Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 14/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18114045 | 0.88 | ELANE (0.35) | ELANEMAPTLMNAALDH1A1CYP2C9 | |
| SCHEMBL18114101 | 0.86 | ELANE (0.44) | ELANEMAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL18121451 | 0.85 | ELANE (0.40) | ELANEMAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL18114065 | 0.84 | ELANE (0.38) | ELANEMAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL20110944 | 0.83 | ELANE (0.43) | ELANEMAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL18114031 | 0.82 | POLB (0.32) | LMNA | |
| SCHEMBL18114060 | 0.81 | ELANE (0.41) | ELANEMAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL18114100 | 0.80 | ELANE (0.40) | ELANEMAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL25654130 | 0.78 | ELANE (0.40) | ELANEMAPTLMNANPSR1ALDH1A1 | |
| Thiosulfuric Acid SCHEMBL28604410 | 0.77 | ELANE (0.37) | ELANEMAPTLMNANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277662-B1 | HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF | UNIV GEORGIA STATE RES FOUND (US) | 2025-01-22 | — | — | EP | disclosed |
| US-10689335-B2 | Hydrogen sulfide precursors and conjugates thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2020-06-23 | — | — | US | disclosed |
| US-20180118674-A1 | HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC (US) | 2018-05-03 | — | — | US | disclosed |
| EP-3277662-A1 | HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF | Georgia State University Research Foundation (US) | 2018-02-07 | — | — | EP | disclosed |
| WO-2016161445-A1 | HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2016-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689335-B2 | Hydrogen sulfide precursors and conjugates thereof | CBS, TST, STS | ELANE 559/4885MAPT 4618/4885LMNA 4368/4885 |
| US-20180118674-A1 | HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF | CBS, TST, STS | ELANE 559/4885MAPT 4618/4885LMNA 4368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.