07-05 | — | — | US | claimed |
| EP-0512211-B1 | Process for the preparation of substituted malonic ester anilides and malonic acid monoanilides | HUELS CHEMISCHE WERKE AG (DE) | 1995-04-12 | — | — | EP | claimed |
| US-5144077-A | PROCESS FOR WORKING UP THE CRYSTALLIZATION MOTHER LIQUOR FROM THE RESOLUTION OF THE RACEMATE OF 1-(4-CHLOROPHENYL)-ETHYLAMINE | BAYER AKTIENGESELLSCHAFT (DE) | 1992-09-01 | — | — | US | claimed |
| WO-1991015464-A1 | AMIDE ESTER ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1991-10-17 | — | — | WO | claimed |
| CN-115160204-B | Fibroblast activation protein inhibitor and preparation method and application thereof | 山东大学 | 2024-04-09 | — | — | CN | disclosed |
| CN-116969904-A | Compounds useful as autophagy modulators, methods of preparation and uses thereof | 微境生物医药科技(上海)有限公司 | 2023-10-31 | — | — | CN | disclosed |
| US-20230321130-A1 | Senolytic Compositions and Uses Thereof | Rubedo Life Sciences, Inc. | 2023-10-12 | — | — | US | disclosed |
| EP-3632903-B1 | COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF | WIGEN BIOMEDICINE TECH SHANGHAI CO LTD (CN) | 2023-10-11 | — | — | EP | disclosed |
| CN-111148740-B | Compounds useful as autophagy modulators, methods of preparation and uses thereof | 微境生物医药科技(上海)有限公司 | 2023-08-25 | — | — | CN | disclosed |
| US-11603349-B2 | Anti-fibrotic compounds | CERTA THERAPEUTICS PTY LTD (AU) | 2023-03-14 | — | — | US | disclosed |
| EP-0511003-A1 | Superactive GRF analogs | ELI LILLY AND COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| EP-0262209-B1 | SYNERGISTIC PLANT GROWTH REGULATOR COMPOSITIONS | RHONE POULENC BV (NL) | 1992-08-05 | — | — | EP | disclosed |
| US-5123951-A | Ethylene response inducing agent and malonic acid derivative | RHONE-POULENC NEDERLAND B.V. (NL) | 1992-06-23 | — | — | US | disclosed |
| US-4904787-A | CYCLIZATION USING POLYPHOSPHORIC ACID; NONHYDROLIZING, ONE STEP | MITSUBISHI KASEI CORPORATION (JP) | 1990-02-27 | — | — | US | disclosed |
| EP-0335046-A1 | Method for producing 2,4-dihydroxyquinoline derivatives | MITSUBISHI KASEI CORPORATION (JP) | 1989-10-04 | — | — | EP | disclosed |
| EP-0298040-A1 | 1,3-Dithiol-2-ylidene derivatives | YUHAN CORPORATION, LTD. (KR) | 1989-01-04 | — | — | EP | disclosed |
| EP-0101330-B1 | 2-QUINOLONE DERIVATIVES | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1988-08-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11603349-B2 | Anti-fibrotic compounds | TGFB1, SMAD3, TGFB2 | EPHX2 2366/4885L3MBTL1 4340/4885KDM1A 3973/4885 |
| US-10364208-B2 | Oxidative coupling of aryl boron reagents with SP3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis | SOD1, AOC3, CBR3 | EPHX2 2857/4885L3MBTL1 2188/4885KDM1A 4041/4885 |
| US-20230321130-A1 | Senolytic Compositions and Uses Thereof | SENP3, SENP6, SENP1 | EPHX2 3688/4885L3MBTL1 1107/4885KDM1A 2701/4885 |
| US-20180186721-A1 | OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS | SOD1, AOC3, CBR3 | EPHX2 2857/4885L3MBTL1 2188/4885KDM1A 4041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.