SCHEMBL175932

SCHEMBL175932

O=C(O)c1cc(S)ccn1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.61
ALDH1A1 P00352 5/20 0.61
KDM5A P29375 2/20 0.61
KDM3A Q9Y4C1 2/20 0.61
ASPH Q12797 2/20 0.61
KDM8 Q8N371 2/20 0.61
KDM6B O15054 1/20 0.61
TET3 O43151 1/20 0.61
KDM4A O75164 1/20 0.61
BBOX1 O75936 1/20 0.61
MAPT P10636 1/20 0.61
KDM5C P41229 1/20 0.61
KDM4D Q6B0I6 1/20 0.61
TET2 Q6N021 1/20 0.61
ALKBH5 Q6P6C2 1/20 0.61
KDM7A Q6ZMT4 1/20 0.61
TET1 Q8NFU7 1/20 0.61
EGLN2 Q96KS0 1/20 0.61
FTO Q9C0B1 1/20 0.61
EGLN1 Q9GZT9 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2643688 0.83 ALDH1A1 (0.52) KDM4EALDH1A1KDM5AKDM3AASPH
SCHEMBL2644298 0.81 ADORA3 (0.45) KDM4EALDH1A1KDM5AKDM3AASPH
SCHEMBL30800092 0.79 KMO (0.71) KDM4EALDH1A1KDM5AKDM3AASPH
SCHEMBL7513922 0.79 KMO (0.71) KDM4EALDH1A1KDM5AKDM3AASPH
SCHEMBL31368469 0.76 ALDH1A1 (0.50) KDM4EALDH1A1KDM3AKDM6BMAPT
SCHEMBL2064847 0.76 ALDH1A1 (0.50) KDM4EALDH1A1KDM3AKDM6BMAPT
SCHEMBL2642557 0.76 KDR (0.46) KDM4EALDH1A1MAPTKDM4CLMNA
SCHEMBL2642934 0.76 ALDH1A1 (0.40) KDM4EALDH1A1KDM5AKDM3AASPH
SCHEMBL72377 0.76 KDM5C (1.00) KDM4EALDH1A1KDM5AKDM3AASPH
SCHEMBL29382783 0.76 KDM5C (1.00) KDM4EALDH1A1KDM5AKDM3AASPH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2195329-B1 METHOD FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS IPSEN PHARMA SAS (FR) 2013-11-06 EP claimed
US-8404804-B2 Methods and intermediates for chemical synthesis of polypeptides and proteins IPSEN PHARMA S.A.S. (FR) 2013-03-26 US claimed
US-20100234564-A1 METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS IPSEN PHARMA S.A.S. (FR) 2010-09-16 US claimed
US-20100204449-A1 METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS IPSEN PHARMA S.A.S. (FR) 2010-08-12 US claimed
EP-2197895-A2 METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS IPSEN PHARMA S.A.S. (FR) 2010-06-23 EP claimed
EP-2195329-A2 METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS IPSEN PHARMA S.A.S. (FR) 2010-06-16 EP claimed
WO-2009032181-A2 METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS IPSEN PHARMA S.A.S. (FR) 2009-03-12 WO claimed
WO-2009032133-A2 METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS IPSEN PHARMA S.A.S. (FR) 2009-03-12 WO claimed
EP-0832096-B1 SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION SCRIPPS RESEARCH INST (US) 2001-07-18 EP claimed
US-6184344-B1 Synthesis of proteins by native chemical ligation THE SCRIPPS RESEARCH INSTITUTE 2001-02-06 US claimed
EP-0832096-A4 SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION SCRIPPS RESEARCH INST (US) 1998-08-05 EP claimed
EP-0832096-A1 SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION The Scripps Research Institute (US) 1998-04-01 EP claimed
WO-1996034878-A1 SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION THE SCRIPPS RESEARCH INSTITUTE (US) 1996-11-07 WO claimed
WO-2022272060-A1 EP2 ANTAGONIST COMPOUNDS RESERVOIR NEUROSCIENCE, INC. (US) 2022-12-29 WO disclosed
US-11022880-B2 Chemically amplified positive-type photosensitive resin composition, photosensitive dry film, method of manufacturing photosensitive dry film, method of manufacturing patterned resist film, method of manufacturing substrate with template, method of manufacturing plated article, and mercapto compound TOKYO OHKA KOGYO CO., LTD. (JP) 2021-06-01 US disclosed
US-20190121233-A1 CHEMICALLY AMPLIFIED POSITIVE-TYPE PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE DRY FILM, METHOD OF MANUFACTURING PHOTOSENSITIVE DRY FILM, METHOD OF MANUFACTURING PATTERNED RESIST FILM, METHOD OF MANUFACTURING SUBSTRATE WITH TEMPLATE, METHOD OF MANUFACTURING PLATED ARTICLE, AND MERCAPTO COMPOUND TOKYO OHKA KOGYO CO., LTD. (JP) 2019-04-25 US disclosed
US-4576973-A ADSORBENT BEAD CASSELLA AKTIENGESELLSCHAFT (DE) 1986-03-18 US disclosed
US-4552905-A VINYL-SUBSTITUTED PYRIDINE, QUINOLINE, ISO-QUINOLINE, OR PYRAZINE;N-VINYLAMIDE, CROSSLINKER CASSELLA AKTIENGESELLSCHAFT (DE) 1985-11-12 US disclosed
EP-0134921-A1 Copolymer, process for its preparation and its use as a sorbent CASSELLA Aktiengesellschaft (DE) 1985-03-27 EP disclosed
EP-0131179-A1 Copolymer, process for its preparation and its use as a sorbent CASSELLA Aktiengesellschaft (DE) 1985-01-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190121233-A1 CHEMICALLY AMPLIFIED POSITIVE-TYPE PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE DRY FILM, METHOD OF MANUFACTURING PHOTOSENSITIVE DRY FILM, METHOD OF MANUFACTURING PATTERNED RESIST FILM, METHOD OF MANUFACTURING SUBSTRATE WITH TEMPLATE, METHOD OF MANUFACTURING PLATED ARTICLE, AND MERCAPTO COMPOUND CUTA, POLR1C, ASIC1 KDM4E 2101/4885ALDH1A1 639/4885KDM5A 966/4885
US-11022880-B2 Chemically amplified positive-type photosensitive resin composition, photosensitive dry film, method of manufacturing photosensitive dry film, method of manufacturing patterned resist film, method of manufacturing substrate with template, method of manufacturing plated article, and mercapto compound CUTA, POLR1C, ASIC1 KDM4E 2101/4885ALDH1A1 639/4885KDM5A 966/4885
US-20100204449-A1 METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS PTMS, TMT1A, MTR KDM4E 772/4885ALDH1A1 2619/4885KDM5A 508/4885
US-20100234564-A1 METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS PTMS, RNGTT, MTR KDM4E 1052/4885ALDH1A1 3245/4885KDM5A 669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.