Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | FAP | Q12884 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856929 | 0.90 | CCR2 (0.35) | CCR2 | |
| SCHEMBL19856905 | 0.89 | BTK (0.38) | BTKCYP2C8KCNH2MCL1PLA2G10 | |
| SCHEMBL19856992 | 0.88 | CCR2 (0.34) | GAACCR2PLA2G10MGLL | |
| SCHEMBL19856935 | 0.87 | PARP10 (0.40) | BTKCYP2C8KCNH2PLA2G10PARP14 | |
| SCHEMBL19857030 | 0.86 | PLA2G10 (0.38) | CCR2PLA2G10 | |
| SCHEMBL19856941 | 0.85 | TNF (0.37) | CCR2FAAH | |
| SCHEMBL19856933 | 0.84 | HPGD (0.36) | CCR2 | |
| SCHEMBL19856957 | 0.83 | AVPR1A (0.34) | CCR2DPP4DPP7 | |
| SCHEMBL19856960 | 0.83 | PLA2G10 (0.38) | KCNH2CCR2MCL1PLA2G10 | |
| SCHEMBL19856981 | 0.81 | SIRT3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |