Sugi Predict

Sugi Predict / Compounds / SCHEMBL1859617

SCHEMBL1859617

SCHEMBL1859617

COc1cccc2occc(=O)c12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 3/20 0.59
▸ ALDH1A1 P00352 5/20 0.57
▸ HPGD P15428 4/20 0.57
▸ KDM4E B2RXH2 3/20 0.57
▸ LMNA P02545 3/20 0.57
▸ SMN1; SMN2 Q16637 2/20 0.57
▸ NPC1 O15118 1/20 0.57
▸ RAB9A P51151 1/20 0.57
▸ TDP1 Q9NUW8 1/20 0.57
▸ MEN1 O00255 6/20 0.56
▸ KMT2A Q03164 6/20 0.56
▸ MAOA P21397 4/20 0.55
▸ MAPT P10636 5/20 0.54
▸ GAA P10253 1/20 0.53
▸ CYP3A4 P08684 3/20 0.53
▸ AR P10275 2/20 0.53
▸ TP53 P04637 2/20 0.53
▸ HSD17B10 Q99714 2/20 0.53
▸ CYP2C9 P11712 2/20 0.49
▸ CYP2C19 P33261 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29959798 1.00 MAOB (0.59) MAOBALDH1A1HPGDKDM4ELMNA
SCHEMBL3843389 0.78 HDAC4 (0.51) MAOBALDH1A1HPGDKDM4ELMNA
SCHEMBL1472177 0.76 KDM4E (0.57) ALDH1A1HPGDKDM4ELMNASMN1; SMN2
SCHEMBL10517239 0.76 MAOB (0.63) MAOBALDH1A1HPGDKDM4ELMNA
SCHEMBL27746734 0.76 MAOB (0.63) MAOBALDH1A1HPGDKDM4ELMNA
SCHEMBL11655753 0.76 MAOB (0.59) MAOBALDH1A1HPGDKDM4ELMNA
SCHEMBL29568413 0.76 MAOB (0.48) MAOBALDH1A1HPGDKDM4ELMNA
SCHEMBL546446 0.76 MAOB (0.48) MAOBALDH1A1HPGDKDM4ELMNA
SCHEMBL17237767 0.74 ABCB1 (0.53) ALDH1A1HPGDKDM4ESMN1; SMN2NPC1
SCHEMBL9976085 0.74 ALDH1A1 (0.65) ALDH1A1HPGDKDM4ELMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12138232-B2 Compounds for treating coronavirus infection NLC PHARMA LTD (IL) 2024-11-12 — — US disclosed
US-20240130983-A1 COMPOUNDS FOR TREATING CORONAVIRUS INFECTION NLC PHARMA LTD (IL) 2024-04-25 — — US disclosed
US-11857517-B2 Compounds for treating corona virus infection NLC PHARMA LTD (IL) 2024-01-02 — — US disclosed
CN-115916172-A Compounds for treating coronavirus infections NLC制药有限公司 2023-04-04 — — CN disclosed
EP-4103164-A1 COMPOUNDS FOR TREATING CORONAVIRUS INFECTION NLC Pharma Ltd (IL) 2022-12-21 — — EP disclosed
US-20220387354-A1 COMPOUNDS FOR TREATING CORONAVIRUS INFECTION NLC PHARMA LTD (IL) 2022-12-08 — — US disclosed
WO-2022036040-A1 SYNTHESIS OF SMALL MOLECULES INSPIRED BY PHOMOXANTHONE A WORCESTER POLYTECHNIC INSTITUTE (US) 2022-02-17 — — WO disclosed
US-20220048879-A1 Synthesis of small molecules inspired by Phomoxanthone A WORCESTER POLYTECHNIC INSTITUTE 2022-02-17 — — US disclosed
CN-111848451-B Preparation method of cyano compound 中国科学院化学研究所 2021-08-24 — — CN disclosed
WO-2021161283-A1 COMPOUNDS FOR TREATING CORONAVIRUS INFECTION NLC PHARMA LTD (IL) 2021-08-19 — — WO disclosed
EP-1856084-A1 CHROMEN-4-ONE DERIVATIVES Merck Patent GmbH (DE) 2007-11-21 — — EP disclosed
US-20070191305-A1 Chromone complexes MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2007-08-16 — — US disclosed
WO-2007087956-A1 CHROMEN-4-ONE DERIVATIVES AS A SELF-TANNING SUBSTANCE MERCK PATENT GMBH (DE) 2007-08-09 — — WO disclosed
US-20060292093-A1 Chromen-4-one derivatives MERCK PATENT GMBH (DE) 2006-12-28 — — US disclosed
EP-1732913-A1 CHROMONE COMPLEXES MERCK PATENT GmbH (DE) 2006-12-20 — — EP disclosed
WO-2006128562-A1 USE OF CHROMONE DERIVATIVES MERCK PATENT GMBH (DE) 2006-12-07 — — WO disclosed
WO-2006094601-A1 CHROMEN-4-ONE DERIVATIVES MERCK PATENT GMBH (DE) 2006-09-14 — — WO disclosed
WO-2005097772-A1 CHROMONE COMPLEXES MERCK PATENT GMBH (DE) 2005-10-20 — — WO disclosed
US-20050043398-A1 Use of chromen-4-one derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 2005-02-24 — — US disclosed
EP-1508327-A1 Use of chromen-4-one derivatives for the care of skin and hair MERCK PATENT GmbH (DE) 2005-02-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240130983-A1 COMPOUNDS FOR TREATING CORONAVIRUS INFECTION SARS1, BECN1, PRSS1 MAOB 2540/4885ALDH1A1 3670/4885HPGD 3254/4885
US-11857517-B2 Compounds for treating corona virus infection SARS1, CTSA, CTSV MAOB 1796/4885ALDH1A1 3254/4885HPGD 4150/4885
US-20070191305-A1 Chromone complexes SCO2, CDYL, CYCS MAOB 1682/4885ALDH1A1 2949/4885HPGD 2181/4885
US-20220387354-A1 COMPOUNDS FOR TREATING CORONAVIRUS INFECTION SARS1, BECN1, PRSS1 MAOB 2540/4885ALDH1A1 3670/4885HPGD 3254/4885
US-12138232-B2 Compounds for treating coronavirus infection SARS1, BECN1, PRSS1 MAOB 2540/4885ALDH1A1 3670/4885HPGD 3254/4885
US-20050043398-A1 Use of chromen-4-one derivatives CYP8B1, CYP7B1, CYP2R1 MAOB 796/4885ALDH1A1 226/4885HPGD 1906/4885
US-20220048879-A1 Synthesis of small molecules inspired by Phomoxanthone A ERG28, SQLE, PHKA1 MAOB 674/4885ALDH1A1 2695/4885HPGD 2703/4885
US-20060292093-A1 Chromen-4-one derivatives TYR, XPA, CYP19A1 MAOB 203/4885ALDH1A1 55/4885HPGD 291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.