Sugi Predict

Sugi Predict / Compounds / SCHEMBL188089

SCHEMBL188089

SCHEMBL188089

N[C@@H](Cc1cccc(F)c1F)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOS3 P29474 3/20 0.50
▸ NOS1 P29475 3/20 0.50
▸ NOS2 P35228 3/20 0.50
▸ USP2 O75604 2/20 0.50
▸ PKM P14618 2/20 0.50
▸ HIF1A Q16665 2/20 0.50
▸ KDM4E B2RXH2 2/20 0.50
▸ MEN1 O00255 2/20 0.50
▸ LMNA P02545 2/20 0.50
▸ MAPT P10636 2/20 0.50
▸ BLM P54132 2/20 0.50
▸ PMP22 Q01453 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ SLC7A5 Q01650 2/20 0.50
▸ RGS12 O14924 1/20 0.50
▸ CYP3A4 P08684 1/20 0.50
▸ CYP2C9 P11712 1/20 0.50
▸ ALOX15 P16050 1/20 0.50
▸ NFKB1 P19838 1/20 0.50
▸ CASP1 P29466 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL188088 1.00 NOS3 (0.50) NOS3NOS1NOS2USP2PKM
SCHEMBL21690071 1.00 NOS3 (0.50) NOS3NOS1NOS2USP2PKM
SCHEMBL29430356 1.00 NOS3 (0.50) NOS3NOS1NOS2USP2PKM
SCHEMBL6530512 0.86 PTPN1 (0.48) NOS3NOS1NOS2USP2PKM
SCHEMBL29401250 0.86 PKM (0.58) NOS3NOS1NOS2USP2PKM
SCHEMBL268942 0.86 PKM (0.58) NOS3NOS1NOS2USP2PKM
SCHEMBL44126 0.86 PKM (0.58) NOS3NOS1NOS2USP2PKM
SCHEMBL44127 0.86 PKM (0.58) NOS3NOS1NOS2USP2PKM
SCHEMBL27125031 0.85 KDM4E (0.57) NOS3NOS1NOS2USP2PKM
SCHEMBL9952323 0.85 KDM4E (0.57) NOS3NOS1NOS2USP2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230303647-A1 CYCLIC CHEMERIN-9 DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2023-09-28 — — US claimed
CN-116390742-A Cyclic chemokine-9 derivatives 拜耳公司 2023-07-04 — — CN claimed
EP-4196143-A1 CYCLIC CHEMERIN-9 DERIVATIVES Bayer Aktiengesellschaft (DE) 2023-06-21 — — EP claimed
US-11274126-B2 pH-sensitive cyclic peptides UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES (US) 2022-03-15 — — US claimed
WO-2022034057-A1 CYCLIC CHEMERIN-9 DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2022-02-17 — — WO claimed
EP-3432908-A1 pH-SENSITIVE PEPTIDES Rhode Island Council on Postsecondary Education (US) 2019-01-30 — — EP claimed
WO-2017165452-A1 pH-SENSITIVE PEPTIDES RHODE ISLAND COUNCIL ON POSTSECONDARY EDUCATION (US) 2017-09-28 — — WO claimed
EP-4687443-A1 METHOD FOR FUNCTIONALISING A SOLID SUBSTRATE WITH A PEPTIDE CONJUGATE Genepep (FR) 2026-02-11 — — EP disclosed
EP-3966226-B1 MASP INHIBITORY COMPOUNDS AND USES THEREOF BAYER AG (DE) 2025-12-24 — — EP disclosed
US-12503491-B2 MASP inhibitory compounds and uses thereof BAYER AKTIENGESELLSCHAFT (DE) 2025-12-23 — — US disclosed
EP-3303367-B1 STABILIZED MINIMAL COILED-COIL MIMETICS UNIV NEW YORK (US) 2025-06-18 — — EP disclosed
US-12290575-B2 Fluorescent compound comprising a fluorophore conjugated to a pH-triggered polypeptide UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES (US) 2025-05-06 — — US disclosed
WO-2024208878-A1 METHOD FOR FUNCTIONALISING A SOLID SUBSTRATE WITH A PEPTIDE CONJUGATE GENEPEP (FR) 2024-10-10 — — WO disclosed
US-20080249030-A1 Age Inhibitors CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2008-10-09 — — US disclosed
EP-1863832-A1 AGE INHIBITORS Pharmamens (FR) 2007-12-12 — — EP disclosed
WO-2006103274-A9 AGE INHIBITORS PHARMAMENS (FR) 2007-01-18 — — WO disclosed
WO-2006103274-A1 AGE INHIBITORS PHARMAMENS (FR) 2006-10-05 — — WO disclosed
EP-1603926-A1 PHOSPHATE/SULFATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN INTERACTING NIMA (PIN1) PFIZER INC. (US) 2005-12-14 — — EP disclosed
US-20050250742-A1 Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1) PFIZER INC. 2005-11-10 — — US disclosed
WO-2004087720-A1 PHOSPHATE/SULFATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN INTERACTING NIMA (PIN1) PFIZER INC. (US) 2004-10-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11274126-B2 pH-sensitive cyclic peptides VIP, PHLPP1, PHLPP2 NOS3 2795/4885NOS1 3093/4885NOS2 2794/4885
US-20050250742-A1 Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1) PIN1, PSTPIP2, NIM1K NOS3 1732/4885NOS1 1758/4885NOS2 1831/4885
US-12503491-B2 MASP inhibitory compounds and uses thereof MASP2, SERPINB1, SPINT2 NOS3 1108/4885NOS1 1182/4885NOS2 1395/4885
US-20230303647-A1 CYCLIC CHEMERIN-9 DERIVATIVES CMKLR1, CMKLR2, CCL2 NOS3 376/4885NOS1 462/4885NOS2 391/4885
US-12290575-B2 Fluorescent compound comprising a fluorophore conjugated to a pH-triggered polypeptide NPPA, LNPEP, VIP NOS3 2720/4885NOS1 2770/4885NOS2 2632/4885
US-20080249030-A1 Age Inhibitors CFH, XPA, XPNPEP1 NOS3 848/4885NOS1 1035/4885NOS2 3081/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.