Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.76 |
| ▸ | SGMS1 | Q86VZ5 | 4/20 | 0.76 |
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.76 |
| ▸ | SLC5A1 | P13866 | 8/20 | 0.74 |
| ▸ | SLC5A2 | P31639 | 7/20 | 0.74 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.74 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.74 |
| ▸ | RELA | Q04206 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | ATM | Q13315 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | TTR | P02766 | 1/20 | 0.74 |
| ▸ | ESR1 | P03372 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24842064 | 0.87 | ACHE (0.75) | ACHESGMS1SGMS2SLC5A1SLC5A2 | |
| Malabaricone B SCHEMBL30291815 | 0.86 | ACHE (1.00) | ACHESGMS1SGMS2SLC5A1SLC5A2 | |
| Phloretin SCHEMBL21192491 | 0.86 | SLC5A1 (0.87) | ACHESGMS1SGMS2SLC5A1SLC5A2 | |
| Phloretin SCHEMBL38131 | 0.85 | SLC5A1 (1.00) | ACHESGMS1SGMS2SLC5A1SLC5A2 | |
| Phloretin SCHEMBL1506325 | 0.85 | SLC5A1 (1.00) | ACHESGMS1SGMS2SLC5A1SLC5A2 | |
| SCHEMBL6397026 | 0.85 | ACHE (0.57) | ACHESGMS1SGMS2SLC5A1SLC5A2 | |
| Phloretin SCHEMBL31684375 | 0.84 | SLC5A1 (0.96) | ACHESGMS1SGMS2SLC5A1SLC5A2 | |
| Phloretin SCHEMBL30912872 | 0.84 | SLC5A1 (0.96) | ACHESGMS1SGMS2SLC5A1SLC5A2 | |
| Phloretin SCHEMBL30785809 | 0.84 | SLC5A1 (0.96) | ACHESGMS1SGMS2SLC5A1SLC5A2 | |
| SCHEMBL8115827 | 0.83 | NFKB1 (0.77) | ACHESGMS1SGMS2SLC5A1SLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1972203-B1 | Use of 4-hydroxychalkon derivatives for masking an unpleasant taste | SYMRISE AG (DE) | 2012-05-16 | — | — | EP | claimed |
| EP-1977655-B1 | Aroma compositions of alkamides with hesperetin and/or 4-hydroxydihydrochalkones and their salts for reinforcing sweet sensory impressions | SYMRISE AG (DE) | 2011-05-18 | — | — | EP | claimed |
| US-20100233102-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2010-09-16 | — | — | US | claimed |
| EP-1998636-B1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO KG (DE) | 2010-05-19 | — | — | EP | claimed |
| EP-1998636-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | Symrise GmbH & Co. KG (DE) | 2008-12-10 | — | — | EP | claimed |
| EP-1977655-A1 | Aroma compositions of alkamides with hesperetin and/or 4-hydroxydihydrochalkones and their salts for reinforcing sweet sensory impressions | Symrise GmbH & Co. KG (DE) | 2008-10-08 | — | — | EP | claimed |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | SYMRISE GMBH & CO. KG (DE) | 2008-10-02 | — | — | US | claimed |
| EP-1972203-A1 | Use of 4-hydroxychalkon derivatives for masking an unpleasant taste | Symrise GmbH & Co. KG (DE) | 2008-09-24 | — | — | EP | claimed |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | claimed |
| WO-2007107596-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2007-09-27 | — | — | WO | claimed |
| US-20260114475-A1 | ANIMAL FOOD COMPOSITIONS WITH IMPROVED PALATABILITY AND CUSTOMIZABILITY, AND METHODS FOR PREPARING THE SAME | MARS, INCORPORATED (US) | 2026-04-30 | — | — | US | disclosed |
| EP-4593631-A1 | ANIMAL FOOD COMPOSITIONS WITH IMPROVED PALATABILITY AND CUSTOMIZABILITY, AND METHODS FOR PREPARING THE SAME | Mars, Incorporated (US) | 2025-08-06 | — | — | EP | disclosed |
| CN-119968127-A | Animal food compositions with improved palatability and customizable properties and methods of making the same | 玛氏公司 | 2025-05-09 | — | — | CN | disclosed |
| US-20250084049-A1 | POLYCATIONIC SALTS OF PHENOLIC COMPOUNDS AND USES THEREOF | FIRMENICH INCORPORATED (US) | 2025-03-13 | — | — | US | disclosed |
| WO-2024073025-A1 | ANIMAL FOOD COMPOSITIONS WITH IMPROVED PALATABILITY AND CUSTOMIZABILITY, AND METHODS FOR PREPARING THE SAME | MARS, INCORPORATED (US) | 2024-04-04 | — | — | WO | disclosed |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| WO-2007107596-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2007-09-27 | — | — | WO | disclosed |
| WO-2007107596-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2007-09-27 | — | — | WO | disclosed |
| US-5731292-A | ANTIDIABETIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1998-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250084049-A1 | POLYCATIONIC SALTS OF PHENOLIC COMPOUNDS AND USES THEREOF | PGC, SLC5A6, PUF60 | ACHE 4358/4885SGMS1 927/4885SGMS2 691/4885 |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | TAS2R45, TAS2R43, TAS2R30 | ACHE 79/4885SGMS1 373/4885SGMS2 458/4885 |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | TAS2R5, TAS2R20, TAS2R40 | ACHE 720/4885SGMS1 1586/4885SGMS2 1202/4885 |
| US-20260114475-A1 | ANIMAL FOOD COMPOSITIONS WITH IMPROVED PALATABILITY AND CUSTOMIZABILITY, AND METHODS FOR PREPARING THE SAME | PIGS, TAS2R13, CEL | ACHE 3373/4885SGMS1 1768/4885SGMS2 1132/4885 |
| US-20100233102-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | TAS2R4, TAS2R1, TAS2R20 | ACHE 3667/4885SGMS1 777/4885SGMS2 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.