Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | POLA1 | P09884 | 1/20 | 0.35 |
| ▸ | POLD1 | P28340 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187972 | 0.92 | TK1 (0.50) | TK1POLBPOLA1POLD1 | |
| SCHEMBL186844 | 0.91 | TK1 (0.51) | TK1POLBPOLA1POLD1 | |
| SCHEMBL187924 | 0.87 | TK1 (0.41) | TK1POLBPOLA1POLD1 | |
| SCHEMBL187829 | 0.82 | TK1 (0.62) | TK1POLBPOLA1POLD1 | |
| SCHEMBL187841 | 0.78 | TK1 (0.50) | TK1POLB | |
| SCHEMBL8815106 | 0.77 | POLB (0.60) | TK1POLBPOLA1POLD1 | |
| SCHEMBL9084280 | 0.75 | TK1 (0.46) | TK1 | |
| Phosphoric Acid SCHEMBL1445017 | 0.74 | TK1 (0.53) | TK1 | |
| SCHEMBL9083809 | 0.74 | POLA1 (0.50) | TK1POLBPOLA1POLD1 | |
| SCHEMBL2056628 | 0.73 | LMNA (0.51) | TK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402357-B1 | Analogs of 2',3'-dideoxy-3'-fluorothymidine 5'-monophosphate (FLTMP) for use in the treatment of infections caused by human HIV-1 strains | INST BIOCHEMII I BIOFIZYKI PAN (PL) | 2015-10-14 | — | — | EP | disclosed |
| EP-2402357-A1 | Analogs of 2',3'-dideoxy-3'-fluorothymidine 5'-monophosphate (FLTMP) for treatment human immunodeficiency virus (HIV), their application and pharmaceutically acceptable form of drug | Instytut Biochemii I Biofizyki Pan (PL) | 2012-01-04 | — | — | EP | disclosed |