Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 15/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670428 | 0.90 | ABL1 (0.40) | GSK3BMAPK14SLC5A1IRAK4PIM1 | |
| SCHEMBL19670257 | 0.89 | HPGDS (0.38) | GSK3BMAPK14SLC5A1IRAK4PIM1 | |
| SCHEMBL19670385 | 0.89 | MPL (0.44) | GSK3BMAPK14SLC5A1IRAK4PIM1 | |
| SCHEMBL19670589 | 0.85 | HTR2C (0.42) | — | |
| SCHEMBL19670590 | 0.83 | IRAK4 (0.41) | SLC5A1KDRIRAK4PIM1 | |
| SCHEMBL19670238 | 0.83 | TRPA1 (0.38) | BRAFKDRIRAK4PIM1 | |
| SCHEMBL19669044 | 0.82 | GSK3B (0.42) | GSK3BMAPK14SLC5A1BRAFKDR | |
| SCHEMBL19670150 | 0.81 | IRAK4 (0.40) | GSK3BMAPK14SLC5A1IRAK4PIM1 | |
| SCHEMBL19670386 | 0.81 | CACNA1H (0.37) | BRAFKDRIRAK4 | |
| SCHEMBL19670362 | 0.80 | IRAK4 (0.39) | SLC5A1IRAK4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |