SCHEMBL189858

SCHEMBL189858

Nn1[nH]c(=O)c2ccccc2c1=O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.59
TP53 P04637 1/20 0.59
TSHR P16473 1/20 0.57
GAA P10253 2/20 0.49
MAPK1 P28482 2/20 0.49
GLS O94925 1/20 0.49
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
POLB P06746 1/20 0.45
PLEC Q15149 1/20 0.45
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
ALDH1A1 P00352 3/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 1/20 0.41
HPGD P15428 1/20 0.41
CYP2C19 P33261 1/20 0.41
ALOX5 P09917 1/20 0.39
PARP1 P09874 2/20 0.39
TNKS O95271 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29930611 1.00 KDM4E (0.59) KDM4ETP53TSHRGAAMAPK1
SCHEMBL1316368 0.98 KDM4E (0.57) KDM4ETP53TSHRGAAMAPK1
SCHEMBL1316369 0.98 KDM4E (0.57) KDM4ETP53TSHRGAAMAPK1
SCHEMBL16474145 0.78 ALOX5 (0.59) KDM4EALDH1A1ALOX5MPI
SCHEMBL194708 0.78 KDM4E (0.44) KDM4ETP53TSHRGAAMAPK1
SCHEMBL19577293 0.76 KDM4E (0.61) KDM4ETP53TSHRGAAMAPK1
SCHEMBL7070837 0.75 KDM4E (0.42) KDM4ETP53TSHRGAAMEN1
SCHEMBL1618278 0.74 KDM4E (0.59) KDM4ETP53TSHRGAAMAPK1
SCHEMBL31091767 0.74 KDM4E (1.00) KDM4ETP53TSHRGAAMAPK1
SCHEMBL1101962 0.74 KDM4E (1.00) KDM4ETP53TSHRGAAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 245 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112689758-B Device and method for checking the effect of a drug on microorganisms 上海宜晟生物科技有限公司 2025-03-28 CN claimed
EP-4509172-A2 ORAL AMINODIHYDROPHTHALAZINEDIONE COMPOSITIONS AND THEIR USE THE TREATMENT OF NON-VIRAL HEPATITIS IMMUNOPHARMA PLUS D.O.O. (SI) 2025-02-19 EP claimed
EP-3870175-B1 ORAL AMINODIHYDROPHTHALAZINEDIONE COMPOSITIONS AND THEIR USE THE TREATMENT OF NON-VIRAL HEPATITIS IMMUNOPHARMA PLUS D O O (SI) 2024-08-28 EP claimed
CN-117589752-A System and method for simultaneously realizing in-situ detection of Fe (II) and Mn (II) in seawater 同济大学 2024-02-23 CN claimed
US-20240033349-A1 VACCINE AND METHOD OF PROTECTION AGAINST CORONAVIRUS INFECTION ABIDOV MUSA TAZHUDINOVICH (RU) 2024-02-01 US claimed
CN-113929748-B Kit for detecting BACE1 enzyme activity and application thereof 中国科学技术大学 2023-10-20 CN claimed
US-20210379063-A1 ORAL AMINODIHYDROPHTHALAZINEDIONE COMPOSITIONS AND THEIR USE IN THE TREATMENT OF NON-VIRAL HEPATITIS IMMUNOPHARMA PLUS D.O.O. (SI) 2021-12-09 US claimed
US-20200140450-A1 CHEMICAL METHOD OF PRODUCING SMTP GROUPS OR SMTP-7 AND INTERMEDIATES USED IN THE METHOD SHOWA UNIVERSITY (JP) 2020-05-07 US claimed
EP-2508611-B1 Process for production of triprenyl phenol compounds TMS CO LTD (JP) 2019-05-08 EP claimed
EP-3397257-A1 COMPOSITIONS AND NETHODS FOR TREATING BRAIN DYSFUNCTION Bach Pharma, Inc. (US) 2018-11-07 EP claimed
EP-2508611-A1 Process for production of triprenyl phenol compounds Tokyo University of Agriculture and Technology TLO Co., Ltd. (JP) 2012-10-10 EP claimed
US-20120100579-A1 TRIPRENYL PHENOL COMPOUND, PROCESS FOR PRODUCTION OF TRIPRENYL PHENOL COMPOUND, AND THROMBOLYSIS ENHANCER TOKYO UNIVERSITY OF AGRICLATURE AND TECHNOLOGY TLO CO., LTD. (JP) 2012-04-26 US claimed
US-20110275642-A1 NEW METHOD FOR OBTAINING 5-AMINO 2,3-DIHYDROPHTHALAZINE-1,4-DIONE ALKALI METAL SALTS AND THEIR USE IN MEDICINE Abidopharma PL SP. Z.O.O. (PL) 2011-11-10 US claimed
US-8048642-B2 Heme choline esters and uses thereof GENERAL ELECTRIC COMPANY (US) 2011-11-01 US claimed
US-20090216028-A1 Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY TLO CO., LTD. (JP) 2009-08-27 US claimed
US-20090155829-A1 HEME CHOLINE ESTERS AND USES THEREOF GENERAL ELECTRIC COMPANY (US) 2009-06-18 US claimed
EP-2000540-A9 TRIPRENYL PHENOL COMPOUND, PROCESS FOR PRODUCTION OF TRIPRENYL PHENOL COMPOUND, AND THROMBOLYSIS ENHANCER Tokyo University of Agriculture and Technology TLO Co., Ltd. (JP) 2009-03-25 EP claimed
EP-2000540-A2 TRIPRENYL PHENOL COMPOUND, PROCESS FOR PRODUCTION OF TRIPRENYL PHENOL COMPOUND, AND THROMBOLYSIS ENHANCER Tokyo University of Agriculture and Technology TLO Co., Ltd. (JP) 2008-12-10 EP claimed
US-20050080260-A1 Preparation of prodrugs for selective drug delivery LUMINIDE 2005-04-14 US claimed
EP-0414730-B1 Chemical Compounds and pharmaceutical compositions capable of releasing a drug MILLS RANDELL L (US) 1999-12-15 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050080260-A1 Preparation of prodrugs for selective drug delivery APEH, PAH, ALAD KDM4E 3072/4885TP53 2677/4885TSHR 3654/4885
US-20110275642-A1 NEW METHOD FOR OBTAINING 5-AMINO 2,3-DIHYDROPHTHALAZINE-1,4-DIONE ALKALI METAL SALTS AND THEIR USE IN MEDICINE ADH1C, SCN5A, ADH1A KDM4E 2263/4885TP53 2286/4885TSHR 3071/4885
US-20200140450-A1 CHEMICAL METHOD OF PRODUCING SMTP GROUPS OR SMTP-7 AND INTERMEDIATES USED IN THE METHOD TST, SMS, TMSB4X KDM4E 2155/4885TP53 3584/4885TSHR 957/4885
US-20090155829-A1 HEME CHOLINE ESTERS AND USES THEREOF BCHE, ACHE, CHKB KDM4E 613/4885TP53 4303/4885TSHR 2878/4885
US-20090216028-A1 Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer PLAT, F2R, F12 KDM4E 2025/4885TP53 4117/4885TSHR 225/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.