Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ALPI | P09923 | 3/20 | 0.31 |
| ▸ | ALPL | P05186 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28237878 | 0.82 | PTGS2 (0.34) | LMNAPTGS1PTGS2TP53L3MBTL1 | |
| SCHEMBL18718169 | 0.77 | GAA (0.32) | ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL31532384 | 0.76 | LMNA (0.40) | LMNAPTGS1PTGS2ALDH1A1ALPI | |
| SCHEMBL2523217 | 0.73 | RAB9A (0.39) | LMNAPTGS1PTGS2ALDH1A1KDM4E | |
| SCHEMBL18695205 | 0.72 | TP53 (0.41) | LMNAPTGS1PTGS2ALDH1A1HPGD | |
| SCHEMBL27783208 | 0.71 | LMNA (0.40) | LMNAALPIALPLTP53L3MBTL1 | |
| SCHEMBL18695253 | 0.70 | TP53 (0.45) | LMNAALDH1A1HPGDTP53L3MBTL1 | |
| SCHEMBL25212516 | 0.69 | TGFBR1 (0.33) | LMNAPTGS1PTGS2KDM4E | |
| SCHEMBL18695186 | 0.68 | L3MBTL1 (0.43) | LMNAALDH1A1HPGDTP53L3MBTL1 | |
| SCHEMBL4559955 | 0.65 | CRHR1 (0.41) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | TRPV1, CACNA1G, CACNA1B | LMNA 2317/4885PTGS1 264/4885PTGS2 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.