SCHEMBL18663404

SCHEMBL18663404

COC(=O)C1(C(=O)OC)C(c2ccccc2)=C(c2ccc(C(C)=O)cc2)c2ccccc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ LMNA P02545 2/20 0.39
▸ FGFR1 P11362 1/20 0.37
▸ SRC P12931 1/20 0.37
▸ FGFR2 P21802 1/20 0.37
▸ FGFR4 P22455 1/20 0.37
▸ FGFR3 P22607 1/20 0.37
▸ HSP90AA1 P07900 4/20 0.37
▸ HSP90AB1 P08238 4/20 0.37
▸ THRB P10828 1/20 0.36
▸ EGFR P00533 1/20 0.36
▸ SGK1 O00141 1/20 0.36
▸ NPC1 O15118 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ TAAR1 Q96RJ0 1/20 0.35
▸ PDK2 Q15119 2/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ SCN1A P35498 1/20 0.34
▸ SCN2A Q99250 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18663367 0.87 FGFR1 (0.39) MAPTSMN1; SMN2LMNAFGFR1SRC
SCHEMBL19690413 0.87 SMN1; SMN2 (0.43) MAPTSMN1; SMN2LMNANPC1RAB9A
SCHEMBL19690698 0.84 GAA (0.38) SMN1; SMN2LMNAFGFR1SRCFGFR2
SCHEMBL18663292 0.83 BACE1 (0.43) MAPTFGFR1SRCFGFR2FGFR4
SCHEMBL18663282 0.81 PTGS2 (0.36) MAPTSMN1; SMN2HSP90AA1HSP90AB1PDK2
SCHEMBL19690521 0.80 SMN1; SMN2 (0.44) MAPTSMN1; SMN2FGFR1SRCFGFR2
SCHEMBL18663293 0.79 SLC6A3 (0.45) MAPTLMNAFGFR1SRCFGFR2
SCHEMBL18663374 0.77 OPRK1 (0.39) MAPTLMNAFGFR1SRCFGFR2
SCHEMBL27958006 0.77 MAPT (0.49) MAPTSMN1; SMN2LMNAHSP90AA1HSP90AB1
SCHEMBL19690532 0.77 ALDH1A1 (0.39) MAPTSMN1; SMN2LMNAPDK2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170088642-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST CONTAINING CATALYST COMPONENT AND USE THEREOF BEIJING LIHE TECH LTD (CN) 2017-03-30 — — US claimed
US-20190169328-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF RENQIU LIHE TECH LTD (CN) 2019-06-06 — — US disclosed
US-20170355792-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF RENQIU LIHE TECH LTD (CN) 2017-12-14 — — US disclosed
US-20170088642-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST CONTAINING CATALYST COMPONENT AND USE THEREOF BEIJING LIHE TECH LTD (CN) 2017-03-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170088642-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST CONTAINING CATALYST COMPONENT AND USE THEREOF TEC, DGAT2, MOGAT2 MAPT 2368/4885SMN1; SMN2 4599/4885LMNA 4300/4885
US-20190169328-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF COG2, GTF2I, POF1B MAPT 2703/4885SMN1; SMN2 1503/4885LMNA 2302/4885
US-20170355792-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF COG2, COG7, COG4 MAPT 3639/4885SMN1; SMN2 3127/4885LMNA 3701/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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