SCHEMBL1932047

SCHEMBL1932047

CC(C)(Cc1ccncc1)NC(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.49
ALDH1A1 P00352 2/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
GAA P10253 2/20 0.44
FDPS P14324 1/20 0.43
TSHR P16473 2/20 0.40
LMNA P02545 1/20 0.40
CYP2D6 P10635 1/20 0.40
OPRM1 P35372 1/20 0.40
OPRD1 P41143 1/20 0.40
OPRK1 P41145 1/20 0.40
PTPRB P23467 1/20 0.40
NPC1 O15118 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MAPK1 P28482 1/20 0.40
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6501640 0.86 ACACB (0.49) RAB9AALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL5948337 0.83 CYP3A4 (0.67) RAB9AALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL25343200 0.83 ALDH1A1 (0.41) RAB9AALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL3242672 0.81 RAB9A (0.45) RAB9AALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL27561204 0.81 RAB9A (0.49) RAB9AALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL19808628 0.81 HPGD (0.51) RAB9AALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL4066043 0.80 NAPRT (0.51) ALDH1A1CYP3A4CYP2C9CYP2C19FDPS
SCHEMBL27540464 0.80 CYP17A1 (0.53) RAB9AALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL27461036 0.80 CYP3A4 (0.50) ALDH1A1CYP3A4CYP2C9CYP2C19FDPS
SCHEMBL4171208 0.80 ESR1 (0.59) ALDH1A1CYP3A4CYP2C9CYP2C19TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230058178-A1 METHODS AND MATERIALS FOR TREATING NERVE INJURY AND/OR PROMOTING WOUND HEALING UNITED STATES GOVERNMENT 2023-02-23 US claimed
WO-2021150773-A1 METHODS AND MATERIALS FOR TREATING NERVE INJURY AND/OR PROMOTING WOUND HEALING THE PENN STATE RESEARCH FOUNDATION (US) 2021-07-29 WO claimed
CN-101723911-B Method for synthesizing N-aryl-1,3-oxazolin-2-one compounds UNIV XUZHOU NORMAL 2012-07-04 CN claimed
CN-101723911-A Method for synthesizing N-aryl-1,3-oxazolin-2-one compounds UNIV XUZHOU NORMAL 2010-06-09 CN claimed
EP-1567497-B1 PYRIDINES FOR TREATING INJURED MAMMALIAN NERVE TISSUE PURDUE RESEARCH FOUNDATION (US) 2009-09-23 EP claimed
US-20080039490-A1 PYRIDINES FOR TREATING INJURED MAMMALIAN NERVE TISSUE PURDUE RESEARCH FOUNDATION (US) 2008-02-14 US claimed
WO-2024151969-A1 POTASSIUM CHANNEL BLOCKERS OR DERIVATIVES THEREOF FOR PREVENTING, ALLEVIATING, AND/OR TREATING MORBIDITY AND MORTALITY INDUCED BY PATHOGENS OR OTHER INDUCERS OF IMMUNE EXHAUSTION AND/OR EXCESS IMMUNE ACTIVATION UNIVERSITY OF ROCHESTER (US) 2024-07-18 WO disclosed
US-20240058312-A1 METHODS AND MATERIALS FOR TREATING BONE LOSS THE PENN STATE RESEARCH FOUNDATION 2024-02-22 US disclosed
US-20240024216-A1 METHODS AND MATERIALS FOR TREATING HAIR LOSS THE PENN STATE RESEARCH FOUNDATION 2024-01-25 US disclosed
WO-2024011220-A1 POTASSIUM CHANNEL BLOCKERS OR DERIVATIVES THEREOF FOR PREVENTING, ALLEVIATING, AND/OR TREATING TISSUE DYSFUNCTION CAUSED BY TOXIC INSULTS UNIVERSITY OF ROCHESTER (US) 2024-01-11 WO disclosed
EP-4274551-A1 METHODS AND MATERIALS FOR TREATING BONE LOSS THE PENN STATE RESEARCH FOUNDATION (US) 2023-11-15 EP disclosed
EP-4274546-A1 METHODS AND MATERIALS FOR TREATING HAIR LOSS THE PENN STATE RESEARCH FOUNDATION (US) 2023-11-15 EP disclosed
US-20230346758-A1 4-AMINOPYRIDINE (4-AP) AND BONE MORPHOGENETIC PROTEIN 2 (BMP-2) THE PENN STATE RESEARCH FOUNDATION 2023-11-02 US disclosed
US-20110130429-A1 PYRIDINES FOR TREATING INJURED MAMMALIAN NERVE TISSUE PURDUE RESEARCH FOUNDATION (US) 2011-06-02 US disclosed
EP-1751155-B1 SUBSTITUTED AZACHINAZOLINES HAVING AN ANTIVIRAL ACTION BAYER HEALTHCARE AG (DE) 2009-01-07 EP disclosed
WO-2007061554-A2 DOSAGE OF 4-AMINOPYRIDINE DERIVATIVES FOR TREATMENT OF CENTRAL NERVOUS SYSTEM INJURIES PURDUE RESEARCH FOUNDATION (US) 2007-05-31 WO disclosed
EP-1751155-A1 SUBSTITUTED AZACHINAZOLINES HAVING AN ANTIVIRAL ACTION Bayer HealthCare AG (DE) 2007-02-14 EP disclosed
WO-2005113552-A1 SUBSTITUTED AZACHINAZOLINES HAVING AN ANTIVIRAL ACTION BAYER HEALTHCARE AG (DE) 2005-12-01 WO disclosed
US-20020052513-A1 Oxamide IMPDH inhibitors HOFFMANN-LA ROCHE INC. 2002-05-02 US disclosed
EP-1127883-A2 Oxamides as IMPDH inhibitors F. HOFFMANN-LA ROCHE AG (CH) 2001-08-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230346758-A1 4-AMINOPYRIDINE (4-AP) AND BONE MORPHOGENETIC PROTEIN 2 (BMP-2) BMP4, BMP2, BMP1 RAB9A 1170/4885ALDH1A1 4063/4885CYP3A4 3665/4885
US-20020052513-A1 Oxamide IMPDH inhibitors IMPDH1, IMPDH2, IMPA1 RAB9A 3252/4885ALDH1A1 33/4885CYP3A4 582/4885
US-20240058312-A1 METHODS AND MATERIALS FOR TREATING BONE LOSS BMP4, ACP3, COL2A1 RAB9A 2023/4885ALDH1A1 2236/4885CYP3A4 4340/4885
US-20080039490-A1 PYRIDINES FOR TREATING INJURED MAMMALIAN NERVE TISSUE P2RY4, INA, PMP22 RAB9A 3684/4885ALDH1A1 298/4885CYP3A4 2178/4885
US-20240024216-A1 METHODS AND MATERIALS FOR TREATING HAIR LOSS BMP4, S100A4, S100B RAB9A 3706/4885ALDH1A1 203/4885CYP3A4 3723/4885
US-20110130429-A1 PYRIDINES FOR TREATING INJURED MAMMALIAN NERVE TISSUE PMP22, SMN1; SMN2, MUSK RAB9A 2051/4885ALDH1A1 256/4885CYP3A4 3082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.