Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | KHK | P50053 | 3/20 | 0.31 |
| ▸ | HTR6 | P50406 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27228493 | 0.84 | MAPT (0.34) | LMNASMN1; SMN2ALDH1A1RXFP1L3MBTL1 | |
| SCHEMBL4033910 | 0.66 | GAA (0.36) | LMNASMN1; SMN2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27228405 | 0.64 | HTR1A (0.41) | LMNASMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL4333871 | 0.59 | POLB (0.60) | LMNAALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL25296196 | 0.57 | LMNA (0.34) | LMNA | |
| SCHEMBL2183784 | 0.56 | RECQL (0.61) | LMNASMN1; SMN2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL25045802 | 0.56 | DRD2 (0.40) | CYP1A2 | |
| SCHEMBL22979601 | 0.55 | LMNA (0.43) | LMNASMN1; SMN2ALDH1A1TSHRCYP1A2 | |
| SCHEMBL26121151 | 0.55 | CA1 (0.48) | LMNASMN1; SMN2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL5361399 | 0.55 | CA12 (0.47) | SMN1; SMN2TSHRHSD17B10KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389618-B1 | PYRAZOLO 1,5-A PYRIDINES AND MEDICINES CONTAINING THE SAME | EISAI R&D MAN CO LTD (JP) | 2011-06-15 | — | — | EP | disclosed |
| US-7625925-B2 | Pyrazolo[1,5-a]pyridines and medicines containing the same | EISAI R&D MANAGEMENT CO., LTD (JP) | 2009-12-01 | — | — | US | disclosed |
| EP-1555265-B1 | 7-PHENYL PYRAZOLOPYRIDINE COMPOUNDS | EISAI R&D MAN CO LTD (JP) | 2009-03-25 | — | — | EP | disclosed |
| US-20080076943-A1 | 7-PHENYLPYRAZOLOPYRIDINE COMPOUNDS | HIBI SHIGEKI | 2008-03-27 | — | — | US | disclosed |
| US-7323569-B2 | 7-phenylpyrazolopyridine compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-01-29 | — | — | US | disclosed |
| US-20070249663-A1 | PYRAZOLO[1,5-a]PYRIDINES AND MEDICINES CONTAINING THE SAME | HIBI SHIGEKI | 2007-10-25 | — | — | US | disclosed |
| US-7285666-B2 | Pyrazolo[1,5-a] pyridines and medicines containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-10-23 | — | — | US | disclosed |
| US-7176216-B2 | 7-phenylpyrazolopyridine compounds | EISAI CO., LTD. (JP) | 2007-02-13 | — | — | US | disclosed |
| US-20060235011-A1 | 7-Phenyl pyrazolopyridine compounds | EISAI CO.LTD. (JP) | 2006-10-19 | — | — | US | disclosed |
| US-20060217348-A1 | Pyrazolo[1,5-a] pyridines and medicines containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-09-28 | — | — | US | disclosed |
| US-7091215-B2 | Pyrazolo[1,5-a]pyridines and medicines containing the same | EISAI CO., LTD. (JP) | 2006-08-15 | — | — | US | disclosed |
| EP-1555265-A1 | 7-PHENYL PYRAZOLOPYRIDINE COMPOUNDS | Eisai Co., Ltd. (JP) | 2005-07-20 | — | — | EP | disclosed |
| US-20040224974-A1 | 7-phenylpyrazolopyridine compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-11-11 | — | — | US | disclosed |
| US-20040122039-A1 | Pyrazolo[1,5-a]pyridines and medicines containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-06-24 | — | — | US | disclosed |
| EP-1389618-A1 | PYRAZOLO 1,5-A]PYRIDINES AND MEDICINES CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2004-02-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249663-A1 | PYRAZOLO[1,5-a]PYRIDINES AND MEDICINES CONTAINING THE SAME | NR3C1, NR3C2, NR5A2 | LMNA 2983/4885SMN1; SMN2 3648/4885ALDH1A1 2022/4885 |
| US-20040224974-A1 | 7-phenylpyrazolopyridine compounds | CRHR1, MC2R, CRH | LMNA 4734/4885SMN1; SMN2 4074/4885ALDH1A1 2616/4885 |
| US-20080076943-A1 | 7-PHENYLPYRAZOLOPYRIDINE COMPOUNDS | MC2R, CRHR1, CRHR2 | LMNA 4727/4885SMN1; SMN2 3905/4885ALDH1A1 3348/4885 |
| US-20040122039-A1 | Pyrazolo[1,5-a]pyridines and medicines containing the same | XDH, NR3C1, NR5A1 | LMNA 2972/4885SMN1; SMN2 3499/4885ALDH1A1 1142/4885 |
| US-20060235011-A1 | 7-Phenyl pyrazolopyridine compounds | MC2R, CRHR1, CRHR2 | LMNA 4718/4885SMN1; SMN2 4045/4885ALDH1A1 3334/4885 |
| US-20060217348-A1 | Pyrazolo[1,5-a] pyridines and medicines containing the same | NR3C1, NR3C2, NR5A2 | LMNA 2983/4885SMN1; SMN2 3648/4885ALDH1A1 2022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.